Time-Prolonged Release of Tumor-Targeted Protein–MMAE Nanoconjugates from Implantable Hybrid Materials

The sustained release of small, tumor-targeted cytotoxic drugs is an unmet need in cancer therapies, which usually rely on punctual administration regimens of non-targeted drugs. Here, we have developed a novel concept of protein–drug nanoconjugates, which are packaged as slow-releasing chemically hybrid depots and sustain a prolonged secretion of the therapeutic agent. For this, we covalently attached hydrophobic molecules (including the antitumoral drug Monomethyl Auristatin E) to a protein targeting a tumoral cell surface marker abundant in several human neoplasias, namely the cytokine receptor CXCR4. By this, a controlled aggregation of the complex is achieved, resulting in mechanically stable protein–drug microparticles. These materials, which are mimetics of bacterial inclusion bodies and of mammalian secretory granules, allow the slow leakage of fully functional conjugates at the nanoscale, both in vitro and in vivo. Upon subcutaneous administration in a mouse model of human CXCR4+ lymphoma, the protein–drug depots release nanoconjugates for at least 10 days, which accumulate in the tumor with a potent antitumoral effect. The modification of scaffold cell-targeted proteins by hydrophobic drug conjugation is then shown as a novel transversal platform for the design of slow releasing protein–drug depots, with potential application in a broad spectrum of clinical settings.

The relevance of false-twist addition on ring spun yarns by means of rotary threaded surfaces

A novel concept of producing false-twist yarns by cyclical stress fluctuation was developed. The forming principle was introduced to analyze the formation process of false twists on rotary threaded contact surfaces. Geometric analysis indicates that cyclical stress variations produce extra rotations (false twists) on fiber strands in the yarn formation area, causing twist redistribution and fiber arrangement remodeling with the appearance of local fiber reversion. Theoretical analysis reveals that more false twists are produced when the spun yarn is in contact with surfaces of high traverse speeds. Then, a motion simulation model using different traverse speeds of the threaded contact surface was established to compare the yarn internal stress variation, verifying the false-twist efficiency at different traverse speeds. Finally, a systematic comparison was conducted between the yarns spun at different traverse speeds. It was shown that the yarn properties improved with higher traverse speeds of the threaded contact surface, achieving less hairiness, high yarn strength, and low residual torque.

Computational Investigation of a Novel Box-Wing Aircraft Concept

With regard to the current needs for greener aviation, this study focuses on a novel concept of Box-Wing Aircraft (BWA). Labelled SmartLiner (BWA/SL), this conceptual aircraft comes as a triplane comprising backward and forward swept wings. The aerodynamic performance and structural characteristics of this BWA/SL aircraft are here explored through numerical simulation, using Computational Fluid Dynamics (CFD) and Fluid-Structure Interaction (FSI). The computational approach is first validated using NASA’s Common Research Model (CRM) aircraft, which is then taken as a reference solution against which to compare the aero-structural merits of the BWA/SL concept. Results show that, although its design is still preliminary and lacks optimization, the BWA/SL aircraft exhibits very decent aerodynamic performance, with higher lifting capacities and a reasonable lift-to-drag ratio. Moreover, thanks to the closed frame of its peculiar planform, it demonstrates superior structural characteristics, including under extreme loading scenarios. Based on this preliminary analysis and considering the room left for its further optimization, this conceptual aircraft thus appears as a potentially promising alternative for the development of more environmentally friendly airliners.

Design of an Innovative Test Rig for Industrial Bearing Monitoring with Self-Balancing Layout

The remote prognosis and diagnosis of bearings can prevent industrial system failures, but the availability of realistic experimental data, being as close as possible to those detected in industrial applications, is essential to validate the monitoring algorithms. In this paper, an innovative bearing test rig architecture is presented, based on the novel concept of “self-contained box”. The monitoring activity is applicable to a set of four middle-sized bearings simultaneously, while undergoing the independent application of radial and axial loads in order to simulate the behavior of the real industrial machinery. The impact of actions on the platform and supports is mitigated by the so-called “self-contained box” layout, leading to self-balancing of actions within the rotor system. Moreover, the high modularity of this innovative layout allows installing various sized bearings, just changing mechanical adapters. This leads to a reduction of cost as well as of system down-time required to change bearings. The test rig is equipped with suitable instrumentation to develop effective procedures and tools for in- and out-monitoring of the system. An initial characterization of the healthy system is presented.

Decision-Making Approach Based on Generalized Aggregation Operators with Complex Single-Valued Neutrosophic Hesitant Fuzzy Set Information

A strategic decision-making technique can help the decision maker to accomplish and analyze the information in an efficient manner. However, in our real life, an uncertainty will play a dominant role during the information collection phase. To handle such uncertainties in the data, we present a decision-making algorithm under the single-valued neutrosophic (SVN) environment. The SVN is a powerful way to deal the information in terms of three degrees, namely, “truth,” “falsity,” and “indeterminacy,” which all are considered independent. The main objective of this study is divided into three folds. In the first fold, we state the novel concept of complex SVN hesitant fuzzy (CSVNHF) set by incorporating the features of the SVN, complex numbers, and the hesitant element. The various fundamental and algebraic laws of the proposed CSVNHF set are described in details. The second fold is to state the various aggregation operators to obtain the aggregated values of the considered CSVNHF information. For this, we stated several generalized averaging operators, namely, CSVNHF generalized weighted averaging, ordered weighted average, and hybrid average. The various properties of these operators are also stated. Finally, we discuss a multiattribute decision-making (MADM) algorithm based on the proposed operators to address the problems under the CSVNHF environment. A numerical example is given to illustrate the work and compare the results with the existing studies’ results. Also, the sensitivity analysis and advantages of the stated algorithm are given in the work to verify and strengthen the study.

Real & Simulated QPSK Up-Converted Signals by a Sampling Method Using a Cascaded MZMs Link

This study focuses on a novel concept of transmitting of a quadrature phase shift keying (QPSK) modulation by an electro-optical frequency up-conversion using a cascaded Mach–Zehnder modulators (MZMs) link. Furthermore, we conduct and compare the results obtained by simulations using the Virtual Photonics Inc. (VPI) (Berlin, Germany) simulator and real-world experiments. The design and operating regime peculiarities of the MZM used as a sampling up-converter mixer in a radio over fiber (RoF) system are also analyzed. Besides, the simulation and experimental results of static and dynamic characteristics of the MZM have approximately the same behavior. The conversion gain of the cascaded MZMs link is simulated over many mixing frequencies and it can decrease from 17.5 dB at 8.3 GHz to −4.5 dB at 39.5 GHz. However, in real world settings, it may decrease from 15.5 dB at 8.3 GHz to −6 dB at 39.5 GHz. The maximum frequency range is attained at 78.5 GHz for up-conversion through simulations. Error vector magnitude (EVM) values have been done to evaluate the performance of our system. An EVM of 16% at a mixing frequency of 39.5 GHz with a bit rate of 12.5 Gbit/s was observed with the considering sampling technique, while it reached 19% in real-world settings with a sampling frequency of 39.5 GHz and a bit rate of 12.5 Gbit/s.

Assessment of Functional Food Dioscorea Japonica Paste As A Thickened Liquid For Elderly With Dysphagia

Background: In the elderly, reduced mastication and swallowing functions result in malnutrition and deterioration in the quality of life. As individuals age in the society, the novel concept of dysphagia diet is essential in order to prevent lifestyle and chronic diseases and maintain nutrition intake. Recently, we reported that Dioscorea japonica, a wild yam, has preventive effects on chronic inflammation via the inhibition of proinflammatory lipid mediator synthesis. The paste of Dioscorea japonica showed conformable physical properties as a thickened liquid for patients with dysphagia in rheological analysis. In the present study, we focused on the unique physical properties of Dioscorea japonica paste and evaluated its stability and usefulness as a thickened liquid compared with commercially available thickened liquids. Methods: The paste prepared using a uniformly freeze-dried Dioscorea japonica powder could suitably modify the viscosity by altering the blending amount. Viscosities of the Dioscorea japonica paste, xanthan gum, and commercially available thickened liquids were measured using a cone and plate viscometer after 1 min by employing the following setting: temperature of 20°C and shear rate of 50 s−1. The effect of changes in temperature and pH, and addition of NaCl and α-amylase, on viscosity was compared among the thickened liquids. Results: Compared with the other commercially available agents, the Dioscorea japonica paste was stable in terms of viscosity on the addition of NaCl, and no change was observed on the addition of α-amylase as similar as the others. Although the Dioscorea japonica paste was relatively stable in terms of viscosity with change in pH, it was slightly unstable with change in temperature. Conclusion: The findings of this study indicate that the Dioscorea japonica paste is useful as a novel type of thickened liquid for patients with dysphagia.

Improving Energy Efficiency by Utilizing Wetted Cellulose Pads in Passive Cooling Systems

The effectiveness of using wetted cellulose pads on improving the performance of two conventional passive cooling systems has been evaluated. First, an experimental design was developed to determine the impact of using a wetted cellulose pad on the temperature and velocity of the airflow. A cellulose pad (7090 model) with a cross-sectional area of 0.5 × 0.5 m2 and three different thicknesses of 10, 15, and 30 cm were selected and tested. The results indicated that using wetted cellulose pads with thicknesses ranging from 10–30 cm decreased the outlet airflow temperature from 11.3 to 13.7 °C on average. For free airflow at velocity 3.5 m/s, the outlet airflow velocity from the wetted cellulose pad decreased to 0.9, 0.7 and 0.6 m/s, respectively, for cellulose pads with thicknesses of 10, 15, and 30 cm. By applying experimental results on a psychrometric chart, the humidity ratio of outlet airflow was obtained between 40–70%. The study established airflow velocity as the critical parameter in passive cooling systems. With the novel concept of combining wetted cellulose pads for passive cooling systems (i.e., wind catchers and induced ventilation), there is good potential to reduce the energy requirements for thermal comfort in buildings in regions with a hot and arid climate.