mediastinal paraganglioma
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2022 ◽  
Vol 12 ◽  
Author(s):  
Bo Li ◽  
Zhe Yan ◽  
Hui Huang

Ectopic adrenocorticotrophic hormone (ACTH) syndrome is not common, which is more unusual when caused by paraganglioma. We herein present a 40-year-old Chinese male who was diagnosed with ACTH-dependent Cushing’s syndrome. However, the localization of the ACTH source was troublesome due to the inconsistent results of the high-dose dexamethasone suppression test and the desmopressin stimulation test. Bilateral inferior petrosal sinus sampling was performed, and ectopic ACTH syndrome was diagnosed. After 68Ga-DOTATATE-PET/CT and 18F-FDG-PET/CT were performed, it was localized in the anterior mediastinum. Post-operation histopathology demonstrated an ACTH-secreting mediastinal paraganglioma. The patient obtained complete clinical remission after a mediastinal tumorectomy.


2021 ◽  
Vol 86 ◽  
pp. 106357
Author(s):  
Daniel Bianchi ◽  
Adriana Scamporlino ◽  
Matteo Costantini ◽  
Giorgio Cavallesco ◽  
Uliano Morandi ◽  
...  

Author(s):  
Mark Quinn ◽  
Carroll Paul ◽  
Barbara McGowan ◽  
Mamta Joshi ◽  
Louise Izatt ◽  
...  

2020 ◽  
Author(s):  
Ryosuke Takahashi ◽  
Hiroaki Kawabe ◽  
Nobuaki Koide ◽  
Akihisa Tasaki ◽  
Kazuchika Ohno ◽  
...  

2020 ◽  
Vol 15 (9) ◽  
pp. 1528-1531
Author(s):  
Ryan Bailey ◽  
Akash Sharma ◽  
Ephraim E. Parent

2020 ◽  
Vol 35 (8) ◽  
pp. 2047-2049
Author(s):  
Dao M. Nguyen ◽  
Jessica N. Gonzalez ◽  
Nestor R. Villamizar

2020 ◽  
Vol 4 (3) ◽  
pp. 1-6 ◽  
Author(s):  
Maria Trêpa ◽  
Inês Silveira ◽  
Cláudia Amaral ◽  
André Luz

Abstract Background Mediastinal paragangliomas (PGs) are rare and particularly challenging neuroendocrine tumours. Clinical presentation is heterogeneous and tumour resection can be challenging due to bleeding and the risk of catecholamine surges in functional tumours. Case Summary A 36-year-old man with multiple cardiovascular risk factors was admitted with subacute heart failure. Investigations revealed a large non-metastatic functional mediastinal PG irrigated mainly by a left circumflex coronary anomalous feeder branch. The surgical risk was deemed very high due to patient comorbidities, tumour vascularization, and close relation to major thoracic structures. A multidisciplinary team decided to perform embolization of the anomalous coronary branch followed by peptide-receptor radionuclide therapy with 177-LuDOTATE aiming to decrease tumour size and perioperative risk. Follow-up studies showed a reduction in tumour vascularization, size, and hormonal production. Discussion The innovative strategy of combining embolization of the anomalous feeder branch with radionuclide therapy proved to be a promising approach.


2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Basil Alomair ◽  
Anwar Jammah

Abstract Paraganglioma is a rare type of neuroendocrine tumor of the autonomicnervous system.1 It is extremely rarely present in mediastinum (less than2%).2Case report We report a 43 years-old woman, she was referred to our clinic with ahistory of high blood pressure (BP) for two years, accompanied by spellsof sweating, headache, anxiety and palpitation. She was provisionaldiagnosed with essential hypertension and was on four medications onmaximum dose.The patient declined any previous surgical history, and review of systemswas unremarkable. On examination, she was conscious and alert. Her vitalsigns were within normal limit. She reported to our clinic with homereadings of BP ranging from 150-180 mmHg systolic and 90-100 mmHgdiastolic.Initial investigations of basic chemistry, renal profile, hormonal profile,aldosterone, and renin were within the normal range.Serum Normetanephrine was 800 ng/L (normal < 180 ng/L), 24 hoursurine of Normetanephrine was 5205 microgram/24 hours (normal < 600microgram/24 hours), and 24 hours urine Metanephrine was withinnormal. CT scan of the adrenal and MRI abdomen showed normal adrenalglands and no mass in the abdomen. MIBG scan was normal for the wholebody. An unusual location of the Paraganglioma was suspected, andfurther images were carried on. A CT chest showed 4x4 cm posteriormediastinal mass in area of Aortopulmonary window, adherent toposterior wall of Aorta and pulmonary artery. Positron EmissionTomography (PET) scan was done prior to the surgery.Surgical resection of the mass with reconstruction of both pulmonaryartery and pericardium was done without any complications. Moreover,histopathology confirmed the diagnosis of Paraganglioma.The patient was followed up with a CT scan six months post-operativelyas an outpatient, along with 24-hour urine Metanephrine and Normetanephrine. All labs and imaging were normal. The patient hadanother Normetanephrine measurement twelve months later and it wasnormal. Now, she has been followed for seven years with no moresymptoms and normal BP readings. All of her antihypertensive agentswere discontinued. ConclusionWe experience an unusual location of Paraganglioma at the mediastinum,which is representing less than 2% of all Paraganglioma. However, in thepresence of characteristic of Paraganglioma symptoms, a thoroughassessment should be carried out and such location of mediastinumshould be suspected and investigated.References:1. Institute NC. Pheochromocytoma and Paraganglioma Treatment(PDQ®)-Health Professional Version. https://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq. Published 2019. Accessed February 1, 2020.2. Paraganglioma: An Uncommon Cause of Mediastinal Mass. -PubMed - NCBI. https://www.ncbi.nlm.nih.gov/pubmed/32000513.Accessed February 1, 2020.


BMC Surgery ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hiroaki Shidei ◽  
Hideyuki Maeda ◽  
Tamami Isaka ◽  
Takako Matsumoto ◽  
Tomoko Yamamoto ◽  
...  

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