large population sample
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2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Arthur Gustavo Fernandes ◽  
Monica Alves ◽  
Roberta Andrade e Nascimento ◽  
Natalia Yumi Valdrighi ◽  
Rafael Cunha de Almeida ◽  
...  

Abstract Background Most estimates of visual impairment and blindness worldwide do not include data from specific minority groups as indigenous populations. We aimed to evaluate frequencies and causes of visual impairment and blindness in a large population sample from the Xingu Indigenous Park. Methods Cross-sectional study performed at Xingu Indigenous Park, Brazil, from 2016 to 2017. Residents from 16 selected villages were invited to participate and underwent a detailed ocular examination, including uncorrected (UVA) and best-corrected visual acuity (BCVA). The main cause of UVA < 20/32 per eye was determined. Results A total of 2,099 individuals were evaluated. Overall, the frequency of visual impairment and blindness was 10.00% (95% CI: 8.72–11.29%) when considering UVA, decreasing to 7.15% (95% CI: 6.04–8.25%) when considering BCVA. For each increasing year on age, the risk  of being in the visually impaired or blind category increased by 9% (p < 0.001). Cataracts (39.1%) and uncorrected refractive errors (29.1%) were the most frequent causes of visual impairment and blindness in this population. The main causes among those aged 45 years and more were cataracts (54.5%) while refractive errors were the main cause in adults aged 18 to 45 years (50.0%) and children up to 18 years old (37.1%). Conclusions A higher frequency of visual impairment and blindness was observed in the indigenous population when compared to worldwide estimates with most of the causes being preventable and/or treatable. Blindness prevention programs should focus on accessibility to eye exam, cataract surgeries and eyeglass distribution.


2021 ◽  
Author(s):  
Mads Kock Pedersen ◽  
Carlos Mauricio Castaño Díaz ◽  
Mario Alejandro Alba-Marrugo ◽  
Ali Amidi ◽  
Rajiv Vaid Basaiwmoit ◽  
...  

Psychology and the social sciences are undergoing a revolution: It has become increasingly clear that traditional lab-based experiments fail to capture the full range of differences in cognitive abilities and behaviours across the general population. Some progress has been made toward devising measures that can be applied at scale across individuals and populations. What has been missing is a broad battery of validated tasks that can be easily deployed, used across different age ranges and social backgrounds, and employed in practical, clinical, and research contexts. Here, we present Skill Lab, a game-based approach allowing the efficient assessment of a suite of cognitive abilities. Skill Lab has been validated outside the lab in a crowdsourced population-size sample recruited in collaboration with the Danish Broadcast Company (Danmarks Radio, DR). Our game-based measures are five times faster to complete than the equivalent traditional measures and replicate previous findings on the decline of cognitive abilities with age in a large population sample. Furthermore, by combining the game data with an in-game survey, we demonstrate that this unique dataset has implication for key questions in social science, challenging the Jack-of-all-Trades theory of entrepreneurship and provide evidence for risk preference being independent of executive functioning.


Gut Microbes ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1-22
Author(s):  
Matti O. Ruuskanen ◽  
Fredrik Åberg ◽  
Ville Männistö ◽  
Aki S. Havulinna ◽  
Guillaume Méric ◽  
...  

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241373 ◽  
Author(s):  
Lars B. Hindenes ◽  
Asta K. Håberg ◽  
Liv Hege Johnsen ◽  
Ellisiv B. Mathiesen ◽  
David Robben ◽  
...  

2020 ◽  
Author(s):  
Lars B. Hindenes ◽  
Asta K. Håberg ◽  
Liv Hege Johnsen ◽  
Ellisiv B. Mathiesen ◽  
David Robben ◽  
...  

AbstractThe main arteries that supply blood to the brain originate from the Circle of Willis (CoW). The CoW exhibit considerable anatomical variations which may have clinical importance, but the variability is insufficiently characterised in the general population. We assessed the anatomical variability of CoW variants in a community-dwelling sample (N = 1,864, 874 men, mean age = 65.4, range 40 – 87 years), and independent and conditional frequencies of the CoW’s artery segments. CoW segments were classified as present or missing/hypoplastic (w/1mm diameter threshold) on 3T time-of-flight magnetic resonance angiography images. We also examined whether age and sex were associated with CoW variants. We identified 47 unique CoW variants, of which five variants constituted 68.5% of the sample. The complete variant was found in 11.9% of the subjects, and the most common variant (27.8%) was missing both posterior communicating arteries. Conditional frequencies showed patterns of interdependence across most missing segments in the CoW. CoW variants were associated with mean-split age (P = .0147), and there was a trend showing more missing segments with increasing age. We found no association with sex (P = .0526). Our population study reinforced age as associated with CoW variants, suggesting reduced collateral supply with older age.


2020 ◽  
Author(s):  
Tobias Riehm ◽  
Nicolas Fugger ◽  
Philippe Gillen ◽  
Vitali Gretschko ◽  
Peter Werner

Author(s):  
Juan Carlos Aviles Solis ◽  
Cristina Jácome ◽  
Hans Pasterkamp ◽  
Hasse Melbye

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