<p>The Mesozoic era (~252&#8212;66 Ma) is traditionally considered as a prolonged greenhouse period, witnessing the breakup of the Pangaean supercontinent. Orbital cycles have, for example, been invoked as drivers of e.g. Pangaean &#8222;Megamonsoon&#8220; variability and eustatic sea level cycles in the Mesozoic.</p><p>We aim to contribute to a more comprehensive understanding of orbital effects on Mesozoic climates by employing the newly developed CLIMBER-X Earth System Model. Here, we primarily use its coupled atmosphere, ocean, sea ice and vegetation modules, but also include preliminary tests with dynamic carbon cycle and ice-sheets. We present first results from a set of transient climate simulations of four Mesozoic timeslices representative for Triassic, Jurassic, Early Cretaceous and Late Cretaceous boundary conditions (e.g. paleogeography and solar luminosity). The simulations each cover ~100,000 years and are driven by changing precession, obliquity, and eccentricity.</p><p>We would like to use the opportunity to discuss this approach and associated questions with the community. For example: Would changing paleogeography and climate background state have modified the response to orbital forcings? Could eustatic sea level cycles have been caused by orbitally-driven redistribution of water between the ocean and land water storages or should orbitally-forced ice sheets also have played a role in the alleged Mesozoic greenhouse? Which connections can be established to proxy records?</p>