urinary estrogens
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Author(s):  
Lusine Yaghjyan ◽  
Lancia N. F. Darville ◽  
Jayden Cline ◽  
Yessica C. Martinez ◽  
Shannan Rich ◽  
...  

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261362
Author(s):  
Nhung Le ◽  
Melissa Cregger ◽  
Veronica Brown ◽  
Julio Loret de Mola ◽  
Pamela Bremer ◽  
...  

Endometriosis is an estrogen dependent gynecological disease associated with altered microbial phenotypes. The association among endogenous estrogen, estrogen metabolites, and microbial dynamics on disease pathogenesis has not been fully investigated. Here, we identified estrogen metabolites as well as microbial phenotypes in non-diseased patients (n = 9) and those with pathologically confirmed endometriosis (P-EOSIS, n = 20), on day of surgery (DOS) and ~1–3 weeks post-surgical intervention (PSI). Then, we examined the effects of surgical intervention with or without hormonal therapy (OCPs) on estrogen and microbial profiles of both study groups. For estrogen metabolism analysis, liquid chromatography/tandem mass spectrometry was used to quantify urinary estrogens. The microbiome data assessment was performed with Next generation sequencing to V4 region of 16S rRNA. Surgical intervention and hormonal therapy altered gastrointestinal (GI), urogenital (UG) microbiomes, urinary estrogen and estrogen metabolite levels in P-EOSIS. At DOS, 17β-estradiol was enhanced in P-EOSIS treated with OCPs. At PSI, 16-keto-17β-estradiol was increased in P-EOSIS not receiving OCPs while 2-hydroxyestradiol and 2-hydroxyestrone were decreased in P-EOSIS receiving OCPs. GI bacterial α-diversity was greater for controls and P-EOSIS that did not receive OCPs. P-EOSIS not utilizing OCPs exhibited a decrease in UG bacterial α-diversity and differences in dominant taxa, while P-EOSIS utilizing OCPs had an increase in UG bacterial α-diversity. P-EOSIS had a strong positive correlation between the GI/UG bacteria species and the concentrations of urinary estrogen and its metabolites. These results indicate an association between microbial dysbiosis and altered urinary estrogens in P-EOSIS, which may impact disease progression.


2020 ◽  
Vol 1154 ◽  
pp. 122288
Author(s):  
Lancia N.F. Darville ◽  
Jayden K. Cline ◽  
Carrie Rozmeski ◽  
Yessica C. Martinez ◽  
Shannan Rich ◽  
...  

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Kirsten S. Wilson ◽  
Jella Wauters ◽  
Iain Valentine ◽  
Alan McNeilly ◽  
Simon Girling ◽  
...  

2019 ◽  
Vol 147 ◽  
pp. 157-162 ◽  
Author(s):  
Jia You ◽  
Ying Shi ◽  
Jiaqi Li ◽  
Xiaoqin Yang ◽  
Zeyu Liu ◽  
...  

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0216114 ◽  
Author(s):  
Gieira S. Jones ◽  
Heather Spencer Feigelson ◽  
Roni T. Falk ◽  
Xing Hua ◽  
Jacques Ravel ◽  
...  

2016 ◽  
Vol 7 (1) ◽  
pp. 65-74 ◽  
Author(s):  
Terryl J. Hartman ◽  
Julia S. Sisti ◽  
Susan E. Hankinson ◽  
Xia Xu ◽  
A. Heather Eliassen ◽  
...  

2015 ◽  
Vol 24 (8) ◽  
pp. 1174-1183 ◽  
Author(s):  
Julia S. Sisti ◽  
Susan E. Hankinson ◽  
Neil E. Caporaso ◽  
Fangyi Gu ◽  
Rulla M. Tamimi ◽  
...  

2014 ◽  
Vol 99 (12) ◽  
pp. 4632-4640 ◽  
Author(s):  
Barbara J. Fuhrman ◽  
Heather Spencer Feigelson ◽  
Roberto Flores ◽  
Mitchell H. Gail ◽  
Xia Xu ◽  
...  

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Ju-Yeon Moon ◽  
Eun Jig Lee ◽  
Woong Youn Chung ◽  
Myeong Hee Moon ◽  
Bong Chul Chung ◽  
...  

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