antihypertensive activity
Recently Published Documents


TOTAL DOCUMENTS

630
(FIVE YEARS 149)

H-INDEX

40
(FIVE YEARS 5)

2022 ◽  
Author(s):  
Olga S Savinova ◽  
Anna V Begunova ◽  
Oluwatosin A. Ijabadeniyi ◽  
Konstantin V. Moiseenko ◽  
Tatiana V. Fedorova

. Both Russia and South Africa have a long-standing history of fermented milk product consumption. Along with the products widely distributed around the world, such as yoghurts, in each of these countries there are a number of national products. An example of a widely demanded fermented milk product in Russia is Kefir.This productis used not only as a food source in the diet of children and adults, but also in medical institutions, since ithasa positive effect onhuman health when consumed regularly. South Africa is characterized by the consumption of products such as Amasi,which is produced commercially. Its consumption has also been shown to have beneficial effects on the digestive system. In this research, the metabolic profiles(fatty acid composition and volatile compounds) of these fermented milk products were analyzed and these showed significant differences. The results indicated that this metabolite composition reflected the different production protocols and microbial complexity of these dairy products. The functional properties of the studied drinks were also considered.The average content of L-leucine equivalents in Amasi was slightly higher (6.5-8.9mMol×L −1) than in Kefir (4.9-6.7mMol×L −1). Antioxidant and antihypertensive activity of the fermented products correlated with the depth of hydrolysis of the milk proteins. Amasishowed higher antioxidant and antihypertensive activities (600- 796µМolТE/ml and 1.3-1.5mg/ml, respectively) than Kefir (246-574µМolТE/ml and 2.0-4.3mg/ml, respectively). Keywords: fermented products, Kefir, Amasi,metabolic profile, antioxidant potential, antihypertensive properties


2021 ◽  
Vol 14 (4) ◽  
pp. 1459-1462
Author(s):  
Faiyaz Ahmed

Hypertension is a major cardiovascular problem resulting in significant mortality. Cissus quadrangularis having several pharmacological effects has not been evaluated for its ability to modulate blood pressure. Thus, the ability of C. quadrangularis aqueous extract (CQE) to modulate blood pressure was evaluated in normotensive and angiotensin II-induced hypertensive rats under urethane anesthesia. The animals were divided into four groups namely, control (saline injection), CQE (extract alone, 10 mg/kg), Ang II (Ang II alone, 0.5 µg/kg) and Ang II + CQE (Ang II + extract). All treatments were delivered by intravenous route and in Ang II + CQE group, Ang II was injected 30 min after injection of the extract. Hemodynamic parameters, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MABP), and heart rate (HR) were recorded by the BIOPAC system after the cannulation of the carotid artery and jugular vein. The results indicated that CQE lowered SBP, DBP, MABP and heart rate to varying degrees in normotensive rats compared to control groups. In case of angiotensin II-induced hypertension, CQE administration resulted in substantial decrease in SBP, DBP, and MABP which were raised by Ang II. CQE reduced SBP, DBP, and MABP by 12, 59, and 11%, respectively. It is worth noting that, while SBP was not brought down to baseline levels by CQE, DBP was, suggesting significant hypotensive/antihypertensive activity of CQE. Further research is required to determine the molecular mechanism of C. quadrangularis extract’s hypotensive/antihypertensive action and to conduct clinical trials to establish its optimal use as an antihypertensive therapeutic.


2021 ◽  
Vol 11 ◽  
Author(s):  
Abdulhalim Serafi ◽  
Aisha Azmat ◽  
Muhammad Ahmed ◽  
Mohammed Bafail ◽  
Zahir Hussain

Background: Depression is common in hypertensive patients, and monotherapy may contribute for controlling depression in hypertensive patients and improving the socioeconomic outcomes. Previous studies have shown that Acacia tortilis possesses hypotensive activity. Objectives: Hence, the present study was planned to evaluate the hemodynamic activity and antidepressant effects of an ethanolic extract of Acacia tortilis leaves (ATEL) in salt-induced hypertensive rats. Methods: Sprague-Dawley rats were divided into 5 groups for experiments. The rats received respective treatment for 15 days: G1: Control (C); G2: Hypertensive control (HC: high dietary salt, 4% 10ml/kg); G3-5: HC+ ATEL (50, 100, 150mg/kg respectively). Cardiac hemodynamics (mean arterial blood pressure: MAP and heart rate: HR) were measured in the anaesthetized rats by an invasive method. For this method, one carotid artery was catheterized, a pressure catheter (pressure volume Millar microtip catheter connected to the Mikro-Tip Pressure-Volume System from Ultra Foundation Systems, PowerLab) was inserted, and the blood pressure (MAP in mm Hg) and HR (beats/min) were monitored continuously during the experiment. For the neuropharmacological studies, antidepressant activity was assessed by forced swim test on the 15th day. Results: A dose-dependent significant increase in mobility time was observed in rats (G3-5) treated with HC + different doses of ATEL (p < 0.05). However, the mobility time was significantly reduced by HC (G2) treatment compared with that of the control (p< 0.05). The hypertensive control (high dietary salt: HC) group showed significant increases in SP, DP, MAP, and HR (p<0.05) compared to the control (G1) group. At all doses (50, 100 and 150 mg/kg), MAP and HR were found to decrease significantly (p<0.05) when compared with the values in the HC (G2) group. Further analysis revealed an improvement in heart rate variability (HRV) in ATEL-treated hypertensive rats. Conclusion: The present research suggests that increased dietary salt intake not only increases blood pressure significantly but also increases depression. ATEL contains some efficacious constituents, N, N-dimethyltryptamine (DMT: a 5-HT1A agonist) with predominant antidepressant and antihypertensive activity. Hence, ATEL appears to be a valuable plant extract that can be useful, at least as an adjunct, for therapy in patients who suffer from both depression and hypertension. Objectives: Hence, the present study was planned to evaluate the hemodynamic activity and antidepressant effects of an ethanolic extract of Acacia tortilis leaves (ATEL) in salt-induced hypertensive rats. Methods: Sprague-Dawley rats were divided into 5 groups for experiments. The rats received respective treatment for 15 days: G1: Control (C); G2: Hypertensive control (HC: high dietary salt, 4% 10ml/kg); G3-5: HC+ ATEL (50, 100, 150mg/kg respectively). Cardiac hemodynamics (mean arterial blood pressure: MAP and heart rate: HR) were measured in the anaesthetized rats by an invasive method. For this method, one carotid artery was catheterized, a pressure catheter (pressure volume Millar microtip catheter connected to the Mikro-Tip Pressure-Volume System from Ultra Foundation Systems, PowerLab) was inserted, and the blood pressure (MAP in mm Hg) and HR (beats/min) were monitored continuously during the experiment. For the neuropharmacological studies, antidepressant activity was assessed by forced swim test on the 15th day. Results: A dose-dependent significant increase in mobility time was observed in rats (G3-5) treated with HC + different doses of ATEL (p < 0.05). However, the mobility time was significantly reduced by HC (G2) treatment compared with that of the control (p< 0.05). The hypertensive control (high dietary salt: HC) group showed significant increases in SP, DP, MAP, and HR (p<0.05) compared to the control (G1) group. At all doses (50, 100 and 150 mg/kg), MAP and HR were found to decrease significantly (p<0.05) when compared with the values in the HC (G2) group. Further analysis revealed an improvement in heart rate variability (HRV) in ATEL-treated hypertensive rats. Conclusion: The present research suggests that increased dietary salt intake not only increases blood pressure significantly but also increases depression. ATEL contains some efficacious constituents, N, N-dimethyltryptamine (DMT: a 5-HT1A agonist) with predominant antidepressant and antihypertensive activity. Hence, ATEL appears to be a valuable plant extract that can be useful, at least as an adjunct, for therapy in patients who suffer from both depression and hypertension.


Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7538
Author(s):  
Narendar Dudhipala ◽  
Swetha Ettireddy ◽  
Ahmed Adel Ali Youssef ◽  
Goverdhan Puchchakayala

Irbesartan (IR) is an angiotensin II receptor antagonist drug with antihypertensive activity. IR bioavailability is limited due to poor solubility and first-pass metabolism. The current investigation aimed to design, develop, and characterize the cyclodextrin(s) (CD) complexed IR (IR-CD) loaded solid lipid nanoparticles (IR-CD-SLNs) for enhanced solubility, sustained release behavior, and subsequently improved bioavailability through oral administration. Based on phase solubility studies, solid complexes were prepared by the coacervation followed by lyophilization method and characterized for drug content, inclusion efficiency, solubility, and in vitro dissolution. IR-CD inclusion complexes demonstrated enhancement of solubility and dissolution rate of IR. However, the dissolution efficiency was significantly increased with hydroxypropyl-βCD (HP-βCD) inclusion complex than beta-CD (βCD). SLNs were obtained by hot homogenization coupled with the ultrasonication method with IR/HP-βCD inclusion complex loaded into Dynasan 112 and glycerol monostearate (GMS). SLNs were evaluated for physicochemical characteristics, in vitro release, differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD), and physical stability at room temperature for two months. The optimized SLNs formulation showed particle size, polydispersity index, zeta potential, assay, and entrapment efficiency of 257.6 ± 5.1 nm, 0.21 ± 0.03, −30.5 ± 4.1 mV, 99.8 ± 2.5, and 93.7 ± 2.5%, respectively. IR-CD-SLN dispersions showed sustained release of IR compared to the IR suspension and the IR-SLN dispersions. DSC results complimented PXRD results by the absence of IR endothermic peak. Optimized IR-CD complex, IR-SLN, and IR-CD-SLN formulations were stable for two months at room temperature. Thus, the current IR oral formulation may exhibit improved oral bioavailability and prolonged antihypertensive activity, which may improve therapeutic outcomes in the treatment of hypertension and heart failure.


2021 ◽  
Vol 23 (12) ◽  
pp. 191-206
Author(s):  
G. Swapna ◽  
◽  
K. Sesha Maheswaramma ◽  
K. Bhaskar Reddy ◽  
◽  
...  

Hypertension is considered a major health problems globally affect millions of patient.Various study confirms that single drug treatment usually is not adequate to achieve blood pressure goal in most hypertensive patients.In this regard,consideration is given to combination therapy, which offers the potential advantages towards minimizing hypertension in a rapid manner and produces lower adverse effects.SLTs (Sublingual tablets) provides immediate action to enhanced absorption and bioavailability rate. Sublingual tablets are absorbed within the mucus membrane and directly reach in blood systemic circulation. The objective of this ongoing research focused on theatenolol (ATN)and nifedipine (NIF) combined drug deliveryin emergency condition of hypertension. Direct compression technique is used to formulate SLTsby taking different types and concentrations of superdisintegrantsCroscarmellose sodium (CCS) and Crospovidone (CP). Sublimating agents like camphor (CM) and thymol (TY)) also added for better result. FTIR and DSC analysis confirms the ccompatibility results between drug and superdisintegrants.Formulated tablets are evaluated for different parameters and found satisfactory. Formulation F6 considered as the best formulation. The disintegration shows 13 sec and dissolution profile shows 97.36% drug release at 10 min. Formulation F6 shows better pharmacokinetic activity and antihypertensive activity in compare to pure drug and marketed formulation.A combination of ATN and NIF produces rapid disintegration and dissolution property during an emergency and is a lifesaving approach in hypertension treatment.


Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4232
Author(s):  
Emerson Nolasco ◽  
Mike Naldrett ◽  
Sophie Alvarez ◽  
Philip E. Johnson ◽  
Kaustav Majumder

Hen breed, diet enrichment, cooking methods, and gastrointestinal (GI) digestion modulates the bioaccessibility of the bioactive compounds in eggs, but their synergistic role in modulating bioactivity is still unclear. The present study evaluates the effect of hen breed, diet enrichment, and GI digestion on the cooked whole egg-derived peptides in-vitro antioxidant and antihypertensive activities. Standard and enriched whole eggs from White Leghorn (WLH) and Rhode Island Red (RIR) hens were boiled or fried and subjected to GI digestion. Antioxidant activity was measured through oxygen radical absorbance capacity (ORAC) and gastrointestinal epithelial cell-based assays, and the antihypertensive capacity by in-vitro Angiotensin-I Converting Enzyme (ACE) inhibition assay. WLH fried standard egg hydrolysate showed a high ORAC antioxidant activity but failed to show any significant antioxidant effect in the cell-based assay. No significant differences were observed in the antihypertensive activity, although enriched samples tended to have a higher ACE-inhibitory capacity. The peptide profile explained the antioxidant capacities based on antioxidant structural requirements from different peptide fractions, while previously reported antihypertensive peptides were found in all samples. The study validates the importance of physiologically relevant models and requires future studies to confirm mechanisms that yield bioactive compounds in whole egg hydrolysates.


Author(s):  
Valeria V. Kleandrova ◽  
Julio A. Rojas-Vargas ◽  
Marcus T. Scotti ◽  
Alejandro Speck-Planche

Molekul ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. 219
Author(s):  
Muharni Muharni ◽  
Heni Yohandini ◽  
Elfita Elfita ◽  
Fitrya Fitrya ◽  
Ani Sarah ◽  
...  

Flacourtia  rukam is a plant popular among people to treat hypertension, especially the Musi Banyuasin of south Sumatera, Indonesia. Isolation and identification of chemical compounds from F. rukam leaves and evaluation of their effects on antihypertensive activity have been conducted. Isolation of chemical compounds using chromatographic methods and identification using spectroscopic methods were compared with the reported data. The drug’s effects on antihypertension were determined using the  angiotensin converting enzyme (ACE) inhibitory method. Two compounds were first reported and isolated from the leaves of F. rukam and identified as apigenin (1) and lupeol (2). These compounds were demonstrated to be effective in treating antihypertension with IC50 656.51 ± 1.55 µg/mL for apigenin and 15.12 ± 0.72 µg/mL for lupeol. It can be concluded that  F. rukam leaves is a potential ACE inhibitor can be explored further as an effective antihypertensive agent.


Sign in / Sign up

Export Citation Format

Share Document