DNA methylation in peripheral tissues and Left-handedness

Handedness has low heritability and epigenetic mechanisms have been proposed as an etiological mechanism. To examine this hypothesis, we performed an epigenome-wide association study (EWAS) of left-handedness. In a meta-analysis of 3,914 adults of whole-blood DNA methylation, we observed that CpG sites located in proximity of handedness-associated genetic variants were more strongly associated with left-handedness than other CpG sites (P = 0.04), but did not identify any differentially methylated positions. We identified differentially methylated regions at 20q11.23 (P = 0.00004) and 2p25.1 (P = 0.03), which were less methylated in left-handed adults. In longitudinal analyses of DNA methylation in peripheral blood and buccal cells from children (N = 1,737), we observed moderately stable associations across age (correlation range [0.355–0.578]) but inconsistent across tissues (correlation range [-0.384-0.318]). We conclude that DNA methylation in peripheral tissues captures little of the variance in handedness. Future investigations should consider other more targeted sources of tissue, such as the brain.

Guidestar-free image-guided wavefront shaping

Optical imaging through scattering media is a fundamental challenge in many applications. Recently, breakthroughs such as imaging through biological tissues and looking around corners have been obtained via wavefront-shaping approaches. However, these require an implanted guidestar for determining the wavefront correction, controlled coherent illumination, and most often raster scanning of the shaped focus. Alternative novel computational approaches that exploit speckle correlations avoid guidestars and wavefront control but are limited to small two-dimensional objects contained within the “memory-effect” correlation range. Here, we present a new concept, image-guided wavefront shaping, allowing widefield noninvasive, guidestar-free, incoherent imaging through highly scattering layers, without illumination control. The wavefront correction is found even for objects that are larger than the memory-effect range, by blindly optimizing image quality metrics. We demonstrate imaging of extended objects through highly scattering layers and multicore fibers, paving the way for noninvasive imaging in various applications, from microscopy to endoscopy.

Spatial Pattern of Soil Carbon Density in Cultivated Land of Different Domains of Madhya Pradesh

Present study was conducted in the Department of Soil Science JNKVV, Jabalpur during 2018-2020. GPS based 531 soil samples were collected from each domain viz., Bhopal, Jabalpur, Vidisha and Hoshangabad of 10.1 Agro ecological sub region (AESR). The samples analyzed for soil organic carbon (SOC) and calcium carbonate (CaCO3) then soil organic carbon density (SOCD), total organic carbon density (TOCD), soil inorganic carbon density (SICD) and total carbon density (TCD) in Mg C ha-1 were calculated. The results of SOCD, TOCD, SICD and TCD ranged from 4.73 to 25.12, 9.22 to 48.98, 1.00 to 21.29 and 11.08 to 68.80 Mg C ha-1 with mean value of 12.19, 23.78, 7.58 and 31.36 Mg C ha-1 in AESR 10.1 and Coefficient of variation (CV) 37.58, 37.58, 50.88 and 31.24 %. The overall trend in SOCD was Bhopal > Vidisha > Jabalpur > Hoshanagabad and SICD was Vidisha > Hoshanagabad > Jabalpur >Bhopal while TCD was in trend of Bhopal > Vidisha > Hoshangabad> Jabalpur. Geo-statistical indicated that Ordinary Kriging used and all variogram were in isotropic form. In Bhopal domain, Gaussian model best fitted for of SOCD, TOCD, and TCD but spherical model for SICD. In Jabalpur domain, exponential domain best fitted for TCD and TOCD but for SICD, spherical model and for SOCD, Gaussian model is best fitted. In Vidisha domain, exponential model best fitted for all. In Hoshangabad domain, exponential model is best fitted for SOCD and TOCD and Gaussian and J-Bessel model best fitted for TCD and SIC, respectively. The nugget/ sill (N/S) ratio was <25% which exhibit strong SD only for SICD in Bhopal domain. The N/S ratio was found to be >25% but <75% which showed moderate SD, for SOCD, TOCD and TC, TOCD, SICD and TCD; SOCD, TOCD, SICD and TCD and SOCD, TOCD, SICD and TCD in Bhopal, Jabalpur, Vidisha and Hoshangabad domain, respectively. The correlation range (m) for SOCD, TOCD, SICD and TCD are 5448.413, 4809.535, 360.522, and 5113.050; 7201.044, 6601.044, 611.651, and 8438.711; 5734.559, 7334.398, 1323.773, and 7881.289 and 5418.684, 5433.206, 8887.656, and 1836.274 in Bhopal, Jabalpur, Vidisha and Hoshangabad domain, respectively. The carbon density was found in order of Jabalpur> Hoshangabad >Vidisha > Bhopal.

Relación entre la potencia y velocidad en press de banca y la velocidad de lanzamiento de balón en jugadores profesionales de balonmano (Relationship between barbell power and velocity in bench press exercise and ball throwing velocity in professional ha

Los objetivos de este estudio fueron (a) analizar la relación existente entre la una repetición máxima (1-RM) en press de banca y la velocidad de lanzamiento en jugadores de balonmano U18 de nivel internacional y, (b) analizar qué variables del ejercicio del press de banca son más relevantes en el rendimiento específico (velocidad de lanzamiento del balón) durante el test de velocidad de lanzamiento (T3-Step). Dieciséis jugadores de la Selección Española de Balonmano Juvenil participaron en la presente investigación. Todos los sujetos realizaron un protocolo incremental en el ejercicio del press de banca, además del T3-Step de velocidad de lanzamiento del balón. Por un lado, se analizó la relación existente entre la velocidad media (Velmedia), velocidad media de la fase propulsiva (VelMFP), velocidad pico (Velpico), potencia media (Potmedia), potencia media de la fase propulsiva (PotMFP), y potencia pico (Potpico) en todo el espectro de cargas en relación con la velocidad de lanzamiento. También se realizaron los mismos análisis con la carga en donde se obtuvo la máxima potencia media (CargaMP). Los resultados mostraron, por un lado que el rango de correlación de la CargaMP, PotmediaMP, PotMFPMP y PotpicoMP y la velocidad de lanzamiento fueron de .61 (p= .012), .702 (p< .01), .734 (p< .01) y .63 (p< .01), respectivamente. El coeficiente de correlación de Pearson entre la 1-RM y la velocidad de lanzamiento fue de r = .61 (p < .01). En conclusión, las variables relevantes a nivel de rendimiento específico con la velocidad de lanzamiento fueron la 1RM, la CargaMP, la PotMFPMP y la VelMFPMP. Todas estas analizadas en función del 60% de la 1-RM. Abstract. The objectives of this study were (a) to analyze the relationship between one repetition maximum (1-RM) in free bench press exercise and ball throwing velocity in handball players U18 of international level and, (b) to analyze which variables of bench press exercise are more relevant in the specific performance during the ball throwing velocity test (T3-Step). Sixteen (n = 16) players of the Spanish Youth Handball Team participated in the present investigation. All subjects included performed an incremental protocol bench press exercise, in addition to the T3-Step. On the one hand, it analyzed the relationship between the mean velocity (Velmean), the mean velocity of propulsive phase (VelmeanPP), peak velocity (Velpeak), the average power (Powermean), the average power of the propulsive phase (PowermeanPP), and peak power (Powerpeak) over the entire spectrum of charges in relation to the launch speed. The same analyzes were also obtained with the load where the maximum average power (LoadMP). The results obtained, on the one hand that the correlation range of the LoadMP, PowermeanPP, PowerMPPMP and PowerpeakPP and ball throwing velocity were .61 (p = .012), .70 (p < .01), .73 (p < .01) and 0.63 (p < .01), respectively. The correlation coefficient between the 1-RM and ball throwing velocity was r = 0.61 (p< .01). In conclusion, the relevant variables at the specific performance level with the ball throwing velocity were 1-RM, LoadMP, PowerMFPMP and VelMFPMP. All these analyzed according to 60% of the 1-RM.

The impact of groundwater depth on the spatial variance of vegetation index in the Erdos Plateau, China

&lt;p&gt;As important sensitive feedback of ecosystems, spatial distribution and patterns of vegetation can remarkably reflect eco-environmental conditions in arid and semiarid areas, where groundwater plays a significant role. The impact of groundwater depth (GD) on the spatial variance in remote-sensing vegetation index is highlighted in this study over the Erdos Plateau, China. The 250 m resolution mean annual Enhanced Vegetation Index (EVI) data in the period 2000-2010 are analyzed and compared to the same resolution data of GD. It is indicated from the semivariogram that the correlation range of EVI (10-22 km) is close to the correlation range of GD (9-19 km) and both of them show a near to zero nugget. The semivariance of EVI generally decreases with the increasing GD from 0 m to 10 m, but the relationship could be disturbed by other factors. In the semiarid region of the study area where the aridity index falls between 3 and 5, the 98&lt;sup&gt;th&lt;/sup&gt; percentile EVI which represents high density vegetation decreases nonlinearly with the increasing GD from 0 m to 7 m. In the arid region where the aridity index is higher than 5, EVI is relatively low and almost independent on groundwater. The 50&lt;sup&gt;th&lt;/sup&gt; percentile EVI is generally not sensitive to GD, especially in the arid region. Thus, the spatial variance of vegetation is a synthetic result of the climatic and hydrogeological conditions, which should be considered in the regulation of groundwater resources at the regional scale for ecological benefits.&lt;/p&gt;

The Role of Item Distributions on Reliability Estimation: The Case of Cronbach’s Coefficient Alpha

Simulations concerning the distributional assumptions of coefficient alpha are contradictory. To provide a more principled theoretical framework, this article relies on the Fréchet–Hoeffding bounds, in order to showcase that the distribution of the items play a role on the estimation of correlations and covariances. More specifically, these bounds restrict the theoretical correlation range [−1, 1] such that certain correlation structures may be unfeasible. The direct implication of this result is that coefficient alpha is bounded above depending on the shape of the distributions. A general form of the Fréchet–Hoeffding bounds is derived for discrete random variables. R code and a user-friendly shiny web application are also provided so that researchers can calculate the bounds on their data.

Using Mobile– iPhone as New Visible Colour Detector for Determination of Pharmaceutical (Potassium Permanganate)

In this work the use of a mobile phone as a spectrophotometer using camera resolution by installing the software (application store AAP) on the phone (i Phone 6), which analyzes the colour images (RGB) in results with a colour length where it was possible to calculate the colour value of each image representing a specific concentration of the solution under study. A calibration curve with a range of (1 × 10-3 - 6.25 × 10-4) mmole.L-1 using optical image analysis with the concentration of the preparation of potassium permanganate (KMnO4). A calibration curve for statistical correlation range of 0.993 (R2) was found.

HUBUNGAN KANDUNGAN BAHAN ORGANIK DENGAN KELIMPAHAN DAN KEANEKARAGAMAN GASTROPODA PADA KAWASAN WISATA MANGROVE DESA BEDONO DEMAK Relation of Organic Matters to the Abundance and Diversity of Gastropods in the Mangrove Tourism Areas of Bedono, Demak

ABSTRAK Wilayah pesisir Bedono sebagai kawasan hutan bakau yang terletak di utara Kabupaten Demak telah dikelola dan dijadikan kawasan wisata sehingga secara tidak langsung akan berdampak terhadap fungsi ekologis mangrove. Banyak organisme hidup yang berasosiasi dengan mangrove salah satunya adalah Gastropoda. Tujuan dari penelitian ini adalah mengetahui jenis Gastropoda, kelimpahan dan keanekaragaman Gastropoda serta mengetahui hubungan antara kandungan bahan organik dengan kelimpahan Gastropoda. Pengambilan sampel Gastropoda dan sedimen dengan metode kuadran transek yaitu 1 x 1m di 3 stasiun. Hasil penelitian didapatkan terdiri dari 5 genera Gastropoda yaitu Cassidula sp, Cerithidae sp, Littorina sp, Telescopium sp, dan Terebralia sp. Kelimpahan Gastropoda berkisar antara 94 – 248 ind/3m2. Nilai indeks keanekaragaman sebesar 1,08 - 1,27. Nilai indeks keseragaman sebesar 0,67 – 0,94 dan indeks dominasi sebesar 0,23 – 0,39. Berdasarkan nilai uji regresi sederhana dimana nilai koefisien korelasi berkisar 0,7 < r ≤ 1,0 menunjukkan bahwa kelimpahan gastropoda memiliki hubungan yang kuat dan memiliki korelasi dengan kandungan bahan organik dalam sedimen. ABSTRACT Bedono coastal as an area mangrove forest located at the northen Demak Regency has been managed and used as a tourism area. Many living organisms associated to mangrove, mainly Gastropods. Purpose the research a to investigate type of Gastropods, abundance and diversity of Gastropods and relationship of organic matters to Gastropods abundance. Samples of Gastropods and sediments were collected using 1x1m transect quadrant methods in 3 different stations. Results of research obtained 5 genera of Gastropods that is Cassidula sp, Cerithidae sp, Littorina sp, Telescopium sp, dan Terebralia sp. Abundance of Gastropods between 94 – 248 ind/3m2. Result of diversity index was 1,08 – 1,27. Uniformity index between 0,67 – 0,94 and domination index was 0,23 – 0,39. Based on simple regression test the value of a correlation range 0,7 < r ≤ 1,0. It was showed that gastropods abundance have a close relationship and a correlation with organic matters in sediments.