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Published By Scires Literature LLC

2766-2276
Updated Tuesday, 06 July 2021

Author(s):  
Zubair SM ◽  
Muhammad Zaid HH ◽  
Talha S

A 71 years old male came to the hospital with the complaint of cough and fever since 7 days. He was diagnosed with severe COVID pneumonia and was managed with steroids and tocilizumab. He was discharged on steroids and came after 20 days with complaints of worsening shortness of breath and hypoxia. Bronchoscopy and bronchoalveolar lavage was done which showed positive PCR for Pneumocystis Jirovecii Pneumonia (PCP). Patient was started on co-trimoxazole and steroids after which he showed remarkable improvement. This is one of the rare cases in which patient developed PCP as a sequelae of COVID-19.


Author(s):  
Sayantan G

Background: Leukemia is one of the most occurring haematological pathologies in the world which develops due to the impairment in the hematopoietic machinery. Cellular death via apoptosis is severely impaired in this pathophysiological condition and leads to the progression of the disease. Objective: We have tried to unearth the efficacy of Withanolide D, a steroidal lactone derived from Withania somnifera or Ashwagandha on some of the apoptotic machinery components, i.e. TERT, BCL2 and PUMA in the experimental leukemic mice. Materials and Methods: LD50 and EC50 values of Withanolide D were estimated. Three groups of animals were taken for experimental purpose i.e. Group I = Leukemic, (L); Group II = Control, (C); Group III = Leukemic treated with Withanolide D, (L + WD). Group III received Withanolide D via oral route and other two groups received equal volume of distilled water. Various cytological, immunofluorescence and flow cytometric studies were taken into consideration post administration. Result: Leukemic group showed increased cellular proliferation and decreased cellular death as compared to control. Post Withanolide D administration TERT, BCL2 and PUMA expression started to shift towards normal status. This shift in the expressional values of increased apoptosis rate and decreased cellular proliferation revealed by cytological, immunofluorescence studies and flow cytometric investigations. Conclusion: As Withanolide D decreased the suppression of apoptosis and impaired the progression of the disease, so, we can conclude that Withanolide D of Ashwagandha may hold a promise towards a new therapeutic strategy in leukemia.


Author(s):  
Gunduz T ◽  
Cakir M ◽  
Bakirci EM ◽  
DEGIRMENCI H

Heparin-İnduced Thrombocytopenia (HIT) is a life-threatening complication that occurs in a small percentage of exposed patients (e.g. unfractionated heparin, Low Molecular Weight Heparin [LMWH]) regardless of dose and treatment management.


Author(s):  
Bolley A

Since 1940, mass production of polyolefin plastics produced annually has increased rapidly [1]. The most common plastics, which account for approximately 80% of the European plastic demand, are: Polyethylene (PE), Polypropylene (PP), Poly (Vinyl Chloride) (PVC) and Polystyrene (PS) (Figure 1) [2]. Therefore, plastic materials have experienced a substantial expansion, and are the most used materials nowadays. These materials have a wide range of application from packaging to electronic devices [3].


Author(s):  
Sadeghi S

Multiple Sclerosis (MS) has been defined as an inflammatory demyelinating condition afflicting more than 2.8 million people worldwide. Meta-regression analyses of studies on MS epidemiology since 1965 revealed an almost universal increase in prevalence and incidence of MS over time; and suggest a general increase in incidence of MS in females.


Author(s):  
Barchín JL ◽  
Wikman-Jorgensen PE ◽  
Bello L ◽  
Pascual R

Introduction: Community-acquired pneumonia is a prevalent disease that is managed in heterogeneous ways. Clinical pathways have been proposed as one way to mitigate this variability, but few implementation experiences have been published. The primary objective of this study is to analyse the effects of implementing a standardised clinical pathway for community-acquired pneumonia on length of hospital stay. Methods: Retrospective cohort study comparing two equivalent time periods with and without a clinical pathway. We described patient characteristics in both periods and compared mean length of hospital stay, mortality, rate of complications, and readmissions within 30 days. Results: A total of 170 patients were included across both periods. Mean length of hospital stay in patients treated before implementation of the clinical pathway was 6.05 days versus 5.43 days afterward (p = 0.28). The segmented regression analysis showed a change in slope for the length of hospital stay (0.04) following implementation of the clinical pathway. The proportion of patients hospitalised for more than 6 days was 37.5% in the first period, compared to 29.6% in the second (p = 0.088). Multivariable analysis showed that nonadherence to the clinical pathway was associated with a hospital stay of longer than 6 days (p = 0.048). Mortality dropped from 10.5% to 4.7% after the clinical pathway was established (p = 0.12). The proportion of patients readmitted within 30 days due to CAP was 8.8% before the establishment of the clinical pathway and 0% afterwards (p = 0.006). Conclusion: A clinical pathway for managing community-acquired pneumonia was associated with a reduction in length of hospital stay and readmittance. There was a trend towards mortality reduction.


Author(s):  
Ameri E ◽  
Shariati FP ◽  
Amrei HD

Finding new antimicrobial agents from natural compounds with less side effects has been considered by number of researchers in the world. It is important to achieve efficient and up-to-date results in order to identify a substance with antimicrobial properties and achieve operational methods to increase these traits in a society where the prevalence of various diseases has been increased. In fact, the purpose of this study was to achieve compounds from microalgae with antimicrobial properties to be used in food and pharmaceutical industries that can have good consequences for human health. Therefore, in the current study antimicrobial activity of ethanolic extract of microalgae Chlorella sp., that was cultivated under different light conditions, was investigated. For this purpose, microalgae Chlorella sp. was separately cultivated under red, blue, green and white lights with intensity of 109 (μmol-photon m-2 s-1) and antimicrobial potential of the microalgae extracts investigated against the activity of Streptococcus mutans. In addition, Minimal Inhibitory Concentration (MIC) of the extracts determined. Based on the results, the wet extracts indicated more average antimicrobial activity than dried ones. Furthermore, the wet extract of microalgae cultivated under the red light showed a stronger antimicrobial activity compared to extract obtained under the other light spectrum with the minimum inhibitory of that was 10 mg/ml. Also, extract obtained under white light had no significant antibacterial activity against the bacterial strain.


Author(s):  
Siblerud R ◽  
Mutter J

Aim: The purpose of this paper is to summarize the research regarding the toxic health effects caused by mercury dental amalgams. Method: The study involved summarizing scientific articles in journals regarding health effects of dental amalgam mercury. Results: The science strongly suggests dental amalgam mercury may be an etiological factor in numerous health disorders. Mental health seems to be affected the most including such conditions as depression, anger, and irritability. Studies have also associated it with schizophrenia and bipolar disorders. The cardiovascular system also is affected including high blood pressure, heart rate, hemoglobin, hematocrit, and red blood cells. Subjects with amalgams have a decreased T lymphocyte percentage compared to a control, and the immunoglobins IgG, IgA, and IgE correlated with the number of amalgams. Myopia is reduced in amalgam bearing subjects but amalgam mercury is constricting the visual field. When comparing total health disorders of subjects with amalgams compared to those without, they suffered 45% more health disorders. Urine and hair mercury levels were significantly higher in subjects with amalgams compared to those without. The scientific evidence strongly suggests that amalgam mercury is associated with Alzheimer’s disease, multiple sclerosis, and amytrophic lateral sclerosis. Research has shown when amalgams are removed many health conditions improve. Conclusion: The evidence is overwhelming that mercury from dental amalgam is an etiological factor in many health disorders.


Author(s):  
Meider J ◽  
Messal C

Taking a tape-lift sample is one of the main practices used by indoor environmental quality investigators for detecting whether mould structures (for example, spores and hyphae) have either settled onto or colonized the surface. Despite the popularity of the method, there can be significant inconsistency in how tape lifts are collected and evaluated. The common ASTM standard D7910-14: Practice for the Collection of Fungal Material from Surfaces by Tape Lift, describes the correct way to collect a tape-lift sample. Using ASTM D7658-17: Standard Test Method for Direct Microscopy of Fungal Structures from Tape, semi-quantitative results in percentage of infested area in a scale from 0 up to 5 are available only. In case histories or for mould removal control, the total cell count is needed. This cannot be realized by the ASTM method. Therefore, an innovative method is asked to combine the quickness of taping and the precision of total cell count. Our research team developed two methods to quickly and fully quantify the tape samples. Regarding the assessment criteria, the user can decide to operate with the 3-LINE method to achieve the highest precision or use the faster 3-STEP method for even better results. Therefore, an innovative method is asked to combine the quickness of taping and the precision of total cell count. The aim of the work is to develop two strategies to quickly and comprehensive quantify the tape samples.


Author(s):  
Osman NA ◽  
Bedwani RN ◽  
Shehata GM ◽  
Emam MM ◽  
Rabie AM

Introduction: The undisputed increase of the relevance of measuring the work-related psychosocial factors is confronted with a lack of qualified well-documented measuring instruments covering all important aspects. Aim: To develop and validate a standardized Arabic version of the COPSOQ II for evaluating the psychosocial environment at the oil and gas workplace. Method: COPSOQ network guidelines for validation studies were followed. The original Danish COPSOQ II (Long version) was meticulously translated and comprehensively validated among an adaptation sample of 500 oil and gas industry workers in the Suez Oil Processing Company in Egypt. Only 438 workers completed the questionnaire in Arabic and English languages with demonstrated sociodemographic data (Yielding a response rate of 87.6%). Psychometric properties of COPSOQ II scale items were depicted in terms of descriptive statistics, feasibility analysis, and internal consistency. Furthermore, A-COPSOQ II was tested for factorial validity using exploratory and confirmatory factor analysis. Results: Mean age of the study participants was 35 ± 6 years. Scales of Arabic COPSOQ depicted a great Concordance and Reliability (C-α > 0.7). Content Validity Index (CVI) was estimated to be 0.87; ranging from 0.7 - 0.9. Models of exploratory factor analyses projected a reflective working model with reasonable results in 33 out of 41 overall scales. Confirmatory factor analysis revealed an acceptable fit (X2 = 745.67, X2/df = 2.09, SRMR = 0.058, CFI = 0.87). Conclusion: Arabic version of COPSOQ II is a relevant and culturally accepted conceptual instrument for tracking psychosocial hazards and promoting a safe environment for all workers.


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