Oncological issues of hormonal contraception and hormone replacement therapy

The article gives critical analysis of numerous epidemiological studies touching upon the problems of carcinogenesis while using hormonal contraception and hormonal replacement therapy and also the expediency of HRT as to oncologic patients after radical treatment.The materials presented testify to relative carcinogenous safety of hormonal contraceptives as to the majority of tumors and even considerable decrease of endometrial and ovarian cancer risk; but some investigations point to the increase о f breast cancer in case о f prolonged application о f hormonal preparations.The results оf the analysis show that HR Tmay be recommended among female population providing active screening, especially of mammary glands and endometrium. Besides that, hormonal preparations are not excluded for rehabilitation of some oncologic patients underthorough monitoring. Yet, there exists burning necessity of continuing cooperated scientific and clinical investigations forfurther studying oncologic aspects of hormonal contraception and HRT.

Modern approaches to endoscopic hysterectomy

The new method of radical uterine surgery combining endoscopic approachand minilaparotomy is represented. 105 operative invasions on the uterus were performed using this method. Characteristic features of the surgical method, which was elaborated, are minimum blood loss and tissue injury, simple technique, low requirement of analgetics, fast rehabilitation of patients activity and capacity for work, using common equipments and materials.

Endoscopy in the preservation and restoration of reproductive function

The new method of radical uterine surgery combining endoscopic approachand minilaparotomy is represented. 105 operative invasions on the uterus were performed using this method. Characteristic features of the surgical method, which was elaborated, are minimum blood loss and tissue injury, simple technique, low requirement of analgetics, fast rehabilitation of patients activity and capacity for work, using common equipments and materials.

Hormonal contraception for women with type 1 diabetes

The investigation demonstrates the influence ofperoral combined contraceptives and preparations containing only progestagens on carbohydrate and lipid exchange and haemostatic system. The factors, which exert influence upon metabolic indices in women with type I insular diabetes, are estimated. The correlation between the intake of combined and containing only progestagens contraceptive preparations and the risk of tromboembolism is revealed. The indications and contraindications are defined for the prescription of peroral contraceptives in women with type I insular diabetes.

To the problem of pregnant women's cholestasis

Liver disease andpregnancy usually aggravates each other. Its rather difficult to differentiate pregnant womens cholestasis from gestosis accompanied with chronic liver disease preceding pregnancy. 60 pregnant women were examined, the first group with cholestatic hepatosis, the second group with gestosis and liver disease. The practical aim o f the study was to choose righttactics o f pregnancy management, method and date o f confinement.Pregnant womens hepatosis turned out to be a complex concept: it may embrace different types o f pathological pregnancy under the single clinical diagnosis.

Doctor, teacher and scientist (in memory of Professor Viktor Pavlovich Baskakov)

On November 11, 2001, at the age of 78, Doctor of Medical Sciences, Professor Viktor Pavlovich Baskakov, suddenly died. It is difficult to get used to the thought and hard to realize that there is no longer this life-loving person among us, a magnificent obstetrician-gynecologist, a prominent scientist and talented teacher.

On the clinical significance of biovars ureaplasma urealyticum

Developing of chronic salpingoophoritis, non-specific bacterial vaginitis and specific candidamytotic vaginitis ought to be associated with complicated obstetric anamnesis and presence of biovar Parvo ureaplasmas predominantly found in womens genital tracts. The correlation may be seen between identifying biovar Parvo ureaplasmas in men and arising of torpid and chronic infectious urethritis, that may testify to its more intensive pathogenic effect comparing with biovar T- 9GO. Detection of biovar T-960 in urogenital system in men and women doesnt exclude the possibility of inflammation, that implies adequate complex therapy identical to that in case of biovar Parvo.

Puerperal form ation of vaginal microbiocenosis using various eubiotic preparations

The results of determination of the efficiency of liquid eubiotic preparations, such as Lactobacterin, Bifidumbacterin, Bificol, Colibacterin applied for the normalization of genital microflora in women after labor are presented in the article. The use of a combined eubiotic preparation containing both lactobacilli and bifidobacterii may be recommended.

Hydrolytic enzymes in therapy of gestosis

The clinical effectiveness o f complex enzymotherapy with preparation Vobenzim in treatment o f gestosis was studied in comparison with traditional therapy. The author analyzes the course оf gestation and delivery, and the state оf neonates in women with nephropathy o f I degree, who got common treatment (28 patients) and complex treatment including Vobenzim (17patients). Positive clinical effect o f complex enzymotherapy in case o f nephropathy is displayed in decreasing of edematic syndrome, eliminating or decreasing o f proteinuria, lowering o f blood pressure and impairment o f fetalhypoxia in labors. It goes along with the reduction o f immune complexes fixed in placenta.

Clinical characteristics of patients with reproductive dysfunction and benign ovarian neoplasms

The study reports on the analysis of the anamnestic data of2044 women with reproductive disorders who underwent operative interventions for tumors and tumorlike masses of the ovaries during the period of 1989-1999 in the Research Center of Obstetrics, Gynecology and Perinatology of the Russian Academy of Medical Sciences. A high incidence rate о f complicated anamnesis and the coexisting somatic and extragenital diseases was revealed. The data are presented concerning the status of menstrual and reproductive function of the patients examined.