The Diagnostic Value of Determination of Intraerythrocytic Sodium and Potassium Concentrations versus Plasma Digoxin Concentration in Digoxin Intoxication

2009 ◽  
Vol 213 (5) ◽  
pp. 357-362 ◽  
Author(s):  
K. E. Pedersen ◽  
O. Koldkjaer ◽  
N. H. Berndtz ◽  
S. Hvidt ◽  
K. Kjaer ◽  
...  
Keyword(s):  
Digoxin Concentration ◽  
Diagnostic Value ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration ◽  
Digoxin Intoxication ◽  
Sodium And Potassium

Peak Plasma Digoxin Concentration and Cardiotoxicity

1978 ◽  
pp. 273-283 ◽  
Author(s):  
B. F. Johnson ◽  
D. J. Chapple ◽  
R. Hughes ◽  
J. LaBrooy ◽  
I. Smith
Keyword(s):  
Peak Plasma ◽  
Digoxin Concentration ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration

Digoxin toxicit in chronic renal failure: treatment by multiple dose activated charcoal intestinal dialysis

1997 ◽  
Vol 16 (12) ◽  
pp. 733-735 ◽  
Author(s):  
Julian AJH Critchley ◽  
Lester AH Critchley
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Activated Charcoal ◽  
Multiple Dose ◽  
Digoxin Concentration ◽  
Digoxin Toxicity ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration ◽  
Wide Range ◽  
Repeated Doses

1 Digoxin toxicity can result from overdose or iatrogenic causes, especially if renal function is impaired. 2 We present a case of digoxin toxicity presenting with severe bradycardia and hypotension in a 66 year old man with chronic renal failure. Regular haemodia lysis had, as predicted, failed to reduce his plasma digoxin concentration. Digoxin specific antibody fragments (Fab) were not readily available and their use was probably inappropriate as they are normally renally eliminated. 3 The patient was successfully treated by two prolonged courses of intestinal dialysis with repeated doses of activated charcoal over 48 and 72 h and totaling 400 g and 600 g, respectively. However, the patient found the activated charcoal extremely unpalatable. 4 Multiple dose activated charcoal intestinal dialysis (MDACID) has been recently advocated for use in a wide range of poisonings. The technique takes advantage of the large surface area of the small intestine to eliminate drugs and metabolites, over several days if necessary. The pharmacokinetics of digoxin toxicity in chronic renal failure make intest inal dialysis an appropriate method of treatment but the realisation of the true potential of this technique awaits a more palatable absorbent or formulation.

scholarly journals Evaluating plasma Digoxin concentration after an intravenous loading dose in patients with renal failure

2021 ◽  
pp. 033-037
Author(s):  
Eslami Vahid ◽  
Mortezapour Fatemeh ◽  
Samavat Shiva ◽  
Ziae Shadi ◽  
Gheymati Azin
Keyword(s):  
Renal Failure ◽  
Digoxin Concentration ◽  
Loading Dose ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration

Effect of Quinine on Plasma Digoxin Concentration and Renal Digoxin Clearance

2009 ◽  
Vol 218 (2) ◽  
pp. 229-232 ◽  
Author(s):  
KNUD ERIK PEDERSEN ◽  
JAN LYSGAARD MADSEN ◽  
NIELS ANDERS KLITGAARD ◽  
KAREN KJAER ◽  
STEFFEN HVIDT
Keyword(s):  
Digoxin Concentration ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration ◽  
Digoxin Clearance
Sign in / Sign up

Export Citation Format

Share Document