A Postresection Perfusion Deficit in the Right Colon is an Independent Predictor of Perioperative Outcome after Major Hepatectomy

Background and Aims: The importance of sessile serrated lesions (SSLs) in the pathogenesis of colorectal carcinoma has been recently established. These are supposed to cause the so-called “interval cancer”, having a rapidly progressive growth and being difficult to detect and to obtain an endoscopic complete resection. We aimed to establish the most important metabolic risk factors for sessile serrated lesions. Methods: We performed a retrospective case-control study, on a series of 2918 consecutive patients who underwent colonoscopy in Gastroenterology and Endoscopy Unit, County Clinical Emergency Hospital, Târgu-Mureș, Romania between 1 st of January 2015-31 th of December 2017. In order to evaluate the metabolic risk factors for polyps’ development, enrolled participants were stratified in two groups, a study group, 33 patients with SSLs lesions, and a control group, 138 patients with adenomatous polyps, selected by systematic sampling for age and anatomical site. Independent variables investigated were: gender, smoking, alcohol consumption, obesity, arterial hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia, hyperuricemia, nonalcoholic liver disease. Results: For SSLs the most common encountered localization was the right colon in 30.55% of cases. By comparative bivariate analysis between SSLs group and control group, it was observed that hypertension (p=0.03, OR 2.33, 95 %CI 1.03-5.24), obesity (p=0.03, OR 2.61, 95 %CI 1.08-6.30), hyperuricemia (p=0.04, OR 2.72, 95 %CI 1.28-7.55), high cholesterol (p=0.002, OR 3.42; 95 %CI 1.48-7.87), and high triglycerides level (p=0.0006, OR 5.75; 95 %CI 1.92-17.2) were statistically associated with SSLs development. By multivariate analysis hypertension and hypertriglyceridemia retained statistical significance. Conclusions: Our study showed that the highest prevalence of SSLs was in the right colon and hypertension and increased triglycerides levels were associated with the risk of SSLs development. These risk factors are easy to detect in clinical practice and may help identifying groups with high risk for colorectal cancer, where screening is recommended.

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Impact of second forward-view examination on adenoma detection rate during unsedated colonoscopy: a randomized controlled trial

BMC Gastroenterology ◽

10.1186/s12876-021-01783-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Keshu Shan ◽

Hongpeng Lu ◽

Zhixin Zhang ◽

Jiarong Xie ◽

Lu Xu ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Detection Rate ◽

Controlled Trial ◽

Lesion Detection ◽

Adenoma Detection Rate ◽

Right Colon ◽

Randomized Controlled ◽

Adenoma Detection ◽

Advanced Lesion ◽

The Right

Abstract Objectives Colorectal cancer on the right side of the colon has been suggested to be harder to detect by colonoscopy. The aim of this study was to evaluate whether a second forward-view examination of the right side of the colon could increase the adenoma detection rate (ADR) and/or polyp detection rate (PDR). Methods This was a single-centre randomized controlled trial. Patients undergoing colonoscopy were recruited and randomly assigned to the second forward-view examination (SFE) group, in which the right side of the colon was examined twice or the traditional colonoscopy (TC) group in which the colonoscopy was performed in a standard manner. The primary outcome was the ADR of right colon. The overall PDR and ADR, PDR of the right colon, per-adenoma miss rate of the right colon, and advanced lesion detection rate were also recorded and compared. Results A total of 392 patients were included in the study (SFE group 197 vs. TC group 195). The ADR and PDR of the right colon in the SFE group were significantly higher than those in the TC group (ADR 10.7% vs. 5.1%; P = 0.042); PDR 17.8% vs. 9.7%, P = 0.021). No significant difference was found in overall PDR/ADR, or advanced lesion detection rate between the two groups. Conclusions This prospective controlled study revealed that a second forward-view examination could modestly increase the ADR and PDR of the right colon during unsedated colonoscopies. This simple, safe and time-effective technique might be recommended for routine unsedated colonoscopy. Trial registration: Clinical Trials.gov, NCT03619122. Registered on 7/8/2018.

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Sessile serrated adenoma invading a diverticulum in the right colon: tips and tricks for a safe complete endoscopic resection

Endoscopy ◽

10.1055/a-1463-2045 ◽

2021 ◽

Author(s):

Sophie Geyl ◽

Jérémie Albouys ◽

Romain Legros ◽

Hugo Lepetit ◽

Martin Dahan ◽

...

Keyword(s):

Endoscopic Resection ◽

Tips And Tricks ◽

Right Colon ◽

Sessile Serrated Adenoma ◽

Serrated Adenoma ◽

The Right

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Racial Disparities in Epigenetic Aging of the Right vs Left Colon

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/djaa206 ◽

2020 ◽

Author(s):

Matthew Devall ◽

Xiangqing Sun ◽

Fangcheng Yuan ◽

Gregory S Cooper ◽

Joseph Willis ◽

...

Keyword(s):

Dna Methylation ◽

African Americans ◽

Racial Differences ◽

Age Of Onset ◽

Left Colon ◽

Right Colon ◽

Normal Colon ◽

Epigenetic Aging ◽

Epigenetic Age Acceleration ◽

The Right

Abstract There are well-documented racial differences in age-of-onset and laterality of colorectal cancer. Epigenetic age acceleration is postulated to be an underlying factor. However, comparative studies of side-specific colonic tissue epigenetic aging are lacking. Here, we performed DNA methylation analysis of matched right and left biopsies of normal colon from 128 individuals. Among African Americans (n = 88), the right colon showed accelerated epigenetic aging as compared to individual-matched left colon (1.51 years; 95% CI = 0.62 to 2.40 years; two-sided P = .001). In contrast, among European Americans (n = 40), the right colon shows remarkable age deceleration (1.93 years; 95% CI = 0.65 to 3.21 years; two-sided P = .004). Further, epigenome-wide analysis of DNA methylation identifies a unique pattern of hypermethylation in African American right colon. Our study is the first to report such race and side-specific differences in epigenetic aging of normal colon, providing novel insight into the observed younger age-of-onset and relative preponderance of right-side colon neoplasia in African Americans.

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Results of resection of the right colon for volvulus

coloproctology ◽

10.1007/bf03043876 ◽

1998 ◽

Vol 20 (5) ◽

pp. 205-208

Author(s):

Jean-Jacques Tuech ◽

Christophe Binelli ◽

Patrick Pessaux ◽

Frederic Villapadierna ◽

Jean Ronceray ◽

...

Keyword(s):

Right Colon ◽

The Right

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Utility of mobilization of the right colon and the root of the mesentery for avoiding vein grafting during reconstruction of the portal vein 1 1No competing interests declared.

Journal of the American College of Surgeons ◽

10.1016/s1072-7515(01)01039-0 ◽

2001 ◽

Vol 193 (5) ◽

pp. 576-578 ◽

Cited By ~ 21

Author(s):

Shigeru Fujisaki ◽

Ryouichi Tomita ◽

Masahiro Fukuzawa

Keyword(s):

Portal Vein ◽

Right Colon ◽

Competing Interests ◽

The Right

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P.03.10 LINKED COLOR IMAGING (LCI) REDUCES THE MISS RATE OF NEOPLASTIC LESIONS IN THE RIGHT COLON: A RANDOMIZED TANDEM COLONOSCOPY STUDY

Digestive and Liver Disease ◽

10.1016/s1590-8658(18)30450-x ◽

2018 ◽

Vol 50 (2) ◽

pp. e147

Author(s):

G. Mogavero ◽

S. Paggi ◽

A. Amato ◽

A. Andrealli ◽

G. Imperiali ◽

...

Keyword(s):

Right Colon ◽

Color Imaging ◽

Neoplastic Lesions ◽

Linked Color Imaging ◽

The Right

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Metastasis of the right colon mucinous adenocarcinoma to aortocaval and retropancreatic space: case report and literature review

Khirurgiya Zhurnal im N I Pirogova ◽

10.17116/hirurgia202106295 ◽

2021 ◽

pp. 95

Author(s):

A.L. Bedzhanyan ◽

M.I. Bredikhin ◽

T.N. Galyan ◽

D.E. Arutyunyants ◽

K.N. Petrenko ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Mucinous Adenocarcinoma ◽

Right Colon ◽

Space Case ◽

The Right

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Gangrene of the right colon after blast injury caused by abdominal gunshot wounds

Vojnosanitetski pregled ◽

10.2298/vsp0506483i ◽

2005 ◽

Vol 62 (6) ◽

pp. 483-485

Author(s):

Dragan Ignjatovic ◽

Sidor Misovic ◽

Miodrag Jevtic

Keyword(s):

Case Report ◽

Primary Anastomosis ◽

Gunshot Wounds ◽

Pancreatic Injury ◽

Blast Injury ◽

Blast Injuries ◽

Right Colon ◽

Terminal Ileostomy ◽

The Right ◽

Abdominal Gunshot Wounds

Aim. To present a patient with an indirect secondary nonperforating blast injury of the right colon following abdominal gunshot injury, which led to necrosis and the right colon gangrene, and was surgically managed. Case report. A 26-year-old male was shot in the abdomen by four projectiles causing the secondary indirect blast injury of the right colon that turned into gangrene after 24 hours. Two days after admission, laparotomy was performed, but the primary anastomosis was not done because of the stomach and pancreatic injury, and the resection of the colon with terminal ileostomy was done instead. Three months later, the reconstruction of the colon was performed using ileocolotransverso-terminolatetral anastomosis. Conclusion. Secondary blast injuries should be anticipated in gunshot injuries, and could be expected to any organs, particularly the air filled ones.

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Obstructed descending colon mass pretended with Bockdalek hernia: a case report

10.21203/rs.3.rs-369079/v1 ◽

2021 ◽

Author(s):

mohammad eslamian ◽

Mohsen kolahdouzan

Keyword(s):

Diaphragmatic Hernia ◽

Abdominal Pressure ◽

Right Colon ◽

Abdominal Ct ◽

Midline Laparotomy ◽

Abdominal Ct Scan ◽

Descending Colon ◽

The Right ◽

Thoracic And Abdominal ◽

Diaphragmatic Hernias

Abstract Introduction: Adult Bochdalek hernia is one of the right-sided diaphragmatic hernias that less than 30 cases reported until now.Case: I herein report a 64-year-old female patient who had dyspnea, abdominal pain, and nausea. Primary imaging (thoracic and abdominal CT scan) showed a right-sided diaphragmatic hernia that was contained the liver and right colon. The patient underwent right posterior thoracotomy at first, so the 5*5 cm diaphragmatic defect was repaired. Due to peritonitis that happened after two days, a midline laparotomy was performed. Finally, it was cleared that the main problem was the obstructed and perforated descending colon mass that was presented with Bockdalek hernia. Unfortunately, she died.Conclusion It is important to determine the reason for the presentation of the symptomatic diaphragmatic hernia in adult patients. It should be considered that an increase of intra-abdominal pressure like the presence of obstructed colon mass can cause it.

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