Distinct characteristics of the substrate binding between highly homologous catalase-related allene oxide synthase and hydroperoxide lyase

2019 ◽  
Vol 676 ◽  
pp. 108126
Author(s):  
Tarvi Teder ◽  
Nigulas Samel ◽  
Helike Lõhelaid
Keyword(s):  
Substrate Binding ◽  
Hydroperoxide Lyase ◽  
Allene Oxide ◽  
Allene Oxide Synthase ◽  
Oxide Synthase

Allene oxide synthase and hydroperoxide lyase product accumulation in Artemisia species

Plant Science ◽  
2005 ◽  
Vol 169 (1) ◽  
pp. 139-146 ◽  
Author(s):  
Meshack Afitlhile ◽  
Hirotada Fukushige ◽  
Charles McCraken ◽  
David Hildebrand
Keyword(s):  
Hydroperoxide Lyase ◽  
Allene Oxide ◽  
Allene Oxide Synthase ◽  
Artemisia Species ◽  
Oxide Synthase ◽  
Product Accumulation

scholarly journals ALLENE OXIDE SYNTHASE and HYDROPEROXIDE LYASE, Two Non-Canonical Cytochrome P450s in Arabidopsis thaliana and Their Different Roles in Plant Defense

2019 ◽  
Vol 20 (12) ◽  
pp. 3064 ◽  
Author(s):  
Sachin Rustgi ◽  
Armin Springer ◽  
ChulHee Kang ◽  
Diter von Wettstein ◽  
Christiane Reinbothe ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Plant Defense ◽  
Metabolic Regulation ◽  
Insect Pests ◽  
Green Leaf Volatiles ◽  
Hydroperoxide Lyase ◽  
Allene Oxide ◽  
Allene Oxide Synthase ◽  
Cytochrome P450 Enzymes ◽  
Oxide Synthase

The channeling of metabolites is an essential step of metabolic regulation in all living organisms. Multifunctional enzymes with defined domains for metabolite compartmentalization are rare, but in many cases, larger assemblies forming multimeric protein complexes operate in defined metabolic shunts. In Arabidopsis thaliana, a multimeric complex was discovered that contains a 13-lipoxygenase and allene oxide synthase (AOS) as well as allene oxide cyclase. All three plant enzymes are localized in chloroplasts, contributing to the biosynthesis of jasmonic acid (JA). JA and its derivatives act as ubiquitous plant defense regulators in responses to both biotic and abiotic stresses. AOS belongs to the superfamily of cytochrome P450 enzymes and is named CYP74A. Another CYP450 in chloroplasts, hydroperoxide lyase (HPL, CYP74B), competes with AOS for the common substrate. The products of the HPL reaction are green leaf volatiles that are involved in the deterrence of insect pests. Both enzymes represent non-canonical CYP450 family members, as they do not depend on O2 and NADPH-dependent CYP450 reductase activities. AOS and HPL activities are crucial for plants to respond to different biotic foes. In this mini-review, we aim to summarize how plants make use of the LOX2–AOS–AOC2 complex in chloroplasts to boost JA biosynthesis over volatile production and how this situation may change in plant communities during mass ingestion by insect pests.

Regulation of oxylipin synthesis

2000 ◽  
Vol 28 (6) ◽  
pp. 847-849 ◽  
Author(s):  
D. F. Hildebrand ◽  
M. Afitlhile ◽  
H. Fukushige
Keyword(s):  
Fatty Acids ◽  
Plant Species ◽  
Citrullus Lanatus ◽  
Product Formation ◽  
Hydroperoxide Lyase ◽  
Allene Oxide ◽  
Allene Oxide Synthase ◽  
Esterified Fatty Acids ◽  
Oxide Synthase ◽  
Fatty Acid Hydroperoxides

Two very common groups of oxylipins formed in plants involve the conversion of fatty acid hydroperoxides, such as hydroperoxy-octadecatrienoic acid, into further metabolites by allene oxide synthase and hydroperoxide lyase. Both of these oxylipin branch pathways appear to be ubiquitous or nearly so in plants, but the relative activities of these two branches vary among plant species. In most plants examined, including Arabidopsis product formation from either of these pathways is minimal until elicited by wounding or some other means, upon which products from both pathways, such as jasmonic acid and C6 aldehydes and alcohols, can increase by orders of magnitude. In some plant species such as Artemisia and Jasminum spp. oxylipin product formation is heavily skewed towards allene oxide synthase products. Others such as watermelon (Citrullus lanatus) produce 10-fold higher amounts or more of hydroperoxide lyase than allene oxide synthase products. Arabidopsis and tobacco are intermediate between these extremes. Artemisia and Jasminum are also unusual in that they do not require wounding or other types of induction for high oxylipin product formation. Release of non-esterified fatty acids appears to be correlated with oxylipin formation, but phospholipase A2 appears not to be involved with oxylipin production, at least in the case of Artemisia leaves.

Oxylipin biosynthesis in spikemoss Selaginella moellendorffii: Identification of allene oxide synthase (CYP74L2) and hydroperoxide lyase (CYP74L1)

2022 ◽  
Vol 195 ◽  
pp. 113051
Author(s):  
Yana Y. Toporkova ◽  
Elena K. Askarova ◽  
Svetlana S. Gorina ◽  
Lucia S. Mukhtarova ◽  
Alexander N. Grechkin
Keyword(s):  
Hydroperoxide Lyase ◽  
Allene Oxide ◽  
Allene Oxide Synthase ◽  
Selaginella Moellendorffii ◽  
Oxide Synthase

Determinants governing the CYP74 catalysis: Conversion of allene oxide synthase into hydroperoxide lyase by site-directed mutagenesis

FEBS Letters ◽  
2008 ◽  
Vol 582 (23-24) ◽  
pp. 3423-3428 ◽  
Author(s):  
Yana Y. Toporkova ◽  
Yuri V. Gogolev ◽  
Lucia S. Mukhtarova ◽  
Alexander N. Grechkin
Keyword(s):  
Site Directed Mutagenesis ◽  
Hydroperoxide Lyase ◽  
Directed Mutagenesis ◽  
Allene Oxide ◽  
Allene Oxide Synthase ◽  
Oxide Synthase

scholarly journals Specific Adduction of Plant Lipid Transfer Protein by an Allene Oxide Generated by 9-Lipoxygenase and Allene Oxide Synthase

2006 ◽  
Vol 281 (51) ◽  
pp. 38981-38988 ◽  
Author(s):  
Bénédicte Bakan ◽  
Mats Hamberg ◽  
Ludivine Perrocheau ◽  
Daniel Maume ◽  
Hélène Rogniaux ◽  
...  
Keyword(s):  
Lipid Transfer Protein ◽  
Allene Oxide ◽  
Allene Oxide Synthase ◽  
Lipid Transfer ◽  
Plant Lipid ◽  
Transfer Protein ◽  
Oxide Synthase
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