Low serum vitamin D, statin associated muscle symptoms, vitamin D supplementation

Abstract Background Vitamin D is a critical factor in bone remodelling, calcium absorption and may promote anti-inflammatory cytokines in the gut. Inflammatory bowel disease (IBD) is associated with a reduction in serum Vitamin D levels and a chronic inflammatory state, both of which are strong risk factors for bone density loss affecting IBD patients. Despite European and North American IBD maintenance guidelines for Vitamin D monitoring and bone density scans, there are limited North American investigations into factors influencing serum Vitamin D levels in the IBD patient population specifically. Aims We investigated whether patient demographics, disease severity indexes and/or inflammatory markers were linked to low serum Vitamin D levels in our IBD patients. We also established the extent of Vitamin D serum deficiencies and supplementation rates in our IBD patients. Methods A retrospective chart review of a single clinician’s practice at London Health Science Centre, Victoria Hospital, over the past 20 months, was performed to: 1) assess the frequency of low serum 25-OH Vitamin D (25-OH D) in the IBD patient population and 2) determine whether patient disease severity was linked to lower 25-OH D levels. A multivariate regression analysis was performed assessing Crohn’s Disease (CD) or Ulcerative Colitis (UC) patient factors: age, sex, disease duration, seasonality, current pharmacologic treatments, past surgeries, CD Activity Index, UC Mayo score, C-reactive protein, and fecal calprotectin (Fcal) level. Results 175 IBD patients had at least one 25-OH D measurement with 71 patients actively on Vitamin D therapy. Of UC and CD patients who were not on Vitamin D therapy, 63% (17/27) and 79% (61/77) were 25-OH D deficient, respectively. 25-OH D levels in the CD population was associated with Vitamin D supplementation (regression coefficient [RC] 23.99, 95% confidence interval [CI] 14.54 to 33.45), summer season ([RC] 9.90, [CI] 0.56 to 19.24), and past bowel resection ([RC] -10.61, [CI] -20.48 to -0.76). 25-OH D levels in the UC population was associated with Vitamin D supplementation (regression coefficient [RC] 47.23, 95% confidence interval [CI] 27.62 to 66.83), and Mayo severity scores ([RC] -23.01, [CI] -41.82 to -4.20). Fcal (78 patients) was inversely associated with 25-OH D levels but the trend was not significant. Conclusions Overall, 25-OH D levels were lower in both the UC and CD patient populations relative to the already deficient Canadian population. However, IBD patients are responsive to Vitamin D supplementation. Tools with more objective evidence of disease severity such as UC Mayo score and fcal should be prioritized for identifying the IBD population requiring supplementation. Funding Agencies None

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Impact of oral vitamin D supplementation on the ocular surface in people with dry eye and/or low serum vitamin D

Contact Lens and Anterior Eye ◽

10.1016/j.clae.2017.09.007 ◽

2018 ◽

Vol 41 (1) ◽

pp. 69-76 ◽

Cited By ~ 13

Author(s):

Chih-Huang Yang ◽

Julie Albietz ◽

Damien G. Harkin ◽

Michael G. Kimlin ◽

Katrina L. Schmid

Keyword(s):

Vitamin D ◽

Dry Eye ◽

Ocular Surface ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Oral Vitamin ◽

Serum Vitamin D ◽

Low Serum

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Impact of Vitamin D Supplementation on Dry Eye in People with Low Serum Vitamin D

The Egyptian Journal of Hospital Medicine ◽

10.21608/ejhm.2021.180343 ◽

2021 ◽

Vol 84 (1) ◽

pp. 2008-2013

Author(s):

Saber Hamed El Said ◽

Ahmed Ibrahim Basiony ◽

Manar Mohammed Amin ◽

Shaimaa Kamal El-deen

Keyword(s):

Vitamin D ◽

Dry Eye ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Serum Vitamin D ◽

Low Serum

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Retrospective evaluation of the serum level of Vitamin D among COVID-19 patients in Al Madinah, Saudi Arabia

Biochemistry and Biotechnology Research ◽

10.30918/bbr.91.21.018 ◽

2021 ◽

Vol 9 (1) ◽

pp. 8-13

Author(s):

Sultan Siaf Al-Harbi ◽

◽

Yasmine Amaier Al-Harbi ◽

Amal Ezzat Abdellatif ◽

Ziab Zakey Al-Ahmadey ◽

...

Keyword(s):

Vitamin D ◽

Serum Level ◽

Prognostic Significance ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Severe Form ◽

Conclusive Evidence ◽

P Value ◽

Serum Vitamin D ◽

Low Serum

Coronavirus disease (COVID-19) is a new viral illness that affects not only the respiratory system but also leads to multiorgan involvement. Till now, no curative treatment is available; prevention is the only way to reduce the number of infected cases. Low serum level of vitamin D has been implicated in increased susceptibility to coronavirus infection and disease severity. However, there is no conclusive evidence as regards the role of vitamin D in COVID-19 infection and outcome. This study aimed to evaluate the serum level of Vit D in patients with COVID-19 and highlights its prognostic significance. A total of 109 COVID-19 patients' medical records were selected and retrospectively analyzed from Ohoud Hospital in Medina. Data collection was done in the period between 1/4/2020 and 22/2/2021 followed by statistical analysis. The median age for COVID-19 patients was 54 years old. The level of Vit-D was low in patients with COVID-19 with a median of 15.2 ng/ml. Serum ferritin was high in all COVID-19 patients with a median of 720.9 ng/ml. There was a significantly higher rate of developing severe forms of COVID-19 in males compared to females, P-value < 0.001. Serum vitamin D level was significantly lower in patients with COVID-19 compared to control with P-value < 0.001. More reduction in Vit-D level was detected in the severe form of COVID-19 (P-value 0.042). There were significantly lower levels of vitamin D and higher levels of ferritin in the server covid-19 cases, P-values of 0.018 and 0.001, respectively. Low serum Vitamin-D level was significantly associated with a higher risk of COVID-19 infection and a more severe form of the disease that may end by death. Vitamin D supplementation will provide a sufficient serum level of the vitamin that can prevent infection and or minimize COVID-19 severity. Keywords: COVID-19, vitamin D deficiency.

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Evaluation of the hormonal and biochemical changes in obese and non-obese PCOS Iraqi women before and after vitamin D supplementation

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v9i3.2 ◽

2019 ◽

Vol 9 (o3) ◽

Author(s):

Suaad Muhssen Ghazi ◽

Fatin Shallal Farhan

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Follicular Development ◽

High Body Mass Index ◽

Vitamin D Supplementation ◽

The Body ◽

Obese People ◽

Serum Vitamin D ◽

Before And After ◽

Granulose Cells

Vitamin D deficiency is common in women with polycystic ovarian syndrome. Vitamin D plays an important physiologic role in reproductive functions of ovarian follicular development and luteinization through altering anti-müllerian hormone signaling, follicular stimulating hormone activity and progesterone production in human granulose cells. Vitamin D is precipitated in adipose fat tissues, making it notable to be used for the body as a result; obese people with high body mass index are already highly expected to have low levels of serum vitamin D.

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Using genetic variants to evaluate the causal effect of serum vitamin D concentration on COVID-19 susceptibility, severity and hospitalization traits: a Mendelian randomization study

Journal of Translational Medicine ◽

10.1186/s12967-021-02973-5 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Zhiyong Cui ◽

Yun Tian

Keyword(s):

Vitamin D ◽

Fixed Effects ◽

Mendelian Randomization ◽

Causal Effect ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Sensitivity Analyses ◽

Global Test ◽

Serum Vitamin D

Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has struck globally and is exerting a devastating toll on humans. The pandemic has led to calls for widespread vitamin D supplementation in public. However, evidence supporting the role of vitamin D in the COVID-19 pandemic remains controversial. Methods We performed a two-sample Mendelian randomization (MR) analysis to analyze the causal effect of the 25-hydroxyvitamin D [25(OH)D] concentration on COVID-19 susceptibility, severity and hospitalization traits by using summary-level GWAS data. The causal associations were estimated with inverse variance weighted (IVW) with fixed effects (IVW-fixed) and random effects (IVW-random), MR-Egger, weighted edian and MR Robust Adjusted Profile Score (MR.RAPS) methods. We further applied the MR Steiger filtering method, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) global test and PhenoScanner tool to check and remove single nucleotide polymorphisms (SNPs) that were horizontally pleiotropic. Results We found no evidence to support the causal associations between the serum 25(OH)D concentration and the risk of COVID-19 susceptibility [IVW-fixed: odds ratio (OR) = 0.9049, 95% confidence interval (CI) 0.8197–0.9988, p = 0.0473], severity (IVW-fixed: OR = 1.0298, 95% CI 0.7699–1.3775, p = 0.8432) and hospitalized traits (IVW-fixed: OR = 1.0713, 95% CI 0.8819–1.3013, p = 0.4878) using outlier removed sets at a Bonferroni-corrected p threshold of 0.0167. Sensitivity analyses did not reveal any sign of horizontal pleiotropy. Conclusions Our MR analysis provided precise evidence that genetically lowered serum 25(OH)D concentrations were not causally associated with COVID-19 susceptibility, severity or hospitalized traits. Our study did not provide evidence assessing the role of vitamin D supplementation during the COVID-19 pandemic. High-quality randomized controlled trials are necessary to explore and define the role of vitamin D supplementation in the prevention and treatment of COVID-19.

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Serum Vitamin D: Correlates of Baseline Concentration and Response to Supplementation in VITAL-DKD

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab693 ◽

2021 ◽

Author(s):

Cora M Best ◽

Leila R Zelnick ◽

Kenneth E Thummel ◽

Simon Hsu ◽

Christine Limonte ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D3 ◽

Parent Compound ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Total Serum ◽

P Value ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

Vitamin D3 Supplementation

Abstract Context The effect of daily vitamin D supplementation on the serum concentration of vitamin D (the parent compound) may offer insight into vitamin D disposition. Objective To assess the total serum vitamin D response to vitamin D3 supplementation and whether it varies according to participant characteristics. To compare results with corresponding results for total serum 25-hydroxyvitamin D (25(OH)D), which is used clinically and measured in supplementation trials. Design Exploratory study within a randomized trial. Intervention 2,000 International Units of vitamin D3 per day (or matching placebo). Setting Community-based. Participants 161 adults (mean ± SD age 70 ± 6 years; 66% males) with type 2 diabetes. Main Outcome Measures Changes in total serum vitamin D and total serum 25(OH)D concentrations from baseline to year 2. Results At baseline, there was a positive, nonlinear relation between total serum vitamin D and total serum 25(OH)D concentrations. Adjusted effects of supplementation were a 29.2 (95% CI: 24.3, 34.1) nmol/L increase in serum vitamin D and a 33.4 (95% CI: 27.7, 39.2) nmol/L increase in serum 25(OH)D. Among those with baseline 25(OH)D < 50 compared with ≥ 50 nmol/L, the serum vitamin D response to supplementation was attenuated (15.7 vs 31.2 nmol/L; interaction p-value = 0.02), whereas the serum 25(OH)D response was augmented (47.9 vs 30.7 nmol/L; interaction p-value = 0.05). Conclusions Vitamin D3 supplementation increases total serum vitamin D and 25(OH)D concentrations with variation according to baseline 25(OH)D, which suggests that 25-hydroxylation of vitamin D3 is more efficient when serum 25(OH)D concentration is low.

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Association Between cardiometabolic risk factor and responsiveness to vitamin D supplementation: A New Approach using Artificial Neural Network analysis

10.21203/rs.3.rs-76964/v1 ◽

2020 ◽

Author(s):

Elahe Allahyari ◽

Parichehr Hanachi ◽

Seyed Jamal Mirmoosavi ◽

Gordon A. Ferns ◽

Afsane Bahrami ◽

...

Keyword(s):

Vitamin D ◽

Risk Factor ◽

Cardiometabolic Risk ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Cardiometabolic Risk Factor ◽

Baseline Serum ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Artificial Neural

Abstract BackgroundAccumulating data have highlighted the prominence of supplementation as an effective approach for vitamin D deficiency. But individuals vary in their response to vitamin D supplementation. In this study, the effect of cardiometabolic risk factors were evaluate on magnitude of response to vitamin D supplementation by using novel statistical analysis, artificial neural networks(ANNs).Methods608 participants aged between 12 to 19 years old were assed in this prospective interventional study. Nine vitamin D capsules containing 50000IU vitamin D/weekly were given to all participants over the 9 week period. The change in serum 25(OH)D level was calculated as the difference between post-supplementation and basal levels. Suitable ANNs model were selected between different algorithms in the hidden and output layers and different numbers of neurons in the hidden layer. Then, the major determinants in predicting response to vitamin D supplementations were identified (Trial registration: IRCT201509047117N7; 2015-11-25; Retrospectively registered)ResultsSigmoid in both hidden and output layers with 4 hidden neurons had acceptable sensitivity, specificity and accuracy area under the ROC curve in our study. Baseline serum vitamin D (30.4%), waist to hip ratio (10.5%), BMI (10.5%), systolic blood pressure (8%), heart rate (6.4%), and waist circumference (6.1%) were the greatest importance in predicting the response in serum vitamin D levels. ConclusionWe provide the first attempt to relate anthropometric specific recommendations to attain serum vitamin D targets. With the exception of cardiometabolic risk factor, the relative importance of other factors and the mechanisms by which these factors may affect the response requires further analysis in future studies.

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Serum Vitamin D Level and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis of Observational Studies and Randomized Control Trials

Hormone and Metabolic Research ◽

10.1055/a-1153-0657 ◽

2020 ◽

Vol 52 (05) ◽

pp. 305-315

Author(s):

Nasim Säidifard ◽

Hadith Tangestani ◽

Kurosh Djafarian ◽

Sakineh Shab-Bidar

Keyword(s):

Vitamin D ◽

Observational Studies ◽

Meta Analysis ◽

Serum Vitamin ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Vitamin D Supplementation ◽

Inverse Association ◽

Serum Vitamin D ◽

Media Thickness

AbstractIt is reported that vitamin D deficiency is associated with carotid intima-media thickness (CIMT). In addition, several randomized clinical trials (RCTs) have studied the influence of vitamin D supplement on CIMT. However, results are inconclusive. This review aimed to systematically explore the potential link of the serum vitamin D level with CIMT pooling together observational studies and RCTs. PubMed and Scopus were searched for studies published until February 13, 2018. The Fisher’s z (SE) correlation coefficient, odds ratio (OR), and mean (SD) of changes in CIMT from baseline were used to perform meta-analysis in observational studies and RCTs, respectively. To pool data, both a fixed-effects model and a random-effects model (in case of heterogeneity) were used. Heterogeneity was assessed using Cochran’s Q and I2 tests. Nineteen observational studies and 3 RCTs met inclusion criteria. The pooled correlation coefficients of 17 observational studies showed [(Fisher’s z=− 0.41, 95% CI: –0.63 to –0.19, p<0.001), I2=96.9%, p < 0.001] a significant inverse association between serum vitamin D and risk of CIMT. Pooling three risk estimates of three studies [(OR = 1.69, 95% CI: 0.74 to 3.86, p=0.209); I2=085.1%, p<0.001)] indicated no significant association between serum vitamin D status and risk of CIMT. Combining data of RCTs showed vitamin D supplementation significantly reduced CIMT [(MD: –0.034, 95% CI: –0.62 to –0.05, p=0.012), I2=16.6%, p = 0.301]. Our findings show that serum vitamin D is inversely associated with CIMT and vitamin D supplementation may reduce CMIT.

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Low Serum Vitamin D is Independently Associated with Acute Ischemic Stroke

Medicine Today ◽

10.3329/medtoday.v30i1.35564 ◽

2018 ◽

Vol 30 (1) ◽

pp. 34-37

Author(s):

Md Mahabubul Islam Majumder ◽

Md Nazmul Hasan Chowdhury ◽

Ashiqur Rahman Khan ◽

Tarek Ahmed ◽

Saleh Ahmed

Keyword(s):

Vitamin D ◽

Ischemic Stroke ◽

Acute Stroke ◽

Acute Ischemic Stroke ◽

Serum Vitamin ◽

Multivariate Logistic Regression Analysis ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Low Serum

Low serum vitamin D levels have been associated with various vascular diseases. Very little is known its association with acute stroke in Bangladeshi population. We therefore sought to assess whether low serum 25- hydroxyvitamin D, a marker of vitamin D status is associated with acute stroke. We performed a prospective study in Comilla Medical Collage, Comilla, from November 2016 to November 2017. All the patients diagnosed as acute ischemic stroke on the basis of CT scan or MRI of brain. Patients were eligible for inclusion if they were admitted with onset of symptoms within 24 hours. Estimation of 25(OH)D level was done at presentation. The patients were stratified by vitamin D status, >30 as vitamin D sufficient, vitamin D 20-20.9 as insufficient and finally vitamin D<20 as deficient. Multivariate logistic regression analysis revealed that out of the desired 7 variables, smoking, hypertension and low serum vitamin D were found independent predictors for acute stroke with ORs being 1.44, 4.23 and 2.39 respectively. Vitamin D deficiency represents an important risk factor for acute stroke and it might play a causal role in the development adverse events associated with stroke.Medicine Today 2018 Vol.30(1): 34-37

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