scholarly journals A role of autophagy in spinocerebellar ataxia—Rare exception or general principle?

Autophagy ◽  
2016 ◽  
Vol 12 (7) ◽  
pp. 1208-1209
Author(s):  
Margit Burmeister ◽  
Jun-Hee Lee ◽  
Brenda A. Schulman ◽  
Zuhal Yapici ◽  
Aslıhan Tolun ◽  
...  
2021 ◽  
Author(s):  
James McGregor ◽  
Abigail Grassler ◽  
Paul I. Jaffe ◽  
Amanda Louise Jacob ◽  
Michael Brainard ◽  
...  

Songbirds and humans share the ability to adaptively modify their vocalizations based on sensory feedback. Prior studies have focused primarily on the role that auditory feedback plays in shaping vocal output throughout life. In contrast, it is unclear whether and how non-auditory information drives vocal plasticity. Here, we first used a reinforcement learning paradigm to establish that non-auditory feedback can drive vocal learning in adult songbirds. We then assessed the role of a songbird basal ganglia-thalamocortical pathway critical to auditory vocal learning in this novel form of vocal plasticity. We found that both this circuit and its dopaminergic inputs are necessary for non-auditory vocal learning, demonstrating that this pathway is not specialized exclusively for auditory-driven vocal learning. The ability of this circuit to use both auditory and non-auditory information to guide vocal learning may reflect a general principle for the neural systems that support vocal plasticity across species.


Author(s):  
John Baker

This chapter traces the history of negligence in tort. The role of fault in the action of trespass vi et armis is somewhat speculative, since the relevant facts were hidden from courts by the plea of Not Guilty. But the concept of inevitable accident seems to be predicated on negligence. Negligence is more visible in actions on the case, though the earliest examples were contractual in essence. The first signs of a distinct tort of negligence, where there was no contract or custom imposing liability, appear in the seventeenth century, and in the next century there emerges a general principle that everyone must take reasonable care not to injure his neighbour. The duty of care was gradually enlarged between the eighteenth century and the present, especially with the removal of obstacles connected with the principle volenti non fit injuria and with the old notion that trespass would not lie for words.


Traffic ◽  
2008 ◽  
Vol 9 (7) ◽  
pp. 1088-1100 ◽  
Author(s):  
Béatrice Marquèze-Pouey ◽  
Nicole Martin-Moutot ◽  
Marie Sakkou-Norton ◽  
Christian Lévêque ◽  
Yong Ji ◽  
...  

2017 ◽  
Vol 42 ◽  
pp. 54-60 ◽  
Author(s):  
Thais Lampert Monte ◽  
Fernanda Santos Pereira ◽  
Estela da Rosa Reckziegel ◽  
Marina Coutinho Augustin ◽  
Lucas Dorídio Locks-Coelho ◽  
...  

2017 ◽  
Vol 112 (3) ◽  
pp. 405a
Author(s):  
Yalan Zhang ◽  
Luis Varela ◽  
Tamas Horvath ◽  
Leonard Kaczmarek

Author(s):  
Qin-Wei Wu ◽  
Josef P. Kapfhammer

Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases which are caused by diverse genetic mutations in a variety of different genes. We have identified RGS8, a regulator of G-protein signaling, as one of the genes which are dysregulated in different mouse models of SCA (e.g., SCA1, SCA2, SCA7, and SCA14). In the moment, little is known about the role of RGS8 for pathogenesis of spinocerebellar ataxia. We have studied the expression of RGS8 in the cerebellum in more detail and show that it is specifically expressed in mouse cerebellar Purkinje cells. In a mouse model of SCA14 with increased PKCγ activity, RGS8 expression was also increased. RGS8 overexpression could partially counteract the negative effects of DHPG-induced mGluR1 signaling for the expansion of Purkinje cell dendrites. Our results suggest that the increased expression of RGS8 is an important mediator of mGluR1 pathway dysregulation in Purkinje cells. These findings provide new insights in the role of RGS8 and mGluR1 signaling in Purkinje cells and for the pathology of SCAs.


Neurology ◽  
2006 ◽  
Vol 67 (4) ◽  
pp. 607-613 ◽  
Author(s):  
M. Wakamiya ◽  
T. Matsuura ◽  
Y. Liu ◽  
G. C. Schuster ◽  
R. Gao ◽  
...  

2019 ◽  
Vol 68 (04) ◽  
pp. 1041-1054
Author(s):  
Neil McDonald

AbstractThis article makes two main propositions about the role of due diligence in international law, in response to recent interest in the topic. First, a legal requirement to exercise due diligence may be a component part of a primary rule of international law, but this can only be determined by referring back to the primary rule in question (eg what degree of fact-finding does treaty provision X require a State party to that treaty to undertake, either explicitly or implicitly, to act consistently with its terms?). In other words, there is no ‘general principle of due diligence’ in international law. Second, States undertake what could be characterised as ‘due diligence’ activity (eg by introducing policy guidance for their officials), some elements of which may be a result of a legal requirement and some of which may not (eg where done solely for policy reasons). Current practice of the United Kingdom and United States is used to illustrate the point. The lack of a distinction between the ‘legal’ and ‘non-legal’ elements of conduct in a given area gives States the flexibility to act without feeling unduly constrained by international law, and at the same time actually promotes compliance with international law and may assist in its development over time. In contrast, pushing for a ‘general principle of due diligence’ in international law is unnecessary, and risks having a chilling effect on this positive legal/policy ‘due diligence’ behaviour by States.


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