P1569ADIPONECTIN IS ASSOCIATED WITH DECLINE IS SKELETAL MUSCLE MASS AND BONE MINERAL CONTENT IN PATIENTS ON HEMODIALYSIS

Abstract Background and Aims Patients on hemodialysis are prone to undernutrition, malnutrition-inflammation-atherosclerosis (MIA) syndrome, and protein-energy wasting (PEW). One of the major adipocytokines adiponectin (ADPN) is involved in anti-arteriosclerotic and anti-inflammatory processes. However, ADPN is implicated in muscle weakness and loss of muscle mass in the elderly in addition to sarcopenia. At the 2019 ERA-EDTA Congress, we announced that total plasma ADPN levels in patients on hemodialysis (HD) showed a significant inverse correlation with BMI, body fat in percentage, mass and estimated skeletal muscle mass, and ADPN may be involved in sarcopenia in patients on HD. Herein, we investigated the association of ADPN level with sarcopenia in patients on HD using a method different from the one used in our previous study. We examined the relationship between total plasma ADPN level and the rate of change in estimated skeletal muscle mass, bone mineral content, and body fat mass over 5 years after the plasma ADPN measurement. Furthermore, we analyzed whether an elevated ADPN level was predictive of a subsequent decline in these parameters. Method Total plasma ADPN levels were measured using ELISA (Bio Vendor-Laboratorni Medicina a.s., Czech Republic) in 42 male patients on HD (age: 51.1 ± 9.0 years, dialysis vintage: 144.8 ± 99.2 months, BMI: 21.8 ± 3.2, dry BW: 62.0 ± 10.9 kg, dialysis time: 15.6 ± 3.1 hours/week). The estimates of skeletal muscle mass, bone mineral content, and body fat mass were made using multi-frequency bioelectrical impedance analysis (MFBIA) within the same year when total plasma ADPN level were first measured in 2011 as well as in 2016. We then calculated the rates of change in the estimated skeletal muscle mass, bone mineral content, and body fat mass over the 5 years and correlated these parameters with the total plasma ADPN measurements. Results Conclusion Total plasma ADPN levels inversely correlate with larger rates of decrease in estimated skeletal muscle mass and bone mineral content in patients on HD. This suggests that ADPN may play a role in the decline in skeletal muscle mass and bone mineral content over time in patients on HD.

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Effects of PM2.5 on Skeletal Muscle Mass and Body Fat Mass of the Elderly in Taipei, Taiwan

Scientific Reports ◽

10.1038/s41598-019-47576-9 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 3

Author(s):

Chi-Hsien Chen ◽

Li-Ying Huang ◽

Kang-Yun Lee ◽

Chih-Da Wu ◽

Hung-Che Chiang ◽

...

Keyword(s):

Skeletal Muscle ◽

Muscle Mass ◽

Body Fat ◽

Fat Mass ◽

Skeletal Muscle Mass ◽

The Elderly ◽

Body Fat Mass

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Effects of Adolescents’ Lifestyle Habits and Body Composition on Bone Mineral Density

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18116170 ◽

2021 ◽

Vol 18 (11) ◽

pp. 6170

Author(s):

ChangSook Han ◽

HyoKyung Kim ◽

Suhee Kim

Keyword(s):

Bone Mineral Density ◽

Skeletal Muscle ◽

Bone Mass ◽

Muscle Mass ◽

Body Fat ◽

Fat Mass ◽

Skeletal Muscle Mass ◽

Body Fat Mass ◽

Mineral Density ◽

Calcium Supplements

The incidence of osteoporosis is increasing as the population ages, as is the need to manage and prevent it. Adolescence is the period when the fastest development of bone mass takes place. Increasing adolescents’ maximum bone mass and avoiding the risk factors for its loss are effective for preventing osteoporosis. This study investigated the factors influencing adolescents’ bone mineral density (BMD). The participants were 126 middle- and high-school students from Gangwon-do; 47.6% (n = 60) were male, with an average age of 15 (range 12–18) years of age. It was found that age, carbonated beverages, snacks, and calcium supplements were variables that showed significant differences in adolescents’ BMD. Additionally, through correlation analysis, it was found that height, weight, body mass index (BMI), body water, protein, minerals, body fat mass, and skeletal muscle mass were correlated with BMD. Multiple regression analysis identified age, calcium supplements, BMI, body fat mass, and skeletal muscle mass as BMD-associated factors. These results show that adolescents’ BMD is higher with lower body fat mass, higher BMI and skeletal muscle mass, and a higher intake of calcium supplements.

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EFFECTS OF A 6-WEEK CONTROLED EXERCISE PROGRAM AND SEMI-CONTROLED DIET ON BODY FAT AND SKELETAL MUSCLE MASS IN ADULTS

Human Sport Medicine ◽

10.14529/hsm190101 ◽

2019 ◽

Vol 19 (1) ◽

pp. 7-14 ◽

Cited By ~ 2

Author(s):

F Kukić ◽

N Todorović ◽

N Cvijanović

Keyword(s):

Skeletal Muscle ◽

Muscle Mass ◽

Body Mass ◽

Body Fat ◽

Fat Mass ◽

Skeletal Muscle Mass ◽

Body Height ◽

Exercise Program ◽

Body Fat Mass ◽

Dietary Regimen

Aim. To investigate the effects of a 6-week of controlled exercise program followed by a semi-controlled dietary regimen on indicators of body fat mass (BF) and skeletal muscle mass (SMM) of adults. Materials and methods. The sample consisted of 28 particpants with the main characteristics of the sample being: age = 29.70 ± 8.35 years, body height (BH) = 177.35 ± 9.36 cm, and body mass (BM) = 105.20 ± 27.06 kg. Body composition parameters, BM, body fat mass (BF), trunk fat (TF), skeletal muscle mass (SMM), percent of body fat (PBF), percent of skeletal muscle mass (PSMM), body mass index (BMI), and index of hypokinesia (IH) were collected before and after six weeks of exercise program and semi-controlled diet regimen. A Paired sample T-test and effect size (ES) were used to determine the effects and their magnitude of the treatment applied. Results. A 6-week treatment significantly affected investigated variables, wherein BF (–6.75 kg, p < 0.001), TF (–3.28 kg, p < 0.001), and SMM (–0.91 kg, p = 0.003) tissue decreased in a different degree, leading to a small but highly significant increase in PSMM (2.60 %, p < 0.001). A decrease in BF and SMM resulted in a significant reduction in BMI, while IH decreased in a smaller degree than BMI because PBF and PSMM changed inversely. Conclusion. Six weeks of a controlled exercise program 3 times/week and semi-controlled diet is an effective approach to the reduction of BM, BF, and TF and to increasing the movement potential by changing the proportions of PBF and PSMM.

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Greater lean tissue and skeletal muscle mass are associated with higher bone mineral content in children

Nutrition & Metabolism ◽

10.1186/1743-7075-7-41 ◽

2010 ◽

Vol 7 (1) ◽

pp. 41 ◽

Cited By ~ 11

Author(s):

Karen B Dorsey ◽

John C Thornton ◽

Steven B Heymsfield ◽

Dympna Gallagher

Keyword(s):

Skeletal Muscle ◽

Bone Mineral Content ◽

Muscle Mass ◽

Bone Mineral ◽

Skeletal Muscle Mass ◽

Mineral Content ◽

Lean Tissue

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The Relationship between Serum Insulin-Like Growth Factor-1 Levels and Body Composition Changes after Sleeve Gastrectomy

Obesity Facts ◽

10.1159/000519610 ◽

2021 ◽

pp. 1-9

Author(s):

Masahiro Ohira ◽

Yasuhiro Watanabe ◽

Takashi Yamaguchi ◽

Hiroki Onda ◽

Shuhei Yamaoka ◽

...

Keyword(s):

Skeletal Muscle ◽

Body Composition ◽

Muscle Mass ◽

Body Fat ◽

Fat Mass ◽

Skeletal Muscle Mass ◽

Body Fat Mass ◽

Preoperative Serum ◽

The Relationship ◽

Composition Changes

Introduction: We previously reported that preoperative serum insulin-like growth factor-1 (IGF-1) is a predictor of total weight loss percentage (%TWL) after laparoscopic sleeve gastrectomy (LSG). IGF-1 may suppress muscle loss after surgery. IGF-1 almost accurately reflects the growth hormone (GH) secretion status, and GH has lipolytic effects. Therefore, IGF-1 may influence both the maintenance of skeletal muscle and the reduction of adipose tissue after LSG. The identification of the relationship between preoperative serum IGF-1 and body composition changes after LSG can help in understanding the pathophysiology of obesity. Methods: We retrospectively reviewed 72 patients with obesity who underwent LSG and were followed up for 12 months. We analyzed the relationship between preoperative serum IGF-1 levels and body composition changes after LSG. A multiple regression model was used. Results: LSG led to a significant reduction in body weight. Both body fat mass and skeletal muscle mass decreased after LSG. Preoperative serum IGF-1 levels significantly correlated with %TWL, changes in skeletal muscle mass, and body fat mass after LSG. The multiple regression model showed that preoperative serum IGF-1 levels were related to decreased body fat mass and maintaining skeletal muscle mass after LSG. Discussion/Conclusion: Preoperative IGF-1 measurement helps predict not only successful weight loss but also decreases body fat mass and maintains skeletal muscle mass after LSG.

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