scholarly journals Is Vitamin D Insufficiency Associated with Mortality of Critically Ill Patients?

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Gulbin Aygencel ◽  
Melda Turkoglu ◽  
Ayse Fitnat Tuncel ◽  
Burcu Arslan Candır ◽  
Yelda Deligoz Bildacı ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Independent Risk Factor ◽  
Vitamin D Insufficiency ◽  
University Hospital ◽  
Median Serum ◽  
Vitamin D Levels ◽  
Sufficient Vitamin

Objective. To evaluate the vitamin D status of our critically ill patients and its relevance to mortality.Patients and Methods. We performed a prospective observational study in the medical intensive care unit of a university hospital between October 2009 and March 2011. Vitamin D levels were measured and insufficiency was defined as <20 ng/mL.Results. Two hundred and one patients were included in the study. The median age was 66 (56–77) and the majority of patients were male (56%). The median serum level of vitamin D was 14,9 ng/mL and 139 (69%) patients were vitamin D insufficient on admission. While we grouped the ICU patients as vitamin D insufficient and sufficient, vitamin D insufficient patients had more severe acute diseases and worse laboratory values on admission. These patients had more morbidities and were exposed to more invasive therapies during stay. The mortality rate was significantly higher in the vitamin D insufficient group compared to the vitamin D sufficient group (43% versus 26%,P=0,027). However, logistic regression analysis demonstrated that vitamin D insufficiency was not an independent risk factor for mortality.Conclusion. Vitamin D insufficiency is common in our critically ill patients (69%), but it is not an independent risk factor for mortality.

scholarly journals Association Between Low Serum Vitamin D Levels and Sepsis: A Single-Center Study in Tehran, Iran

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Masume Bayat ◽  
Latif Gachkar ◽  
Mahya Zahirnia ◽  
Fahimeh Hadavand
Keyword(s):  
Vitamin D ◽  
Severe Sepsis ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Plasma Concentrations ◽  
Serum Vitamin ◽  
Vitamin D Insufficiency ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: Vitamin D insufficiency is common in critically ill patients. It is hypothesized that vitamin D deficiency would be associated with sepsis in the critically ill. Thus, the present study aimed to investigate the association between vitamin D and sepsis severity. Method: In this cross-sectional study, patients with sepsis referring to a university hospital in Tehran, Iran, from February 2018 to March 2019 were included. Plasma concentrations of vitamin D in critically ill subjects admitted were assessed. Data were analyzed using SPSS version 20.0. P-values less than 0.05 were considered statistically significant. Results: Among the investigated patients, the mean serum level of vitamin D3 was 19.03 ± 13.08 ng/mL. The prevalence of vitamin D insufficiency in critically ill subjects with sepsis was 100% (150/150). Only sex (P = 0.01) indicated a significant association with vitamin D. Patients suffering from severe sepsis had lower levels of vitamin D compared to the patients with non-severe sepsis (P = 0.07). Conclusions: The present study showed that all critically ill patients studied had vitamin D insufficiency. In line with the biological evidence, the present study suggests that vitamin D deficiency may predispose patients to sepsis. Further studies are needed to establish the causes and mechanisms underlying these interpretations.

Depression as an Independent Risk Factor for Mortality in Critically Ill Patients

2015 ◽  
Vol 77 (2) ◽  
pp. 106-113 ◽  
Author(s):  
Marlene Wewalka ◽  
Joanna Warszawska ◽  
Volker Strunz ◽  
Reinhard Kitzberger ◽  
Ulrike Holzinger ◽  
...  
Keyword(s):  
Risk Factor ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Independent Risk Factor

scholarly journals Hypovitaminosis D Is A Risk Factor for Posterior Chain Muscular Injury in NCAA Division I Track And Field Athletes

2019 ◽  
Vol 7 (7_suppl5) ◽  
pp. 2325967119S0040
Author(s):  
Adam Lindsay ◽  
Omid Jalali ◽  
Shane Korber ◽  
Russ Romano ◽  
James E. Tibone ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Ncaa Division I ◽  
Independent Risk Factor ◽  
Hypovitaminosis D ◽  
Track And Field ◽  
Division I ◽  
Muscular Injury ◽  
Vitamin D Levels ◽  
Track Athletes

Objectives: Currently little information is available in evaluating micronutrient requirements in elite athletes. Despite evidence that groups of NCAA athletes may be deficient in Vitamin D, no study to date has examined Vitamin D levels with respect to their predicative values for injuries to the ‘posterior chain’ musculature. The objective of this study was to evaluate the association between hypovitaminosis D and posterior chain injuries in NCAA Division I track and field athletes. Methods: After IRB approval, we evaluated data for men’s and women’s outdoor track and field teams from 2015-2018 at a large NCAA Division I athletics program. Vitamin D levels were drawn during pre-season annual physicals. The cutoff for hypovitaminosis D was set at 40 nmol/L. Demographic and athletic tenure data were recorded and analyzed, and competitive events were grouped into one of four categories: 1) running events, 2) jumping events, 3) throwing events, and 4) multiple event types. Student T tests, chi-squared tests, and multivariate logistic regression were performed. Results: The analysis consisted of 145 (58% female, 42% male) NCAA Division I track athletes. Eighty-five of the 145 athletes had hypovitaminosis D. A full breakdown of athlete characteristics by vitamin D status can be seen in Figure 1 and Table 1. Of the 145 athletes analyzed, 33 (22.7%) suffered a muscular injury to their posterior chain musculature. Multinomial logistic regression identified hypovitaminosis D as an independent risk factor for posterior chain injury (relative risk ratio: 3.23, p=0.016). Age, BMI, and event type were not predictive of a posterior chain injury. Of note, 4 (4.7%) athletes in the hypovitaminosis D group suffered multiple posterior chain injuries, with 2 (2.4%) athletes suffering 2 separate injuries and 2 (2.4%) athletes suffering 3 separate injuries. None of the athletes in the normal Vitamin D group suffered multiple posterior chain injuries. Conclusion: These results demonstrate that pre-season hypovitaminosis D is an independent risk factor for posterior chain muscular injury in NCAA division I track athletes. These data suggest that early detection of hypovitaminosis D may play a critical role in injury prevention for these athletes. [Table: see text]

scholarly journals Vitamin D levels in critically ill patients with acute kidney injury: a protocol for a prospective cohort study (VID-AKI)

BMJ Open ◽  
2017 ◽  
Vol 7 (7) ◽  
pp. e016486 ◽  
Author(s):  
Lynda Katherine Cameron ◽  
Katie Lei ◽  
Samantha Smith ◽  
Nanci Leigh Doyle ◽  
James F Doyle ◽  
...  
Keyword(s):  
Vitamin D ◽  
Acute Kidney Injury ◽  
Cohort Study ◽  
Critically Ill ◽  
Prospective Cohort Study ◽  
Critically Ill Patients ◽  
Prospective Cohort ◽  
Kidney Injury ◽  
Vitamin D Levels

scholarly journals Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection 

2020 ◽  
Author(s):  
Alireza Davoudi ◽  
Narges Najafi ◽  
Mohsen arabi ◽  
Atefe Tayebi ◽  
Roja Nikaeen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Clinical Outcomes ◽  
Underlying Disease ◽  
Vitamin D Insufficiency ◽  
Mazandaran Province ◽  
Vitamin D Levels ◽  
Duration Of Hospitalization ◽  
North Of Iran ◽  
Definition Of ◽  
Sufficient Vitamin

Abstract Background A protective effect of vitamin D against COVID-19 is under investigation. We aimed to analyze the effect of vitamin D sufficiency on clinical outcomes of patients with COVID-19 infection. Methods In this retrospective study we analyzed the vitamin D levels of COVID-19 patients who were admitted to Razi Hospital (an infectious disease referral center in Mazandaran province in north of Iran) from February to March 2020. Overall, a cutoff point of 30 ng/mL was used for the definition of vitamin D sufficiency. Results 153 patients were analyzed in this study who had laboratory documentation of a 25(OH) D level at the time of hospitalization. In total, 62.7% (n-=96) of the patients had a 25(OH) D level of less than 30 ng/mL and 37.25% (n = 57) had a 25(OH) D level of more than 30 ng/mL. In total, 49% (n = 75) of the patients suffered from at least one underlying disease. Vitamin D sufficiency was not associated with a statistically significant lower risk of adverse clinical outcomes of COVID-19 such as duration of hospitalization, lung involvement, intensive care unit (ICU) admission, invasive and non-invasive ventilation, the severity of disease or death. Conclusions Sufficient vitamin D levels were not found to be protective against adverse clinical outcomes in patients infected with COVID-19.

scholarly journals Up to 40% of COVID-19 Critically Ill Patients Have Vitamin D Deficiency

2020 ◽  
Author(s):  
Teresa-Maria Tomasa-Irriguible ◽  
Lara Bielsa-Berrocal
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Statistical Significance ◽  
Vitamin D Status ◽  
Reactive Protein ◽  
Vitamin D Levels ◽  
Polymerase Chain ◽  
Potential Strategy

Background: Coronavirus disease (COVID-19) has caused more than 745,000 deaths worldwide. Vitamin D has been identified as a potential strategy to prevent or treat this disease. The purpose of the study was to measure vitamin D at hospital admission of COVID-19; Methods: We included critically ill patients with the polymerase chain reaction positive test for COVID-19, from March to April, 2020. Statistical significance was defined as P &amp;lt; .05. All tests were 2-tailed; Results: A total of 35 patients (median age, 60 years; 26 [74.3%] male) were included. Vitamin D levels were categorized as deficient for 14 participants (40%). Vitamin D deficiency was associated with vitamin A (P= 0.003) and Zinc (P= 0.019) deficiency and lower levels of albumin (P= 0.026) and prealbumin (P= 0.009). Overall, none of the studied variables were associated with vitamin D status: mortality, intensive care unit (ICU) or hospital stay, necessity of vasoactive agents, intubation, prone position, C reactive protein (CRP), Dimer-D, Interleukin 6 levels (IL-6), ferritin levels, or bacterial superinfection; Conclusions: In this single-center, retrospective cohort study, deficient vitamin D status was found in 40% in COVID-19 critically ill patients. However, deficient vitamin D status was not associated with inflammation or outcome.

scholarly journals New-onset atrial fibrillation in critically ill patients with coronavirus disease 2019 (COVID-19)

2021 ◽  
Author(s):  
BİŞAR ERGÜN ◽  
BEGUM ERGAN ◽  
Melih Kaan SÖZMEN ◽  
Mehmet Nuri YAKAR ◽  
Murat KÜÇÜK ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Intensive Care Unit ◽  
Risk Factor ◽  
Intensive Care ◽  
Hospital Mortality ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Independent Risk Factor ◽  
Onset Atrial Fibrillation ◽  
New Onset

Abstract Objectives: To determine the incidence, risk factors, and outcomes of new-onset atrial fibrillation (NOAF) in a cohort of critically ill patients with coronavirus disease 2019 (COVID-19). Methods: We conducted a retrospective study on patients admitted to the intensive care unit (ICU) with a diagnosis of COVID-19. NOAF was defined as atrial fibrillation that was detected after diagnosis of COVID-19 without a prior history. The primary outcome of the study was the effect of NOAF on mortality in critically ill COVID-19 patients. Results: We enrolled 248 eligible patients. NOAF incidence was 14.9% (n=37), and 78% of patients (n=29) were men in NOAF positive group. Median age of the NOAF group was 79.0 (interquartile range, 71.5-84.0). Hospital mortality was higher in the NOAF group (87% vs 67%, respectively, p=0.019). However, in multivariate analysis, NOAF was not an independent risk factor for hospital mortality (OR 1.42, 95% CI 0.40–5.09, p=0.582) Conclusions: The incidence of NOAF was 14.9% in critically ill COVID-19 patients. Hospital mortality was higher in the NOAF group. However, NOAF was not an independent risk factor for hospital mortality in patients with COVID-19. Keywords: Atrial fibrillation, critical care, intensive care unit, COVID-19, mortality, hospital mortality

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