scholarly journals Possible Role of Hyperinsulinemia and Insulin Resistance in Lower Vitamin D Levels in Overweight and Obese Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Giovanni De Pergola ◽  
Alessandro Nitti ◽  
Nicola Bartolomeo ◽  
Antonella Gesuita ◽  
Vito Angelo Giagulli ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Waist Circumference ◽  
Hdl Cholesterol ◽  
Significant Negative Correlation ◽  
Model Assessment ◽  
Obese Patients ◽  
Fasting Insulin ◽  
Vitamin D Levels ◽  
Independent Association

A cohort of 66 healthy overweight and obese patients, 53 women and 13 men were examined. Waist circumference and fasting 25(OH)D, insulin, glucose, lipid (cholesterol, HDL cholesterol, and triglyceride), C-reactive protein (CRP), and complement 3 (C3), and 4 (C4) serum concentrations were measured. Insulin resistance was assessed by the homeostasis model assessment (HOMAIR).Results.25(OH)D levels showed a significant negative correlation with BMI (P<0.01), waist circumference (P<0.05), fasting insulin (P<0.01), HOMAIR(P<0.01), triglycerides (P<0.01), CRP (P<0.01), C3(P<0.05), and C4(P<0.05). Multiple regression analyses were performed with 25(OH)D as the dependent variable and BMI (or waist circumferences), fasting insulin (or HOMAIR), triglycerides, and CRP (or C3or C4) as independent variables. Only insulin or HOMAIRmaintained a significant independent association with 25(OH)D levels, whereas vitamin D did not maintain a significant independent association with CRP or C3or C4concentrations.Conclusions.The present study, performed in overweight and obese subjects, shows that 25(OH)D levels are negatively associated with inflammatory parameters such as CRP and C3and C4levels, but not independently of BMI, body fat distribution, insulin levels, or insulin resistance. Our results suggest that hyperinsulinemia and/or insulin resistance are directly responsible for decrease of 25(OH)D levels in obesity.

scholarly journals Correlation of Serum Vitamin D and Metabolic Disturbances in Polycystic Ovarian Syndrome

2021 ◽  
Vol 4 (1) ◽  
pp. 64-71
Author(s):  
Shasya Aniza Santoso ◽  
◽  
Tita Husnitawati Madjid ◽  
Anita Rachmawati
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Fasting Blood Glucose ◽  
Serum Vitamin ◽  
Metabolic Disturbances ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Objective: This study was aimed to determine the correlation between vitamin D and insulin resistance in women with PCOS. Method: This study was correlational analytic with cross-sectional approach to 34 women diagnosed with PCOS based on ultrasonography. Waist circumference and fasting blood glucose (FBG) represented insulin resistance. Women with hormonal therapy and vitamin D supplementation were not included to this study. This study used consecutive sampling method. Result: The average of age was 25.6±6.1 years old. Waist circumference and fasting blood glucose (FBG) represented insulin resistance. The average of waist circumference and FBG were 87.6±12.4 cm and 86.2±27.9 mg/dl, respectively. The mean of vitamin D levels was 11,5±3,6 ng/ml. According to Spearman’s correlation, vitamin D levels were weak negative correlated with waist circumference (r=-0.2; p>0.05) and FBG (r= -0,1; p>0,05), it statistically was not significant. Conclusion: There is weak negative correlation between vitamin D and metabolic syndrome in PCOS patients.

Vitamin D status and its relation to insulin resistance in a Mexican pediatric population

2020 ◽  
Vol 33 (4) ◽  
pp. 481-486
Author(s):  
Yunue Flores Ruelas ◽  
Mario Del Toro Equihua ◽  
Norma Alejandra Jiménez Solís ◽  
Luz Margarita Baltazar Rodríguez ◽  
Ivan Delgado Enciso ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Children And Adolescents ◽  
Serum Vitamin ◽  
World Health ◽  
Model Assessment ◽  
Inverse Association ◽  
Insulin Levels ◽  
Vitamin D Levels ◽  
The Mean

AbstractBackgroundObesity in children and adolescents has increased alarmingly, placing them at a higher risk for impaired glucose tolerance and type 2 diabetes. The prevalence of vitamin D deficiency has increased as well. Vitamin D is critical for glucose homeostasis and insulin secretion. Studies on adults have reported an inverse association between vitamin D levels and insulin resistance (IR), but the results in children are inconsistent. The aim of our study was to determine the association between IR and serum vitamin D levels in obese Mexican children and adolescents.MethodsA cross-sectional study was performed on 227 children and adolescents between 6 and 19 years of age. Obesity was diagnosed through body mass index (BMI) for age, according to the World Health Organization (WHO) criteria (2007). 25-Hydroxyvitamin D (25[OH]D) was measured using an immunoassay technique and the homeostatic model assessment of insulin resistance (HOMA-IR) was calculated using the Matthews equation. Student’s t-test was carried out.ResultsThe mean serum 25(OH)D level was 35.80 ng/mL, and 55.1% of the subjects had levels classified as sufficient, 33.5% as insufficient, and 11.5% as deficient. The mean level of HOMA-IR was 3.16, and 70% of the subjects were diagnosed with IR. Fasting insulin levels and HOMA-IR were significantly different in adolescents with hypovitaminosis, compared with adolescents in the vitamin D sufficiency group (p = 0.01 and p = 0.03, respectively).ConclusionsThe insulin levels and HOMA-IR were higher in adolescents with hypovitaminosis. The girls presented higher levels of insulin and HOMA-IR than the boys.

scholarly journals Plasma vitamin D levels and risk of metabolic syndrome in Canadians

2011 ◽  
Vol 34 (6) ◽  
pp. 377 ◽  
Author(s):  
Darren R Brenner ◽  
Paul Arora ◽  
Bibiana Garcia-Bailo ◽  
Thomas MS Wolever ◽  
Howard Morrison ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Plasma Level ◽  
Linear Models ◽  
Smoking Status ◽  
Plasma Vitamin ◽  
Model Assessment ◽  
Vitamin D Levels ◽  
Metabolic Syndrome Components

Purpose: Vitamin D deficiency has been implicated in susceptibility to the development of metabolic syndrome, obesity and type 2 diabetes mellitus. The present study aimed to quantify the association between vitamin D plasma level, the number of metabolic syndrome components and insulin resistance in Canadians. Methods: Vitamin D plasma level and clinical data were determined from 1,818 subjects from the Canadian Health Measures Survey; a representative health survey of the general population of Canada conducted from 2007 to 2009. The definition of metabolic syndrome was based on the National Cholesterol Education Program, Adult Treatment Panel III criteria. Adjusted general linear models were used to estimate the association between vitamin D level and probability of having metabolic syndrome, as well as the association between plasma vitamin D and insulin resistance (homeostasis model assessment for insulin resistance, or HOMA-IR). Results: The prevalence of metabolic syndrome in the study population was 8.9%. The number of metabolic syndrome components was inversely correlated with plasma vitamin D level (ρ= -0.1, p < 0.0001). Subjects in the highest vitamin D quartile had lower odds ratio of metabolic syndrome compared with their counterparts in the lowest vitamin D quartile (0.50, 95% CI= 0.24-1.06). Increasing plasma vitamin D level (by 10 nmol/L) was inversely associated with HOMA-IR score (β= -0.08, p=0.006) in a model adjusted for physical activity, smoking status, month of interview, age, sex and ethnicity. Conclusion: Vitamin D plasma levels are associated with the occurrence of metabolic syndrome components and insulin resistance among Canadians and are linked to increased level of insulin resistance.

scholarly journals Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Bing Han ◽  
Qin Li ◽  
Ningjian Wang ◽  
Yi Chen ◽  
Chunfang Zhu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Vitamin D Supplementation ◽  
Model Assessment ◽  
Inverse Association ◽  
Vitamin D Levels ◽  
Males And Females

Background. The relationship between vitamin D and insulin resistance is still controversial. Many factors could influence this relationship. In addition, this relationship in different genders was still unclear. Methods. A total of 6597 subjects, including 2813 males and 3784 females, were analyzed. The serum levels of 25(OH)D, fasting blood glucose (FBG), fasting insulin, HbA1c, and other metabolic parameters were tested. The waist circumference (WC), weight, and height were also measured. Questionnaires regarding smoking and drinking were collected from these subjects. Results. Serum 25(OH)D was categorized into quartiles. Increasing 25(OH)D levels were associated with reduced trend of homeostasis model assessment of insulin resistance (HOMA-IR) in both males and females. Pearson’s correlation indicated 25(OH)D level was inversely associated with the HOMA-IR for male subjects (r=−0.055, P=0.028) but not for female subjects (r=−0.005, P=0.798). Age, triglyceride (TG), and low-density lipoprotein (LDL) were associated with the vitamin D levels in males and females. In regression analysis, serum 25(OH)D concentration was significantly associated with HOMA-IR only in overweight males. Conclusion. We found an inverse association between 25(OH)D and HOMA-IR in Chinese overweight males. Vitamin D supplementation might be beneficial in this population. However, further clinical trials are needed to confirm this association.

scholarly journals Ultra-Early and Early Changes in Bile Acids and Insulin after Sleeve Gastrectomy among Obese Patients

Medicina ◽  
2019 ◽  
Vol 55 (12) ◽  
pp. 757
Author(s):  
Adriana Florinela Cӑtoi ◽  
Alina Elena Pârvu ◽  
Aurel Mironiuc ◽  
Horațiu Silaghi ◽  
Ioana Delia Pop ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Sleeve Gastrectomy ◽  
Model Assessment ◽  
Obese Patients ◽  
Fasting Insulin ◽  
Homeostasis Model Assessment ◽  
Insulin Homeostasis ◽  
Obese Subjects ◽  
Time Point

Background and Objective: In obese patients, sleeve gastrectomy (SG) has shown mixed results on bile acid (BA) values. The aim of our study was to examine the potential ultra-early and early changes of the circulating total BA in relation with the changes of insulin resistance (IR) in obese patients submitted to laparoscopic SG. Materials and Methods: Twenty-four obese subjects were investigated for body mass index (BMI), total fasting BA, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and leptin before and at 7 and 30 d after SG. Results: After surgery, mean BMI decreased at the first (p < 0.001) and at the second time point (p < 0.001) relative to baseline. Total fasting BA values did not change significantly at 7 d (p = 0.938) and at 30 d (p = 0.289) after SG. No significant changes were found at 7 d (p = 0.194, p = 0.34) and 30 d (p = 0.329, p = 0.151) after surgery regarding fasting insulin and HOMA-IR, respectively. However, a trend of increased total fasting BA and decreased fasting insulin and HOMA- after laparoscopic SG has been found. Negative correlations between total fasting BA and insulin (r = −0.807, p = 0.009), HOMA-IR (r = −0.855, p = 0.014), and blood glucose (r = −0.761, p = 0.047), respectively, were observed at one month after SG. Conclusion: In conclusion, here, we found a lack of significant changes in total fasting BA, insulin, and HOMA-IR ultra-early and early after SG, which precluded us to consider a possible relation between the variations of BA and IR. However, the presence of the tendency for total fasting BA to increase and for insulin and HOMA-IR to decrease, as well as of the negative correlations one month after laparoscopic SG, suggest that this surgery brings about some changes that point towards the existence, and possibly towards the restoration, at least to some extent, of the link between BA and glucose metabolism.

scholarly journals Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults

2015 ◽  
Vol 172 (3) ◽  
pp. 291-300 ◽  
Author(s):  
Rui Wang ◽  
Jie Hong ◽  
Yanan Cao ◽  
Juan Shi ◽  
Weiqiong Gu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Young Adults ◽  
Insulin Sensitivity ◽  
Hdl Cholesterol ◽  
Circulating Microrna ◽  
Model Assessment ◽  
Obese Patients ◽  
Serum Samples ◽  
Functional Studies ◽  
Control Subjects

ObjectiveMicroRNAs (miRNAs) are involved in the regulation of adiposity, but functional studies have yielded inconclusive results. Examining the associations of circulating miRNAs levels with obesity and insulin sensitivity in humans may lead to improved insights.Design and methodsSerum samples collected from 112 obese and control subjects (50.0% men) were randomly divided and combined into four pools (28 samples in each obese or control pool). The genome-wide circulating miRNA profiles were detected via microarray. Elevated miR-122 was selected and validated in individual serum samples from 123 obese (46.7% men) and 107 control (50.0% men) young adults. Associations between circulating miR-122 levels and parameters related to adiposity, insulin resistance, lipid profiles and hepatic enzymes were further assessed.ResultsThirty-four miRNAs were found to be expressed differently in the sera of obese patients compared with control subjects (P<0.001). Further analyses confirmed that obese patients had 3.07-fold higher circulating miR-122 levels than controls (P<0.001). Serum miR-122 levels were correlated with BMI (r=0.469), alanine aminotransferase (r=0.634), triglycerides (r=0.448), HDL-cholesterol (r=−0.351) and homeostasis model assessment of insulin resistance (r=0.401, allP<0.01). After controlling for confounding factors, miR-122 remained as an independent risk factor for insulin resistance (OR=3.379, 95% CI=1.141–10.007,P=0.028).ConclusionsElevated circulating miR-122 is positively associated with obesity and insulin resistance in young adults. These findings provide a better understanding regarding the role of miRNAs in adiposity and insulin sensitivity.

scholarly journals The influence of puberty on vitamin D status in obese children and the possible relation between vitamin D deficiency and insulin resistance

2015 ◽  
Vol 28 (1-2) ◽  
Author(s):  
Sonsoles Gutiérrez Medina ◽  
Teresa Gavela-Pérez ◽  
María Nieves Domínguez-Garrido ◽  
Elisa Gutiérrez-Moreno ◽  
Adela Rovira ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Standard Deviation Score ◽  
Normal Weight ◽  
Model Assessment ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Prepubertal Children ◽  
Vitamin D Levels

Abstract: Puberty can affect vitamin D levels.The goal of this study was to analyze the relation between vitamin D deficiency and puberty in obese Spanish children, along with the possible interrelation between vitamin D status and degree of insulin resistance.A cross-sectional study was carried out, in which clinical and biochemical data were gathered from 120 obese and 50 normal weight children between January 2011 and January 2013.: Mean vitamin D levels were 19.5 and 31.6 ng/mL in obese pubertal and obese prepubertal children, respectively. About 75% of the obese pubertal subjects and 46% of the obese prepubertal subjects had vitamin D deficiency. Vitamin D levels were significantly lower in pubescent subjects compared with pre-pubescent subjects in summer, fall, and winter. There was no apparent relation between vitamin D levels and homeostasis model assessment index for insulin resistence (expressed in standard deviation score for sex and Tanner stage) in either puberty or pre-puberty.: Puberty may be a risk factor for the vitamin D deficiency commonly found in the obese child population. This deficiency is not associated with higher insulin resistance in obese pubertal children compared with obese prepubertal children.

scholarly journals The relationship between vitamin D and insulin resistance before delivery in advanced maternal age

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Beibei Dong ◽  
Mengmeng Zhi ◽  
Manman Han ◽  
Hao Lin ◽  
Hong Yu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Maternal Age ◽  
Multivariable Analysis ◽  
Advanced Maternal Age ◽  
Model Assessment ◽  
Gynecology And Obstetrics ◽  
Vitamin D Levels

Abstract Background With the widely implementation of universal two-child policy, the number of pregnant women in advanced maternal age (AMA) will increase gradually. We aimed to assess the association of vitamin D levels and insulin resistance (IR) during the late pregnancy in AMA. Methods A total of 80 pregnant women were consecutively enrolled in the cross-sectional study before delivery from the August 2016 to June 2017 at the department of gynecology and obstetrics in the hospital of ZhongDa, affiliated to Southeast University. At delivery, serum 25(OH) D and metabolism parameters including glucose and lipid levels were measured. IR was calculated by the method of homeostasis model assessment 2(HOMA2). Results Pregnant women in AMA with vitamin D deficiency have higher fasting insulin (14.70(8.76–34.65) and 10.89(7.15–16.12), respectively, P = 0.031) and HOMA-IR indices (1.78(1.07–4.14) and 1.30(0.83–1.89), respectively, P = 0.024) than those with vitamin D non-deficiency. Serum 25(OH) D levels were inversely associated with HOMA-IR indices (r = − 0.25, P = 0.025). In multivariable analysis for adjusting confounder factors, vitamin D non-deficiency was also negatively correlated with HOMA-IR compared to vitamin D deficiency (β = − 1.289, P = 0.026). Conclusions Taken together, our findings suggest that serum 25(OH) D levels were inversely associated with HOMA-IR in AMA. Furthermore, pregnant women in AMA with vitamin D deficiency might have higher HOMA-IR levels than those with vitamin D non-deficiency. Trial registration Chinese Clinical Trial Registry (No. ChiCTR-RRC-16008714). retrospectively registered.

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