Association of Metabolic Health and Central Obesity With the Risk of Thyroid Cancer: Data from the Korean Genome and Epidemiology Study

2021 ◽  
pp. cebp.0255.2021
Author(s):  
Dung Ngoc Nguyen ◽  
Jinhee Kim ◽  
Mi Kyung Kim
Keyword(s):  
Thyroid Cancer ◽  
Central Obesity ◽  
Metabolic Health ◽  
Epidemiology Study ◽  
Cancer Data

Comparison of pediatric and adult primary papillary thyroid cancer cases in the National Cancer Data Base

2015 ◽  
Vol 221 (4) ◽  
pp. e111-e112
Author(s):  
Tate R. Nice ◽  
Sebastian Pasara ◽  
Melanie Goldfarb ◽  
Kenneth W. Gow ◽  
Jed G. Nuchtern ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Data Base ◽  
Papillary Thyroid Cancer ◽  
National Cancer Data Base ◽  
Papillary Thyroid ◽  
Cancer Data

scholarly journals Association between Family Histories of Thyroid Cancer and Thyroid Cancer Incidence: A Cross-Sectional Study Using the Korean Genome and Epidemiology Study Data

Genes ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 1039
Author(s):  
Soo-Hwan Byun ◽  
Chanyang Min ◽  
Hyo-Geun Choi ◽  
Seok-Jin Hong
Keyword(s):  
Thyroid Cancer ◽  
Family History ◽  
Cancer Incidence ◽  
Age At Onset ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Epidemiology Study ◽  
Cross Sectional ◽  
Family Histories ◽  
Thyroid Cancer Incidence

This study assessed the association between thyroid cancer and family history. This cross-sectional study used epidemiological data from the Korean Genome and Epidemiology Study from 2001 to 2013. Among 211,708 participants, 988 were in the thyroid cancer group and 199,588 were in the control group. Trained interviewers questioned the participants to obtain their thyroid cancer history and age at onset. The participants were examined according to their age, sex, monthly household income, obesity, smoking, alcohol consumption, and past medical history. The adjusted odds ratios (95% confidence intervals) for the family histories of fathers, mothers, and siblings were 6.59 (2.05–21.21), 4.76 (2.59–8.74), and 9.53 (6.92–13.11), respectively, and were significant. The results for the subgroup analyses according to sex were consistent. The rate of family histories of thyroid cancer for fathers and siblings were not different according to the thyroid cancer onset, while that of mothers were higher in participants with a younger age at onset (<50 years old group, 11/523 [2.1%], p = 0.007). This study demonstrated that thyroid cancer incidence was associated with thyroid cancer family history. This supports regular examination of individuals with a family history of thyroid cancer to prevent disease progression and ensure early management.

Occupational risks of thyroid cancer: Data from the swedish cancer-environment register, 1961-1979

1990 ◽  
Vol 18 (5) ◽  
pp. 535-540 ◽  
Author(s):  
John M. Carstensen ◽  
Gun Wingren ◽  
Thomas Hatschek ◽  
Mats Fredriksson ◽  
Helle Noorlind-Brage ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Data ◽  
Occupational Risks

scholarly journals Impact of Extent of Surgery on Survival for Papillary Thyroid Cancer Patients Younger Than 45 Years

2015 ◽  
Vol 100 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Mohamed Abdelgadir Adam ◽  
John Pura ◽  
Paolo Goffredo ◽  
Michaela A. Dinan ◽  
Terry Hyslop ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Papillary Thyroid Cancer ◽  
Extent Of Resection ◽  
Stage I ◽  
Papillary Thyroid ◽  
Cancer Data ◽  
Thyroid Lobectomy ◽  
Extent Of Surgery ◽  
The Impact

Abstract Context: Papillary thyroid cancer (PTC) patients &lt;45 years old are considered to have an excellent prognosis; however, current guidelines recommend total thyroidectomy for PTC tumors &gt;1.0 cm, regardless of age. Objective: Our objective was to examine the impact of extent of surgery on overall survival (OS) in patients &lt;45 years old with stage I PTC of 1.1 to 4.0 cm. Design, Setting, and Patients: Adult patients &lt;45 years of age undergoing surgery for stage I PTC were identified from the National Cancer Data Base (NCDB, 1998–2006) and the Surveillance, Epidemiology, and End Results dataset (SEER, 1988–2006). Main Outcome Measure: Multivariable modeling was used to compare OS for patients undergoing total thyroidectomy vs lobectomy. Results: In total, 29 522 patients in NCDB (3151 lobectomy, 26 371 total thyroidectomy) and 13 510 in SEER (1379 lobectomy, 12 131 total thyroidectomy) were included. Compared with patients undergoing lobectomy, patients having total thyroidectomy more often had extrathyroidal and lymph node disease. At 14 years, unadjusted OS was equivalent between total thyroidectomy and lobectomy in both databases. After adjustment, OS was similar for total thyroidectomy compared with lobectomy across all patients with tumors of 1.1 to 4.0 cm (NCDB: hazard ratio = 1.45 [confidence interval = 0.88–2.51], P = 0.19; SEER: 0.95 (0.70–1.29), P = 0.75) and when stratified by tumor size: 1.1 to 2.0 cm (NCDB: 1.12 [0.50–2.51], P = 0.78; SEER: 0.95 [0.56–1.62], P = 0.86) and 2.1 to 4.0 cm (NCDB: 1.93 [0.88–4.23], P = 0.10; SEER: 0.94 [0.60–1.49], P = 0.80). Conclusions: After adjusting for patient and clinical characteristics, total thyroidectomy compared with thyroid lobectomy was not associated with improved survival for patients &lt;45 years of age with stage I PTC of 1.1 to 4.0 cm. Additional clinical and pathologic factors should be considered when choosing extent of resection.

Analysis of the rising incidence of thyroid cancer using the Surveillance, Epidemiology and End Results national cancer data registry

Surgery ◽  
2010 ◽  
Vol 148 (6) ◽  
pp. 1147-1153 ◽  
Author(s):  
John D. Cramer ◽  
Pingfu Fu ◽  
Karem C. Harth ◽  
Seunghee Margevicius ◽  
Scott M. Wilhelm
Keyword(s):  
Thyroid Cancer ◽  
Cancer Data ◽  
Data Registry ◽  
Rising Incidence ◽  
End Results

scholarly journals Analyses of the Association between Thyroid Cancer and Osteoporosis/Fracture Histories: A Cross-Sectional Study Using KoGES HEXA Data

2021 ◽  
Vol 18 (9) ◽  
pp. 4732
Author(s):  
Young-Ju Jin ◽  
Chang-Myeon Song ◽  
Bum-Jung Park ◽  
Hyo-Geun Choi
Keyword(s):  
Thyroid Cancer ◽  
Cross Sectional Study ◽  
Control Group ◽  
Entire Group ◽  
Sectional Study ◽  
Epidemiology Study ◽  
Cross Sectional ◽  
Cancer Group ◽  
Fracture History ◽  
Osteoporosis Fracture

(1) Background: The purpose of this study was to determine the association among thyroid cancer, osteoporosis and fracture history. (2) Methods: The data collected from 2004 through 2016 for the Korean Genome and Epidemiology Study were retrieved. For a total of 1349 participants with thyroid cancer and 163,629 control participants, the odds ratios (ORs) with 95% confidence intervals (CIs) of osteoporosis and fracture history were evaluated using a logistic regression model. (3) Results: The adjusted ORs of osteoporosis comparing thyroid cancer with the control group were 1.41 (95% CI = 1.18–1.70, p < 0.001) for all participants and 1.43 (95% CI = 1.19–1.71, p < 0.001) for women. The adjusted ORs of fracture history comparing these two groups were not significantly associated within the entire group of participants, men only or women only. (4) Conclusions: The adjusted OR of osteoporosis was significantly higher than 1, comparing thyroid cancer with the control group, especially in women. The adjusted OR of fractures was not significantly higher than 1, comparing the thyroid cancer group with the control group.

scholarly journals Relation between the vitamin D status and the occurrence and severity of thyroid malignancy

2021 ◽  
Vol 17 (7) ◽  
pp. 557-561
Author(s):  
L.A. Nikitiuk ◽  
Korsak Yu.
Keyword(s):  
Vitamin D ◽  
Thyroid Cancer ◽  
Vitamin D Deficiency ◽  
Large Volume ◽  
Observational Studies ◽  
Medical Literature ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
Vdr Gene ◽  
Cancer Data

Background. In spite of large volume of data linking vitamin D with cardiovascular morbidity, autoimmunity, cancer, and virtually every organ system, vitamin D and thyroid is a lesser-known aspect of vitamin D in clinical practice. The association between vitamin D deficiency and thyroid cancer is controversial. Some studies have demonstrated that higher serum vitamin D levels might protect against thyroid cancer, whereas others have not, or have even indicated the opposite to to be the case. This review intends to highlight the current literature on the impact of vitamin D status on thyroid cancer. Materials and methods. References for this review were identified through searches of PubMed for articles published to from 2005 to June 2021 using the terms “thyroid cancer” and “vitamin D”. Results. A large volume of medical literature is available from observational studies linking vitamin D with thyroid cancer. Data from interventional studies documenting beneficial effects of vitamin D on thyroid autoimmunity is also available, but lesser than that from observational studies. Short-term high dose oral vitamin D supplementation reduces TPOAb titers. Certain vitamin D receptor (VDR) gene polymorphism have been linked to increased occurrence of autoimmune thyroid disorders. Vitamin D deficiency, decreased circulating calcitriol has been linked to increased thyroid cancer. Certain VDR gene polymorphisms have been linked with increased as well as decreased occurrence of thyroid cancer. Data is scant on use of vitamin D and its analogues for treating thyroid cancer. The results suggest that Vitamin D deficiency may have value as a negative prognostic indicator in papillary thyroid cancer and that pre-operative laboratory evaluation may be less useful. This is important because Vitamin D deficiency is modifiable. Conclusions. In spite of large volume of medical literature from observational studies linking vitamin D with thyroid cancer, meaningful concrete clinical data on impact of vitamin D supplementation on hard clinical end points in these disorders is lacking, and should be the primary area of research in the next decade.

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