Abstract 276: Obesity Even Without Co-morbidity Harbors more Cardiovascular Structural and Functional Abnormalities than what you think! Time for Early CV Screening!
Purpose: To determine the extent of structural and functional cardiovascular (CV) abnormalities in asymptomatic obese subjects with and without untreated comorbidities. Methods: We evaluated 2174 consecutive asymptomatic subjects, age 25 to 80, who presented to our Cardiovascular Disease (CVD) Assessment Center for CVD risk evaluation, utilizing Early CVD Risk Score [ECVDRS]. ECVDRS, also known as Rasmussen Risk Score (RRS), consists of 10 non-invasive tests: large (C1) and small artery (C2) stiffness, blood pressure (BP) at rest and post mild exercise (PME), carotid intima media thickness (CIMT), abdominal aorta and left ventricular ultrasound, retinal photography, microalbuminuria, ECG, and pro-BNP. Fasting lipid panel and blood sugar were measured for each subject. Obesity was assessed using waist circumference measurement (> 35 inches for female and 40 inches for male). Co morbidities were defined as BP>140/90mmHg, LDL>130mg/dl, HDL<40 mg/dl for male and <50 mg/dl for female, TrG>150mg/dl, and FBS>100mg/dl. Results: Among the subjects screened 949(44%) met criteria for obesity, 458(48%) were not receiving any CV medications and were divided in two groups: A 100 subjects (22%) with no comorbidities (CM): 68 (68%) female and 32(32%) male; and group B - 358 subjects (78%) with CM: 199(56%) female and 159(44%) male. The presence of CVD abnormalities among the subjects in the different groups is shown in Picture 1. Conclusions: 1. Obesity is very prevalent disease in Sarasota County-close to 50% in our study. 2. Co morbidity superimposed on obesity did alter significantly the incidence of abnormal C2 and BP rise PME, while there was only slight increase in the incidence of CIMT abnormalities.3. Based on our data early evaluation for structural and functional cardiovascular abnormalities in obese subjects will help risk stratification and appropriate therapeutic intervention to delay or overt future catastrophic events