scholarly journals Leucas aspera to Treat Pan Oral Disorders - An Experimental Study.

2019 ◽  
Vol 1 (Issue 1) ◽  
pp. 26-33
Author(s):  
S. Karthika Nagarajan ◽  
Vidya Rani ◽  
Aravindhababu Narayanasamy ◽  
Mahaboob Kadar Masthan
Keyword(s):  
Experimental Study ◽  
Plant Extract ◽  
Phytochemical Analysis ◽  
Leucas Aspera ◽  
Raw 264.7 Macrophage Cells ◽  
Consistent Increase ◽  
Anti Inflammatory ◽  
High Level ◽  
Powder Extract ◽  
Inflammatory Effect

This article aimed at discussing the effectiveness of developing a new antioxidant and anti-inflammatory product from the natural source namely the extract of Leucas aspera plant that can be used to treat various oral mucosal conditions. The study was a descriptive experimental study. The dried powder extract of the whole LA plant was subjected to various procedures such as phytochemical analysis, antioxidant assay (DPPH) and assessment of anti-inflammatory effect (Cytokine activity in RAW 264.7 macrophage cells) and the results were tabulated. Significance of anti-inflammatory activity was tested by T-test. Our analysis has confirmed that 100µg of plant extract showed high amount of antioxidant activity (78%). The cytokine inhibitory percentage of our plant extract showed consistent increase when tested from 250 ug/ml to 1000ug/ml to be from 24% to 39% thus demonstrating significantly high level of anti-inflammatory potential (P > 0.01). Our study suggests that LA plant can be safely utilized for testing and developing products based on its extract.

scholarly journals Leucas aspera to Treat Pan Oral Disorders - An Experimental Study

2019 ◽  
pp. 26-33
Author(s):  
S. Karthika Nagarajan ◽  
Vidya Rani ◽  
Aravindhababu Narayanasamy ◽  
Mahaboob Kadar Masthan
Keyword(s):  
Experimental Study ◽  
Plant Extract ◽  
Phytochemical Analysis ◽  
Leucas Aspera ◽  
Raw 264.7 Macrophage Cells ◽  
Consistent Increase ◽  
Anti Inflammatory ◽  
High Level ◽  
Powder Extract ◽  
Inflammatory Effect

This article aimed at discussing the effectiveness of developing a new antioxidant and anti-inflammatory product from the natural source namely the extract of Leucas aspera plant that can be used to treat various oral mucosal conditions. The study was a descriptive experimental study. The dried powder extract of the whole LA plant was subjected to various procedures such as phytochemical analysis, antioxidant assay (DPPH) and assessment of anti-inflammatory effect (Cytokine activity in RAW 264.7 macrophage cells) and the results were tabulated. Significance of anti-inflammatory activity was tested by T-test. Our analysis has confirmed that 100µg of plant extract showed high amount of antioxidant activity (78%). The cytokine inhibitory percentage of our plant extract showed consistent increase when tested from 250 ug/ml to 1000ug/ml to be from 24% to 39% thus demonstrating significantly high level of anti-inflammatory potential (P > 0.01). Our study suggests that LA plant can be safely utilized for testing and developing products based on its extract.

scholarly journals PRELIMINARY PHYTOCHEMICAL SCREENING AND ANTI-INFLAMMATORY EFFECT OF THE AQUEOUS EXTRACT OF TABERNAEMONTANA DIVARICATA FLOWER IN WISTER RATS

2017 ◽  
pp. 9-12
Author(s):  
Deepankar Garga ◽  
Trishna Das
Keyword(s):  
Aqueous Extract ◽  
Inflammatory Activity ◽  
Phytochemical Analysis ◽  
Standard Drug ◽  
Tabernaemontana Divaricata ◽  
Rat Paw Edema ◽  
Oil Extract ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Inflammatory Effect

Objective: To determine the phytochemical analysis and anti-inflammatory effect of the aqueous extract of Tabernaemontanadivaricata flower in Wister Rats.Methods: The aqueous extract of fresh flowers of the plant Tabernaemontanadivaricata (family-Apocyanaceae) were prepared and analyzed for phytochemical constituents using standard methods. The anti-inflammatory activity of the plant extracts was examined with the help of rat models by taking diclofenac as a standard drug against T. divericata oil extract by using carrageenan induced rat paw edema method with the help of the instrument plethesmometer.Results: The present experiment shows the phytochemical analysis, anti-inflammatory activity of the aqueous extract of fresh flowers of the plant Tabernaemontanadivaricata (family-Apocyanaceae). Various phytochemical analysis revealed the presence of saponins, flavonoids, glycosides, steroids, proteins, phenols, amino acids and tannins. The oil extract of the plant showed much effective anti-inflammatory activity against the standard drug.Conclusion: It can be concluded aqueous extract of the flower of the plant Tabernaemontanadivaricata (family-Apocyanaceae) contain the high presence of phytochemicals. This extract was found to possess promising antimicrobial activity when compared with the standards.

scholarly journals Intestinal Anti-Inflammatory Activity ofBaccharis dracunculifoliain the Trinitrobenzenesulphonic Acid Model of Rat Colitis

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Sílvia Helena Cestari ◽  
Jairo Kennup Bastos ◽  
Luiz Claudio Di Stasi
Keyword(s):  
Lipid Peroxidation ◽  
Plant Extract ◽  
Inflammatory Activity ◽  
Glutathione Depletion ◽  
Phytochemical Analysis ◽  
Coumaric Acid ◽  
Brain Membrane ◽  
Anti Inflammatory ◽  
Improve Health

Baccharis dracunculifoliaDC (Asteraceae) is a Brazilian medicinal plant popularly used for its antiulcer and anti-inflammatory properties. This plant is the main botanical source of Brazilian green propolis, a natural product incorporated into food and beverages to improve health. The present study aimed to investigate the chemical profile and intestinal anti-inflammatory activity ofB. dracunculifoliaextract on experimental ulcerative colitis induced by trinitrobenzenosulfonic acid (TNBS). Colonic damage was evaluated macroscopically and biochemically through its evaluation of glutathione content and its myeloperoxidase (MPO) and alkaline phosphatase activities. Additionalin vitroexperiments were performed in order to test the antioxidant activity by inhibition of induced lipid peroxidation in the rat brain membrane. Phytochemical analysis was performed by HPLC using authentic standards. The administration of plant extract (5 and 50 mg kg−1) significantly attenuated the colonic damage induced by TNBS as evidenced both macroscopically and biochemically. This beneficial effect can be associated with an improvement in the colonic oxidative status, since plant extract prevented glutathione depletion, inhibited lipid peroxidation and reduced MPO activity. Caffeic acid,p-coumaric acid, aromadendrin-4-O-methyl ether, 3-prenyl-p-coumaric acid, 3,5-diprenyl-p-coumaric acid and baccharin were detected in the plant extract.

scholarly journals Anti-Inflammatory Effect on Colitis and Modulation of Microbiota by Fermented Plant Extract Supplementation

Fermentation ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 55
Author(s):  
Manabu Sugimoto ◽  
Toshiro Watanabe ◽  
Motoko Takaoka ◽  
Kyoko Suzuki ◽  
Tadatoshi Murakami ◽  
...  
Keyword(s):  
Plant Extract ◽  
Fecal Microbiota ◽  
Fermented Food ◽  
Fermented Foods ◽  
Bloody Stool ◽  
Microbiota Composition ◽  
Inflammation Markers ◽  
Positive Group ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Although results of recent studies suggest that fermented foods strongly affect the gut microbiota composition and that they relieve inflammatory bowel disease symptoms, some reports have described that fermented foods increase some inflammation markers based on differences in fermented food materials. This study evaluated the effects of fermented plant extract (FPE) on dextran sulfate sodium (DSS)-induced colitis in mice and the effects on fecal microbiota composition in humans. Mice fed 5% FPE with 3% DSS (FPE group) showed no body weight loss, atrophy of colonic length, or bloody stool, similar to mice fed a basal diet (negative group), whereas mice fed 3% DSS (positive group) exhibited those effects. Concentrations of inflammation markers IL-6 and TNF-α were not significantly different between FPE and negative groups; however, those concentrations became higher in the positive group. 16S ribosomal RNA gene sequencing was used to characterize fecal microbiota in healthy women before and after 3-month FPE supplementation. The FPE supplementation induced increases in Firmicutes phyla and in Clostridiales order, which play a central role in inflammation suppression. These results suggest that FPE enhances Clostridiales growth in the gut and that it has an anti-inflammatory effect.

scholarly journals The use of hyaluronic acid preparations for the treatment of osteoarthritis of the major joints

2021 ◽  
Vol 4 (2) ◽  
pp. 11-16
Author(s):  
O Kalashnikov ◽  
O Sulyma ◽  
T Osadchuk ◽  
V Zayets ◽  
T Nizalov ◽  
...  
Keyword(s):  
Side Effects ◽  
Adverse Side Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
High Level ◽  
Time Of Administration ◽  
Inflammatory Effect ◽  
The Ideal

The authors of the article analyzed the experience of domestic and foreign experts in the effectiveness of the use of HA preparations in the treatment of osteoarthritis of major joints. Background  and  Objective. To analyze the literature sources in order to determine the effectiveness of the use of HA preparations in the treatment of osteoarthritis of major ligaments. Materials and methods. Articles in specialized scientific journals and collections, Internet resource.Results. The analysis of literature sources determined the important role of HA preparations in the supplying and functioning of the articular cartilage. Researchers are inclined to believe that the ideal HA preparation should be as close as possible to the physiological HA of the synovial fluid of the joint. The developed domestic drug Artro-Patch fully corresponds to these parameters. Conclusions. The use of modern injectable HA preparations is advisable at stages 1–3 of OA. Anti-inflammatory effect of HA preparations makes it possible to reduce the dose and time of administration of non-steroidal anti-inflammatory drugs and, as a consequence, reduce the risk of developing many adverse side effects of NSAIDs. The high level of safety of HA preparations, the absence of serious side effects during their long-term use determine their widespread use in the clinical practice of modern orthopedists.

Sign in / Sign up

Export Citation Format

Share Document