scholarly journals Synthesis of new spiroheterocycles-fused isoxazoline from 2-arylidenes-3-phenyl-1-indanones through a regio-and diastereospecific 1,3-dipolar cycloaddition

2021 ◽  
Vol 11 (2) ◽  
pp. 194
Author(s):  
Asmae Mahfoud ◽  
Abdelali Kerbal ◽  
Asmae Nakkabi ◽  
Mohamed EL Yazidi ◽  
Mohamed AKHAZZANE ◽  
...  
Keyword(s):  
Spectral Data ◽  
Spectroscopic Data ◽  
Dipolar Cycloaddition

<p>New spiroisoxazolines <strong>3</strong> have been synthesized by 1,3-dipolar cycloaddition of arylnitrile oxides with 2-arylidenes-3-phenyl-1-indanones. The reaction occurs in a regiospecific and diastereospecific manner and leads to one cycloadduct in all the cases. The proposed structure of the obtained cycloadducts was established based on spectroscopic data and confirmed by radiocrystallographic study. The spectral data were in favor of the observed regiochemistry and diastereoselectivity of this reaction.</p>

scholarly journals Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mohammed El Fal ◽  
Youssef Ramli ◽  
Abdelfettah Zerzouf ◽  
Ahmed Talbaoui ◽  
Youssef Bakri ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Spectroscopic Data ◽  
Heterocyclic Compounds ◽  
Dipolar Cycloaddition ◽  
Bacterial Strains ◽  
Pyrimidine Derivatives ◽  
H Nmr ◽  
Biological Interest ◽  
Mic Value

New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the basis of spectral and spectroscopic data (1H NMR,13C, IR, and MS). The antibacterial activity of the synthesized products was studied using bacterial strains:Staphylococcus aureus,Enterococcus faecalis,Escherichia coli, andPseudomonas aeruginosa. Compounds having an ethyl group showed the best activity with MIC value of 31.25 µg/mL againstStaphylococcus aureusandStreptococcus fasciens.

scholarly journals DAMMARANE-TYPE TRITERPENOIDS FROM THE STEMBARK OF CHISOCHETON PENTANDRUS (MELIACEAE)

Jurnal Kimia ◽  
2020 ◽  
pp. 89
Author(s):  
D. G. Katja ◽  
S. Salam ◽  
. Nurlelasari ◽  
D. Harneti ◽  
R. Maharani ◽  
...  
Keyword(s):  
Spectral Data ◽  
Spectroscopic Data ◽  
Hexane Extract ◽  
First Time

Two dammarane-type triterpenoids, cabraleadiol (1) and cabraleahydroxylactone (2), have been isolated from n-hexane extract of the stembark of  Chisocheton pentandrus (Meliaceae). The structure of compounds 1 and 2 were determined by spectroscopic data mainly NMR and mass as well as by comparing with previously reported spectral data. Compounds 1 and 2 were reported for the first time from Chisocheton pentandrus.   Keywords:   Cabraleadiol, Cabraleahydroxylactone, Chisocheton pentandrus, Meliaceae.

Method for predicting lignocellulose components in jute by transformed FT-NIR spectroscopic data and chemometrics

2019 ◽  
Vol 34 (1) ◽  
pp. 1-9 ◽  
Author(s):  
M. Nashir Uddin ◽  
Sohan Ahmed ◽  
Swapan Kumer Ray ◽  
M. Saiful Islam ◽  
Ariful Hai Quadery ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Spectral Data ◽  
Spectroscopic Data ◽  
Partial Least Square ◽  
Least Square ◽  
Partial Least Square Regression ◽  
Chemical Compositions ◽  
Nondestructive Technique ◽  
Jute Fibers ◽  
Calibration Techniques

Abstract In this investigation, a nondestructive technique has been developed for determining chemical composition of jute fiber by chemometric modeling with pretreated FT-NIR spectroscopic data. The chemical composition of jute fibers in wet chemical method were, 58 to 61.80 % α-cellulose, 13.0 to 21.90 % lignin, 9.89 to 16.8 % pentosan and 79.02 to 88.33 % holocellulose. FT-NIR spectral data from range 9000–4000 cm−1 of all jute samples were collected from the instrument. Spectral data of jute samples were pretreated with second order derivatives (SOD), standard normal variate (SNV) techniques and both together were used before calibration. Two chemometric calibration techniques: partial least square regression (PLSR) and artificial neural network (ANN) were assessed for predicting chemical compositions of Jute fibers. Result shows that prediction efficiency ({\text{R}^{2}}) of ANN varies from 72–99 % for calibration, validation and test datasets. However, by PLSR, {\text{R}^{2}} are much higher and consistent than those by earlier one. For α-cellulose, lignin, pentosan and holocellulose {\text{R}^{2}} values hover around 95–99 %. Thereby, a non-destructive, simple and cost effective novel method is being proposed to determine chemical compositions of jute with pretreated FT-NIR spectral data and chemometric calibration techniques.

Synthesis of 2-Methylheptadecane and 14-Methylpentadecan-3-one

1994 ◽  
Vol 59 (3) ◽  
pp. 721-724 ◽  
Author(s):  
Jasvinder Singh ◽  
Ajay K. Arora ◽  
Amandeep Kaur ◽  
Goverdhan L. Kad
Keyword(s):  
Sex Pheromone ◽  
Spectral Data ◽  
Spectroscopic Data ◽  
Ether Extract ◽  
Facile Synthesis ◽  
Tiger Moth ◽  
The Family

2-Methylheptadecane (I) is the sex pheromone of the family Arctiidae (tiger moth) and was isolated by Roelof and Carde and assigned structure I on the basis of spectral data. Haque et al. isolated a granular white solid (m.p. 80 °C) from the ether extract of dried and powdered plant of Parthenium hysterophorous L. (Compositae) and proposed its structure, 14-methylpentadecan-3-one (II) on the basis of spectroscopic data. We report herein a short and facile synthesis of these compounds.

Syntheses of Anomeric Pairs of New C-Nucleosides via 1,3-Dipolar Cycloaddition Reaction, Part II

1997 ◽  
Vol 52 (11) ◽  
pp. 1393-1400 ◽  
Author(s):  
Zahida Maqboor ◽  
Mashooda Hasan ◽  
Kevin T. Potts ◽  
Abdul Malik ◽  
Tanveer Ahmad Nizami ◽  
...  
Keyword(s):  
Comparative Study ◽  
Spectral Data ◽  
Cycloaddition Reaction ◽  
Azomethine Ylides ◽  
Dipolar Cycloaddition ◽  
Reasonable Degree ◽  
Subsequent Hydrolysis

Abstract 1,3-Dipolar cycloaddition of dipolarophiles (1) and (2) with endocyclic heterocyclic azomethine ylides (4), (14) and (24), prepared in situ, leads to the protected β-and α-C-nucleo-sides (7), (8), (17), (18), (27) and (28), respectively. These, on subsequent hydrolysis, provide the corresponding C-nucleosides. The structures of all the synthesized com pounds are con­ firmed through analytical and spectral data. The assignment of configuration at C -1′ position of the C-nucleosides could be done by a comparative study of the properties of the corre­sponding α and β anomers with a reasonable degree of certainity.

scholarly journals Synthesis and properties of new fused pyrrolo-1,10-phenanthroline type derivatives

2021 ◽  
pp. 57-57
Author(s):  
Cristina Al-Matarneh ◽  
Irina Rosca ◽  
Sergiu Shova ◽  
Ramona Danac
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Spectroscopic Data ◽  
Molecular Structures ◽  
Dipolar Cycloaddition ◽  
Synthetic Approach ◽  
Good Activity ◽  
Substituted Acetylenes ◽  
Potential Antimicrobial Activity

New fused pyrrolo-phenanthroline type derivatives were synthesized, in two steps, from 1,10-phenanthroline and evaluated for antimicrobial activity and fluorescence properties. Our synthetic approach involved a 3+2 dipolar-cycloaddition of some selected N-substituted 1,10-phenanthrolin-1-ium ylides, (m)ethoxycarbonyl and cyano (1,2-di)substituted acetylenes and alkenes, respectively. The structures of compounds were supported by analytical and spectroscopic data. Molecular structures of four compounds have also been also determined by monocrystal XRD analyses. All synthesized compounds were then evaluated for their potential antimicrobial activity against Staphylococcus aureus ATCC25923, Escherichia coli ATCC25922 and Candida albicans ATCC10231. Two of the compounds demonstrated good activity against the above tested strains.

scholarly journals Melicope moluccana Antimalarial Activity of Furoquinoline Alkaloids from the Leaves of Melicope moluccana

2020 ◽  
Vol 5 (2) ◽  
pp. 138-142
Author(s):  
Ryan Ayub Wahjoedi ◽  
Ratih Dewi Saputri ◽  
Tjitjik Srie Tjahjandarie ◽  
Mulyadi Tandjung
Keyword(s):  
Plasmodium Falciparum ◽  
Spectral Data ◽  
Spectroscopic Data ◽  
Chemical Structure ◽  
Antimalarial Activity ◽  
2D Nmr ◽  
Esi Ms ◽  
Ic50 Values

Two furoquinoline alkaloids, leptanoine C (1) and haplopine-3,3´-dimethylallyl ether (2) were isolated from the leaves of Melicope moluccana. The chemical structure of both compounds was determined based on spectroscopic data, including UV, IR, HR-ESI-MS, 1D, and 2D NMR spectral data. The antimalarial activity of compounds 1-2 against Plasmodium falciparum 3D7 showing their IC50 values are 0.18 ppm and 2.28 µg/mL, respectively.

Five-coordinate Bromobis(dialkyldithiocarbamate) Complexes of Arsenic, Antimony, and Bismuth

1975 ◽  
Vol 53 (10) ◽  
pp. 1530-1535 ◽  
Author(s):  
George E. Manoussakis ◽  
Constantinos A. Tsipis ◽  
Christos C. Hadjikostas
Keyword(s):  
Spectral Data ◽  
Electronic Spectra ◽  
Spectroscopic Data ◽  
Bidentate Ligand ◽  
Dithiocarbamate Group

Fifteen bromobis(dialkyldithiocarbamate) complexes of arsenic, antimony, and bismuth have been prepared by reacting the corresponding tris(dialkyldithiocarbamates) with bromine. The structure of these compounds is studied by i.r., n.m.r., and electronic spectra. From the interpretation of the spectroscopic data it is deduced that each dithiocarbamate group acts as a bidentate ligand. The spectral data are discussed and compared to those of the corresponding tris(dialkyldithiocarbamate) complexes.

Comportement particulier d'arylidènebenzothiazinonedioxydes dans les cycloadditions [3 + 2]. Compétition entre sites dipolarophiliques. Évolution des cycloadduits

1994 ◽  
Vol 72 (6) ◽  
pp. 1424-1428 ◽  
Author(s):  
Toufik Fathi ◽  
Kabula Ciamala ◽  
Nguyen Dinh An ◽  
Joël Vebrel
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Spectroscopic Data ◽  
Dipolar Cycloaddition ◽  
Nuclear Magnetic

The reaction of diphenylnitrilimine with some arylidenebenzothiazinone dioxides leads to a mixture of two products that were isolated by chromatography. Spectroscopic data (infrared, nuclear magnetic resonance) and a radiocrystallographic study illustrate a competition between the two dipolarophilic sites in dipolar cycloaddition.

scholarly journals Synthesis and Evaluation of Cytotoxic Activity on Mcf-7 Cell Line of Some Diesters Derived from 5-(Hydroxybenzylidene)Thiazolidine-2,4-Diones

2018 ◽  
Vol 26 (2) ◽  
pp. 233-248
Author(s):  
Hieu Quang Tran ◽  
Hien Cao Nguyen ◽  
Thin Van Nguyen ◽  
Thanh Thi Nguyen ◽  
Toan Ngoc Vo ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Line ◽  
Spectral Data ◽  
Knoevenagel Condensation ◽  
Cycloaddition Reaction ◽  
Chloroacetic Acid ◽  
Dipolar Cycloaddition ◽  
Significant Activity ◽  
Mcf 7 ◽  
C Nmr

Abstract Knoevenagel condensation of thiazolidine-2,4-dione, which were prepared from chloroacetic acid and thioure by 1,3 dipolar cycloaddition reaction, with 2-hydroxybenzaldehyde, 5-bromo-2-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde and 4-hydoxy-3-methoxybezaldehyde gave five corresponding 5-(hydroxybenzylidene)thiazolidine-2,4-dione compounds. The reaction of 5-(hydroxybenzylidene)thiazolidine-2,4-diones and ethyl chlorofomate or ethyl chloroacetate occurred at both NH and OH centers and gave ten corresponding diesters. The structures of the diesters were confirmed by IR, MS, 1H and 13C-NMR spectral data. However, in test for cytotoxic activity against MCF-7 cells, none of the diester compounds exhibited significant activity.

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