scholarly journals The Influence of an Acute Bout of Aerobic Exercise on Vascular Endothelial Function in Moderate Stages of Chronic Kidney Disease

Life ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 91
Author(s):  
Jeffrey S. Forsse ◽  
Zacharias Papadakis ◽  
Matthew N. Peterson ◽  
James Kyle Taylor ◽  
Burritt W. Hess ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Endothelial Function ◽  
Aerobic Exercise ◽  
Dependent Measure ◽  
Paraoxonase 1 ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Post Exercise

Chronic kidney disease (CKD) is directly influenced by the deleterious effects of systemic inflammation and oxidative stress. The vascular endothelium may transiently respond to aerobic exercise and improve post-exercise vascular renal function in moderate stages of CKD. Brachial artery flow-mediated dilation (FMD) is a nitric-oxide-dependent measure of endothelial function that is transiently potentiated by exercise. The purpose of the study was to determine the acute influence of a single bout of high-intensity interval exercise (HIIE) or steady-state moderate-intensity exercise (SSE) on endothelial dysfunction in moderate stages of CKD. Twenty participants (n = 6 men; n = 14 women) completed 30 min of SSE (65%) and HIIE (90:20%) of VO2reserve in a randomized crossover design. FMD measurements and blood samples were obtained before, 1 h, and 24 h post-exercise. FMD responses were augmented 1 h post-exercise in both conditions (p < 0.005). Relative to pre-exercise measures, total antioxidant capacity increased by 4.3% 24 h post-exercise (p = 0.012), while paraoxonase-1 was maintained 1 h and elevated by 6.1% 24 h after SSE, but not HIIE (p = 0.035). In summary, FMD can be augmented by a single episode of either HIIE or SSE in moderate stages of CKD. Modest improvements were observed in antioxidant analytes, and markers of oxidative stress were blunted in response to either SSE or HIIE.

scholarly journals Acute effects of intradialytic aerobic exercise on solute removal, blood gases and oxidative stress in patients with chronic kidney disease

2017 ◽  
Vol 39 (2) ◽  
Author(s):  
Joseane Böhm ◽  
Mariane Borba Monteiro ◽  
Francini Porcher Andrade ◽  
Francisco Veríssimo Veronese ◽  
Fernando Saldanha Thomé
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aerobic Exercise ◽  
Blood Gases ◽  
Acute Effects ◽  
And Oxidative Stress

scholarly journals Endothelial Function and Oxidative Stress in Chronic Kidney Disease of Varying Severity and the Effect of Acute Hemodialysis

Renal Failure ◽  
2011 ◽  
Vol 33 (4) ◽  
pp. 411-417 ◽  
Author(s):  
Ambar Khaira ◽  
Sandeep Mahajan ◽  
Atin Kumar ◽  
Anoop Saraya ◽  
Suresh C. Tiwari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Endothelial Function ◽  
And Oxidative Stress

PSX-A-18 Late-Breaking: Oxidative stress biomarkers in blood plasma of moderately exercised horses

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 372-372
Author(s):  
Elizabeth Ott ◽  
Clay A Cavinder ◽  
Caleb O Lemley ◽  
Thu Dinh
Keyword(s):  
Oxidative Stress ◽  
Blood Plasma ◽  
Repeated Measures ◽  
Fixed Effects ◽  
Moderate Intensity ◽  
Thiobarbituric Acid Reactive Substance ◽  
Moderate Intensity Exercise ◽  
Oxidative Stress Biomarkers ◽  
Post Exercise ◽  
In Blood Plasma

Abstract Oxidative stress by physical stressors negatively impacts the performance of equine athletes. The present study was aimed to determine oxidative biomarkers in blood plasma of exercising horses. Stock-type horses were subject to a standardized moderate intensity exercise protocol following NRC guidelines 3 times per wk for 8 wk. Blood plasma was collected in wk 1, 2, 7, and 8 immediately before and 0, 30, 60, and 90 min after exercise and analyzed for total antioxidant capacity (TAC), thiobarbituric acid reactive substance (TBARS), glutathione peroxidase activity (GPx), and superoxide dismutase activity (SOD). Data were analyzed as repeated measures with wk, d, time, and their interactions as fixed effects. The TAC on d 2 (0.40 mM trolox) were 7.5% greater than that on d 3 (P = 0.013). There were wk × d × time interactions for SOD, TBARS, and GPx (P &lt; 0.001). The TBARS remained at d-1 wk-1 pre-exercise baseline (2.70 µM malondialdehyde) for most collection times within wk 1, 7, and 8 (P ≥ 0.058); however, TBARS increased by 0.24 to 0.41 µM on d 2 of wk 2 post-exercise (P &lt; 0.001) and remained similarly elevated on d 3 pre- and immediately post-exercise (P &lt; 0.001). The GPx similarly remained at baseline (172.57 µM/min; P ≥ 0.621) but increased by 48.18 to 83.36 µM/min at most collection times on d 1 and 2 of wk 2 (P ≤ 0.023). The SOD remained at baseline (167.21 µM/min; P ≥ 0.055) until increasing by 11.28 to 15.61 µM/min at 30 min post-exercise on d 1, wk 1 and at most collection times on d 3, wk 8 (P ≤ 0.043). The current study indicates the time-dependent nature of oxidative stress in relation to persistent stressors such as exercise.

scholarly journals Acute exercise does not impair renal function in nondialysis chronic kidney disease patients regardless of disease stage

2017 ◽  
Vol 313 (2) ◽  
pp. F547-F552 ◽  
Author(s):  
Davi A. Santana ◽  
Jacques R. Poortmans ◽  
Egidio Lima Dórea ◽  
Juliana Bannwart de Andrade Machado ◽  
Alan Lins Fernandes ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Aerobic Exercise ◽  
Acute Exercise ◽  
Exercise Bout ◽  
Peak Oxygen Uptake ◽  
Disease Stage ◽  
Moderate Intensity ◽  
Impair Renal Function

Exercise has been overlooked as a potential therapy in chronic kidney disease (CKD), mainly because of a lack of understanding on its safety aspects. Notably, there are no data on renal function after exercise in CKD considering its stages. We investigated the acute effects of a 30-min moderate-intensity aerobic exercise bout on glomerular filtration rate (GFR) and albuminuria in 22 nondialysis CKD patients divided into: CKD stages 1 and 2 (CKD1–2) and CKD stages 3 and 4 (CKD3–4). Eleven body mass index-, age-, and sex-matched healthy individuals served as control (CON). Blood and urine samples were collected before, immediately after, and up to 90 min postexercise for creatinine and albumin assessments. GFR was determined by creatinine clearance (GFRCr-Cl). All CKD patients had significantly lower peak oxygen uptake than CON. CKD1–2 and CKD3–4 had increasingly higher serum creatinine than CON (9.6 ± 2.6, 25.6 ± 1.01, and 7.5 ± 1.4 mg/l, respectively); however, no within-group changes in serum or urinary creatinine were observed across time. GFRCr-Cl was decreased in CKD1–2 and CKD3–4 compared with CON (91 ± 17 ml·min−1·1.73 m−2; 34 ± 15 ml·min−1·1.73 m−2; 122 ± 20 ml·min−1·1.73 m−2, respectively). Most importantly, exercise did not affect GFRCr-Cl in none of the groups across time. Albuminuria was significantly higher in CKD3–4 (297 ± 284 µg/min) than in CON (5.4 ± 1.4 µg/min), but no within-group changes were observed after exercise. In conclusion, a single 30-min moderate-intensity aerobic exercise bout does not impair renal function in nondialysis CKD patients, regardless of disease stage, supporting the notion that exercise training can be safe in this disease.

scholarly journals One-week cocoa flavanol intake increases prefrontal cortex oxygenation at rest and during moderate-intensity exercise in normoxia and hypoxia

2018 ◽  
Vol 125 (1) ◽  
pp. 8-18 ◽  
Author(s):  
Lieselot Decroix ◽  
Cajsa Tonoli ◽  
Elodie Lespagnol ◽  
Constantino Balestra ◽  
Amandine Descat ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Endothelial Function ◽  
Antioxidant Capacity ◽  
Near Infrared ◽  
Tissue Oxygenation ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Double Blind ◽  
Exercise Induced

During exercise in hypoxia, O2 delivery to brain and muscle is compromised, and oxidative stress is elicited. Cocoa flavanols (CF) have antioxidant capacities and can increase blood flow by stimulating endothelial function. We aimed to examine the effects of 7-day CF intake on oxidative stress, nitric oxide production, and tissue oxygenation in response to exercise in normobaric hypoxia (14.3% O2). In a randomized, double-blind, cross-over study, 14 well-trained male cyclists completed four trials: exercise in normoxia or hypoxia, after 7-day CF or placebo intake. Flow-mediated dilation (FMD) was measured before intake of the last dose CF or placebo. One hundred minutes later, 20-min steady-state (SS; 45% V̇o2max) and 20-min time trial (TT) (cycling) were performed. Blood samples were taken. Prefrontal and muscular oxygenation was assessed by near-infrared spectroscopy. At baseline, FMD was increased by CF. Hypoxia increased exercise-induced elevations in lipid peroxidation and antioxidant capacity. CF suppressed exercise-induced lipid peroxidation but did not influence antioxidant capacity. At rest and during SS, prefrontal and muscular oxygenation was decreased by hypoxia. CF elevated prefrontal oxygenation but did not impact muscular oxygenation. During TT, hypoxia accelerated the exercise-induced decrease in prefrontal oxygenation, but not in muscular oxygenation. During TT, CF did not alter prefrontal and muscular oxygenation. CF did not change plasma nitrite, nitrate, and arginine:citrulline. During high-intensity exercise, CF improved neither tissue oxygenation nor performance in well-trained athletes. At rest and during moderate-intensity exercise, CF reduced exercise-induced lipid peroxidation and partially restored the hypoxia-induced decline in prefrontal oxygenation. NEW & NOTEWORTHY For the first time, we showed that CF had beneficial effects on endothelial function at rest, as well as on prefrontal oxygenation at rest and during moderate-intensity exercise, both in normoxia and hypoxia. Moreover, we showed that CF intake inhibited oxidative stress during exhaustive exercise in hypoxia.

scholarly journals Tratment With Folic Acid Increases Paraoxonase 1 Activity Thereby Improving Chronic Kidney Disease

2020 ◽  
Author(s):  
Andressa Matsumoto ◽  
Michael Maes ◽  
Ana Paula Michelin ◽  
Kamila Bonifácio ◽  
Laura Semeão ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Folic Acid ◽  
Kidney Disease ◽  
Antioxidant Defenses ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Renal Disease Progression ◽  
Ckd Stage ◽  
Before And After

Introduction: Increased oxidative stress, including elevated homocysteine (Hcy) plasma levels, and lowered levels of antioxidants participate in the pathophysiology and progression of chronic kidney disease (CKD). Paraoxonase (PON)1 activity and folic acid are antioxidants which play a role in Hcy metabolism. However, there are no data whether, in CKD, treatment with folic acid improves glomerular filtration rate (GFR) through effects on PON1 activity and Hcy concentrations. Methods: In the current study, we determined PON1 genotypes and activity, Hcy and estimated GFR (eGFR) both before and after treatment with folic acid (5 mg/d) versus no treatment during three consecutive months in 113 outpatients with CKD classified into stages 4, 3b and 3a. Results: PON1 CMPAase and AREase activities were significantly lower in patients allocated to CKD stage 4 as compared with stages 3b and 3a. Treatment with folic acid significantly improved eGFR and increased levels of CMPAase and AREase in patients allocated to classes 4 and 3b, but not 3a. The improvement of eGFR was associated with increased CMPAase and AREase activities, while the latter were associated with increased levels of folic acid. Treatment with folic acid significantly reduced plasma Hcy levels and the Hcy/PON1 activity ratio. The effects of folic acid increasing PON1 activities were not mediated by changes in Hcy. Discussion: Treatment of CKD patients in early/intermediate stages of CKD patients improves oxidative stress by rebalancing the prooxidant (Hcy) / antioxidant (PON1 activities) ratio. Treatment with folic acid significantly improves eGFR and these effects are mediated via increased PON1 activities. Treatment with folic acid in phase G3b and G4 may reduce renal disease progression by enhancing antioxidant defenses.

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