A Ferrofluid with Surface Modified Nanoparticles for Magnetic Hyperthermia and High ROS Production

A ferrofluid with 1,2-Benzenediol-coated iron oxide nanoparticles was synthesized and physicochemically analyzed. This colloidal system was prepared following the typical co-precipitation method, and superparamagnetic nanoparticles of 13.5 nm average diameter, 34 emu/g of magnetic saturation, and 285 K of blocking temperature were obtained. Additionally, the zeta potential showed a suitable colloidal stability for cancer therapy assays and the magneto-calorimetric trails determined a high power absorption density. In addition, the oxidative capability of the ferrofluid was corroborated by performing the Fenton reaction with methylene blue (MB) dissolved in water, where the ferrofluid was suitable for producing reactive oxygen species (ROS), and surprisingly a strong degradation of MB was also observed when it was combined with H2O2. The intracellular ROS production was qualitatively corroborated using the HT-29 human cell line, by detecting the fluorescent rise induced in 2,7-dichlorofluorescein diacetate. In other experiments, cell metabolic activity was measured, and no toxicity was observed, even with concentrations of up to 4 mg/mL of magnetic nanoparticles (MNPs). When the cells were treated with magnetic hyperthermia, 80% of cells were dead at 43 °C using 3 mg/mL of MNPs and applying a magnetic field of 530 kHz with 20 kA/m amplitude.

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Ni-Cu Nanoparticles and Their Feasibility for Magnetic Hyperthermia

Nanomaterials ◽

10.3390/nano10101988 ◽

2020 ◽

Vol 10 (10) ◽

pp. 1988 ◽

Cited By ~ 1

Author(s):

Bianca P. Meneses-Brassea ◽

Edgar A. Borrego ◽

Dawn S. Blazer ◽

Mohamed F. Sanad ◽

Shirin Pourmiri ◽

...

Keyword(s):

Magnetic Hyperthermia ◽

Biological Tissues ◽

Superparamagnetic Nanoparticles ◽

Blocking Temperature ◽

Ferromagnetic Behavior ◽

Cytotoxicity Test ◽

Cu Nanoparticles ◽

Hyperthermia Treatment

Ni-Cu nanoparticles have been synthesized by reducing Ni and Cu from metal precursors using a sol–gel route followed by annealing at 300 °C for 1, 2, 3, 6, 8, and 10 h for controlled self-regulating magnetic hyperthermia applications. Particle morphology and crystal structure revealed spherical nanoparticles with a cubic structure and an average size of 50, 60, 53, 87, and 87 nm for as-made and annealed samples at 300 °C for 1, 3, 6, and 10 h, respectively. Moreover, hysteresis loops indicated ferromagnetic behavior with saturation magnetization (Ms) ranging from 13–20 emu/g at 300 K. Additionally, Zero-filed cooled and field cooled (ZFC-FC) curves revealed that each sample contains superparamagnetic nanoparticles with a blocking temperature (TB) of 196–260 K. Their potential use for magnetic hyperthermia was tested under the therapeutic limits of an alternating magnetic field. The samples exhibited a heating rate ranging from 0.1 to 1.7 °C/min and a significant dissipated heating power measured as a specific absorption rate (SAR) of 6–80 W/g. The heating curves saturated after reaching the Curie temperature (Tc), ranging from 30–61 °C within the therapeutic temperature limit. An in vitro cytotoxicity test of these Ni-Cu samples in biological tissues was performed via exposing human breast cancer MDA-MB231 cells to a gradient of concentrations of the sample with 53 nm particles (annealed at 300 °C for 3 h) and reviewing their cytotoxic effects. For low concentrations, this sample showed no toxic effects to the cells, revealing its biocompatibility to be used in the future for in vitro/in vivo magnetic hyperthermia treatment of cancer.

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Modification of Fe3O4 superparamagnetic nanoparticles with zirconium oxide; preparation, characterization and its application toward fluoride removal

RSC Advances ◽

10.1039/c5ra14833b ◽

2015 ◽

Vol 5 (88) ◽

pp. 72058-72068 ◽

Cited By ~ 27

Author(s):

F. Riahi ◽

M. Bagherzadeh ◽

Z. Hadizadeh

Keyword(s):

Aqueous Solutions ◽

Zirconium Oxide ◽

Superparamagnetic Nanoparticles ◽

Precipitation Method ◽

Fluoride Removal ◽

Co Precipitation

Fe3O4 superparamagnetic nanoparticles (NPs) modified with zirconia (ZrO2) were synthesized (Fe3O4@ZrO2) using a chemical co-precipitation method and used as a nanoadsorbent in the removal of excessive fluoride from aqueous solutions.

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BIODEGRADABLE GELATIN DECORATED Fe3O4 NANOPARTICLES FOR PACLITAXEL DELIVERY

Vietnam Journal of Science and Technology ◽

10.15625/2525-2518/55/1b/12085 ◽

2018 ◽

Vol 55 (1B) ◽

pp. 7 ◽

Cited By ~ 2

Author(s):

Dai Hai Nguyen

Keyword(s):

Fe3o4 Nanoparticles ◽

Drug Loading ◽

Spherical Shape ◽

Average Diameter ◽

Precipitation Method ◽

Loop Analysis ◽

Transmission Electron ◽

Potential Applications ◽

Size And Morphology ◽

Co Precipitation

The objective of this study is to prepare biodegradable iron oxide nanoparticles with gelatin (GEL) for paclitaxel (PTX) delivery. In detail, Fe3O4 nanoparticles were prepared and then coated them with GEL (Fe3O4@GEL) conjugate by co–precipitation method. Furthermore, the formation of Fe3O4@GEL was demonstrated by Fourier transform infrared (FT–IR) and powder X–ray diffraction (XRD). The superparamagnetic property of Fe3O4@GEL was also showed by hysteresis loop analysis, the saturation magnetization reached 20.36 emu.g–1. In addition, size and morphology of Fe3O4@GEL nanoparticles were determined by transmission electron microscopy (TEM). The results indicated that Fe3O4@GEL nanoparticles were spherical shape with average diameter of 10 nm. Especially, PTX was effectively loaded into the coated magnetic nanoparticles, 86.7 ± 3.2 % for drug loading efficiency and slowly released up to 5 days. These results suggest that the potential applications of Fe3O4@GEL nanoparticles in the development of stable drug delivery systems for cancer therapy.

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Structural, Magnetic and Electronic Properties of Nanostructured Magnetic Materials

10.26686/wgtn.17060414 ◽

2021 ◽

Author(s):

◽

Tushara Prakash

Keyword(s):

Particle Size ◽

Electrical Resistance ◽

Low Temperatures ◽

Arc Discharge ◽

Superparamagnetic Nanoparticles ◽

Precipitation Method ◽

Verwey Transition ◽

Electrostatic Charging ◽

Saturation Moment ◽

Co Precipitation

<p>This thesis was motivated by the different properties exhibited by magnetic nanoparticles when compared with the bulk. For example the coercivity and magnetocrystalline anisotropy vary with the particle size and the finite particle size can affect the spin-wave dispersion. When the nanoparticle radius becomes small enough it is possible to observe superparamagnetism with negligible hysteresis. The transport properties can also be different in nanoparticle composites when compared with the bulk. It is particularly interesting if the nanoparticles have a degree of electronic spin polarization because it is then possible to observe spin-dependent tunnelling. This thesis reports the results from a study of the structural, magnetic, and electronic properties of two partially electronically spin-polarized nanostructured compounds, iron-nickel alloy and magnetite, that were made using a new arc-discharge method, ion implantation and annealing, and a co-precipitation method. It was found that permalloy powders could be made by arc-discharge where there were a range of particle sizes from nms to 10s of microns. Magnetoresistance was observed where it is due to the ordinary magnetoresistance and spin-dependent tunnelling between the particles. It was also possible to make magnetite using the arc-discharge process and the powders contained nanoparticles, large faceted nanoparticles, and larger particles in the 10s of micron range. The temperature dependence of the saturation magnetization changes at 127 K, which can be attributed to the charge-ordering Verwey transition. A large magnetoresistance was observed and attributed to spin-dependent tunnelling between the magnetite particles. It was less than predicted due to a spin-disordered interfacial region. The electrical resistance was modelled in terms of small nanoparticles coating the larger particles and electrostatic charging during tunnelling between small nanoparticles. Magnetite powders were also synthesized via a chemical co-precipitation method where nanoparticles with diameters of ~14 nm were observed. The Verwey transition was only observed in the zero-field cooled field-cooled magnetization for the arc-discharge powders. It was observed for the magnetite powders made using both methods in the temperature dependence of the saturation moment. The saturation magnetic moment for powders made using both methods has a power law dependence on temperature with an exponent of 3/2 at low temperatures and a higher value above the Verwey transition temperature 2. There was also a large magnetoresistance due to spin-dependent tunnelling for magnetite nanoparticle made using a chemical co-precipitation method and the electrical resistance could be modelled in terms of electrostatic charging during tunnelling. NixFe₁₋x nanoparticles were made for the first time by ion beam implantation. Small superparamagnetic nanoparticles occurred after implantation. The saturation moment after implantation did not follow the Bloch’s T³/² for x=0.82, which is likely to be due to spin-waves propagating in the nanoparticle/NiyFe₁₋ySizOn matrix. A bi-modal particle size distribution of mostly spherical nanoparticles was observed for x=0.82 after annealing. An x=0.45 sample showed large asymmetric NixFe₁₋x nanoparticles with minimal smaller nanoparticles. The different nanoparticle morphologies is likely to be due to the different nucleation centres and the different initial concentration profiles. The saturation moment had an exponent of 3/2 at low temperatures and there was a contribution from surface disordered spins. A higher Ni fluence with x=0.53 lead to the formation of superparamagnetic nanoparticles that had a higher blocking temperature, indicating the formation of larger nanocrystallites. There was an enhancement in the permeability.</p>

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Tunable Magnetic Hyperthermia Properties of Pristine and Mildly Reduced Graphene Oxide/Magnetite Nanocomposite Dispersions

Nanomaterials ◽

10.3390/nano10122426 ◽

2020 ◽

Vol 10 (12) ◽

pp. 2426

Author(s):

Erzsébet Illés ◽

Etelka Tombácz ◽

Zsófia Hegedűs ◽

Tamás Szabó

Keyword(s):

Graphene Oxide ◽

Heat Production ◽

Colloidal Stability ◽

Magnetic Hyperthermia ◽

Magnetic Core ◽

Alkaline Condition ◽

Graphene Oxides ◽

Alkaline Conditions ◽

Improved Stability ◽

Co Precipitation

We present a study on the magnetic hyperthermia properties of graphene oxide/magnetite (GO/MNP) nanocomposites to investigate their heat production behavior upon the modification of the oxidation degree of the carbonaceous host. Avoiding the harsh chemical conditions of the regular in situ co-precipitation-based routes, the oppositely charged MNPs and GO nanosheets were combined by the heterocoagulation process at pH ~ 5.5, which is a mild way to synthesize composite nanostructures at room temperature. Nanocomposites prepared at 1/5 and 1/10 GO/MNP mass ratios were reduced by NaBH4 and L-ascorbic acid (LAA) under acidic (pH ~ 3.5) and alkaline conditions (pH ~ 9.3). We demonstrate that the pH has a crucial effect on the LAA-assisted conversion of graphene oxide to reduced GO (rGO): alkaline reduction at higher GO loadings leads to doubled heat production of the composite. Spectrophotometry proved that neither the moderately acidic nor alkaline conditions promote the iron dissolution of the magnetic core. Although the treatment with NaBH4 also increased the hyperthermic efficiency of aqueous GO/MNP nanocomposite suspensions, it caused a drastic decline in their colloidal stability. However, considering the enhanced heat production and the slightly improved stability of the rGO/MNP samples, the reduction with LAA under alkaline condition is a more feasible way to improve the hyperthermic efficiency of magnetically modified graphene oxides.

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PREPARATION, CHARACTERIZATION AND MAGNETIC PROPERTIES OF NANO-Fe3O4 AND COBALT-DOPED NANO-Fe3O4 BY CO-PRECIPITATION METHOD

NANO ◽

10.1142/s1793292010002116 ◽

2010 ◽

Vol 05 (04) ◽

pp. 203-214 ◽

Cited By ~ 8

Author(s):

XIAOJUAN LIANG ◽

WEIWEI HUAN ◽

XIANGCHEN JIA ◽

HAIJUN DING ◽

YUXIANG YANG ◽

...

Keyword(s):

Magnetic Properties ◽

Dopant Concentration ◽

Average Diameter ◽

Solution Concentration ◽

Precipitation Method ◽

High Coercivity ◽

Alkali Concentration ◽

Peg 4000 ◽

Nano Fe3o4 ◽

Co Precipitation

Pure nano- Fe3O4 and cobalt-doped nano- Fe3O4 particles are successfully synthesized by co-precipitation method using tetramethylammonium hydroxide (TMAOH) as alkali. Several key factors that may affect preparation are carefully discussed such as alkali concentration, alkali dosage, reaction temperature, iron salt solution concentration and dispersant agents. Such nano- Fe3O4 particles prepared have good dispersibility and a very narrow size distribution with the average diameter about 38 nm, which are proved to be cubic spinel Fe3O4 crystal by XRD pattern. It is also found that the addition of PEG-4000 surfactant can improve the dispersibility of nanoparticles. In our work, effects of cobalt dopant concentration on magnetic properties of cobalt-doped nano- Fe3O4 are also discussed. The result shows that the coercivity of cobalt-doped nanoparticles changes greatly with the variation of cobalt dopant concentration. The maximum coercivity reaches as high as 1628 Oe, which is very meaningful for preparation of materials with high coercivity.

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A Hybrid Nanocomposite from γ-Fe2O3 Nanoparticles Functionalized in the Amazon Oil Polymers matrix

International Journal for Innovation Education and Research ◽

10.31686/ijier.vol8.iss6.2435 ◽

2020 ◽

Vol 8 (6) ◽

pp. 418-425

Author(s):

Laffert Gomes Ferreira da Silva ◽

Hualan Patrício Pacheco ◽

Judes Gonçalves dos Santos ◽

Luciene Batista da Silveira

Keyword(s):

Polymeric Matrix ◽

Superparamagnetic Nanoparticles ◽

Precipitation Method ◽

Magnetic Nanocomposites ◽

Fe2o3 Nanoparticles ◽

Polymeric Nanocomposites ◽

X Ray Diffraction ◽

Carapa Guianensis ◽

Natural Oil ◽

Co Precipitation

In recent years, there was a crescent increase in studies involving hybrid magnetic nanocomposites from renewable resources, because of its importance in the synthesis of new organic biomaterials. Herein, we report a synthesis of Magnetic Nanocomposites (MNCs) from superparamagnetic nanoparticles based on iron oxide of maghemite (γ-Fe2O3) coated by a polymeric matrix. In this study, we used γ-Fe2O3 which are prepared using co-precipitation method, where salts with ions Fe+2 and Fe+3 are dissolved in distilled water and stirred until they reach about 60 ° C. Shortly after the mixture is add a solution of NH4OH. After this step, the magnetite solute (Fe3O4) is left in oxidizing solution, thus forming nanoparticles of γ-Fe2O3. For activation of the functional groups and extraction of the polymer we used polycondensation method, wherein the oil extracted from Carapa Guianensis Aubl. is diluted in ethylene glycol (C2H6O2). After that, the mixture undergoes processes: hydrothermal and isobaric-isothermal. Then, purification was performed polymer, thus obtaining a polymer of natural oil. The nanoparticles was coated for the polymeric matrix using dispersion method and freeze drying, thereby forming a hybrid MNCs ready for characterization. For the samples characterization was utilized X-ray diffraction (XRD) and spectroscopy: UV-Vis, Fourier Transform Infrared (FTIR), EDX and PAS. The results indicate that magnetic-polymeric nanocomposites structure formed was type core/shell, wherein the core was formed γ-Fe2O3 nanoparticles, coated by the polymer matrix, which presents some characteristics of the natural oil used in their synthesis. In recent years, there was a crescent increase in studies involving hybrid magnetic nanocomposites from renewable resources, because of its importance in the synthesis of new organic biomaterials. Herein, we report a synthesis of Magnetic Nanocomposites (MNCs) from superparamagnetic nanoparticles based on iron oxide of maghemite (γ-Fe2O3) coated by a polymeric matrix. In this study, we used γ-Fe2O3 which are prepared using co-precipitation method, where salts with ions Fe+2 and Fe+3 are dissolved in distilled water and stirred until they reach about 60 ° C. Shortly after the mixture is add a solution of NH4OH. After this step, the magnetite solute (Fe3O4) is left in oxidizing solution, thus forming nanoparticles of γ-Fe2O3. For activation of the functional groups and extraction of the polymer we used polycondensation method, wherein the oil extracted from Carapa Guianensis Aubl. is diluted in ethylene glycol (C2H6O2). After that, the mixture undergoes processes: hydrothermal and isobaric-isothermal. Then, purification was performed polymer, thus obtaining a polymer of natural oil. The nanoparticles was coated for the polymeric matrix using dispersion method and freeze drying, thereby forming a hybrid MNCs ready for characterization. For the samples characterization was utilized X-ray diffraction (XRD) and spectroscopy: UV-Vis, Fourier Transform Infrared (FTIR), EDX and PAS. The results indicate that magnetic-polymeric nanocomposites structure formed was type core/shell, wherein the core was formed γ-Fe2O3 nanoparticles, coated by the polymer matrix, which presents some characteristics of the natural oil used in their synthesis.

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Synthesis and Studying Induction Heating of Mn1-xZnxFe2O4 (x=0-0.5) Magnetic Nanoparticles for Hyperthermia Treatments

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.882.200 ◽

2021 ◽

Vol 882 ◽

pp. 200-218

Author(s):

S. Mahmood Hussein ◽

T.H. Mubarak ◽

S.M. Ali Ridha ◽

Jasim Al-Zanganawee

Keyword(s):

Particle Size ◽

Relaxation Time ◽

Magnetic Nanoparticles ◽

Smart Materials ◽

Average Particle Size ◽

Superparamagnetic Nanoparticles ◽

Soft Magnetic Materials ◽

Precipitation Method ◽

Average Particle ◽

Co Precipitation

The recent development of the using the magnetic nanoparticles for hyperthermia treatments emphasizes the needed of smart materials to become a safety for heat therapy. Self-regulate magnetic nanoparticles of MnZnFe2O4 may be proper for thermal treatments. Structure and magnetic properties of the synthesis Mn1-xZnx Fe2O4 with x=0- 0.5 by step 0.1were studied. Superparamagnetic nanoparticles of MnZnFe2O4 were prepared by co-precipitation method, followed that heat treatment in the autoclave reactor. XRD results showed that is difficult to prepare MnZnFe2O4 directly using the co-precipitation method. Preparation method yield nanoparticles with spherical shape and there is a slight change in the particle size distribution, also observed shrinkage occurs in the particle size after heat treatments, the average particle size was estimated about 20nm as confirmed by FESEM images. FTIR spectra of samples showed two distinct absorption peaks in the range ~ 617 – 426 (cm-1) related to stretching vibrations of the (Fe-O) in the tetrahedral and octahedral side respectively. Magnetic measurements were carried out using (VSM), M-H curves indicate typical soft magnetic materials and particles so small to be identical superparamagnetic nanoparticles. Heating ability of water based colloidal dispersions of samples were studied under magnetic field strength 6.5kA/m and the frequency 190 kHz, and the results showed when increasing Zn2+ to x=0.3 or more the samples not heated up. Depending on the heating curve susceptibility, effective relaxation time and Néel relaxation time , were determined.

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Fabrication and Up-Conversion Luminescence of Er3+:Y2O3 Nanoparticles

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2008.18173 ◽

2008 ◽

Vol 8 (3) ◽

pp. 1211-1213 ◽

Cited By ~ 1

Author(s):

Luo Jun-Ming ◽

Li Yong-Xiu ◽

Deng Li-Ping ◽

Yuan Yong-Rui ◽

Chen Wei-Fan

Keyword(s):

Doping Concentration ◽

Green Emission ◽

Average Diameter ◽

Precipitation Method ◽

Cubic Phase ◽

X Ray Diffraction ◽

X Ray ◽

Radiative Transitions ◽

Transmission Electron ◽

Co Precipitation

Y2O3 nanoparticles doped with different concentrations of Er3+ were prepared by the co-precipitation method. X-ray diffraction and transmission electron microscopy results show that Er3+ dissolves completely in the Y2O3 cubic phase. The Er3+:Y2O3 nanoparticles are homogeneous in size and nearly spherical, and the average diameter of the particles after being calcined at 1,000 °C for 2 h is in the range of 40–60 nm. When Er3+:Y2O3 nanoparticles are excited under a 980 nm diode laser, there are two main emission bands: green emission centered at 562 nm corresponding to the 4S3/2/2H11/2 → 4I15/2 radiative transitions and red emission centered at 660 nm corresponding to the 4F9/2 ∼ 4I15/2 radiative transitions. By changing the doping concentration of Er3+ ions, the up-conversion luminescence can be gradually tuned from green to red.

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FACILE SYNTHESIS OF HUMIC ACID-COATED IRON OXIDE NANOPARTICLES AND THEIR APPLICATIONS IN WASTEWATER TREATMENT

Functional Materials Letters ◽

10.1142/s1793604711002238 ◽

2011 ◽

Vol 04 (04) ◽

pp. 373-376 ◽

Cited By ~ 7

Author(s):

CHUNJIAO ZHOU ◽

ZHEN WU ◽

WENJIE ZHANG ◽

MINGXIA XIA ◽

GUOZHANG DAI ◽

...

Keyword(s):

Humic Acid ◽

Superparamagnetic Nanoparticles ◽

Precipitation Method ◽

X Ray Diffraction ◽

Facile Synthesis ◽

X Ray ◽

Removal Capacity ◽

Iron Salts ◽

Transmission Electron ◽

Co Precipitation

Humic acid (HA)-coated Fe3O4 ( Fe3O4 /HA) superparamagnetic nanoparticles were synthesized by a chemical co-precipitation method with cheap and environmental friendly iron salts and HA. The as-synthesized samples were characterized by X-ray diffraction (XRD), high resolution transmission electron microscopy (HRTEM), Fourier transform infrared spectroscopy (FTIR) and vibrating sample magnetometer (VSM). The Fe3O4 /HA nanoparticles showed faster adsorption rate and higher removal capacity of cationic organic dye Methylene blue (MB) in neutral water. Moreover, the MB desorption could be easily completed. And the reused performance of Fe3O4 /HA nanoparticles was also excellent.

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