scholarly journals Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2976
Author(s):  
Adeolu Oluwasanmi ◽  
Ernest Man ◽  
Anthony Curtis ◽  
Humphrey H. P. Yiu ◽  
Yvonne Perrie ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Scale Up ◽  
Hybrid Nanoparticles ◽  
Line Of Sight ◽  
Manufacturing Plant ◽  
Continuous Manufacturing ◽  
Know How ◽  
Similar Chemical ◽  
Continuous Manufacture ◽  
Future Potential

Hybrid iron oxide-gold nanoparticles are of increasing interest for applications in nanomedicine, photonics, energy storage, etc. However, they are often difficult to synthesise without experience or ‘know-how’. Additionally, standard protocols do not allow for scale up, and this is significantly hindering their future potential. In this study, we seek to determine whether microfluidics could be used as a new manufacturing process to reliably produce hybrid nanoparticles with the line of sight to their continuous manufacture and scaleup. Using a Precision Nano NanoAssemblr Benchtop® system, we were able to perform the intermediate coating steps required in order to construct hybrid nanoparticles around 60 nm in size with similar chemical and physical properties to those synthesised in the laboratory using standard processes, with Fe/Au ratios of 1:0.6 (standard) and 1:0.7 (microfluidics), indicating that the process was suitable for their manufacture with optimisation required in order to configure a continuous manufacturing plant.

scholarly journals Effect of Aspect Ratio on the Mixing Performance in the Kenics Static Mixer

Processes ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 464
Author(s):  
Xingren Jiang ◽  
Ning Yang ◽  
Rijie Wang
Keyword(s):  
Pharmaceutical Industry ◽  
Aspect Ratio ◽  
Flow Reactor ◽  
Mixing Time ◽  
Continuous Process ◽  
Scale Up ◽  
Influence Factors ◽  
Continuous Manufacturing ◽  
Static Mixer ◽  
Mixing Performance

Continuous manufacturing has received increasing interest because of the advantages of intrinsic safety and enhanced mass transfer in the pharmaceutical industry. However, the difficulty for scale-up has limited the application of continuous manufacturing for a long time. Recently, the tubular flow reactor equipped with the Kenics static mixer appears to be a solution for the continuous process scale-up. Although many influence factors on the mixing performance in the Kenics static mixer have been investigated, little research has been carried out on the aspect ratio. In this study, we used the coefficient of variation as the mixing evaluation index to investigate the effect of the aspect ratio (0.2–2) on the Kenics static mixer’s mixing performance. The results indicate that a low aspect ratio helps obtain a shorter mixing time and mixer length. This study suggests that adjusting the aspect ratio of the Kenics static mixer can be a new strategy for the scale-up of a continuous process in the pharmaceutical industry.

scholarly journals Hybrid nanoparticles for magnetic and plasmonic hyperthermia

2018 ◽  
Vol 20 (37) ◽  
pp. 24065-24073 ◽  
Author(s):  
Jesus G. Ovejero ◽  
Irene Morales ◽  
Patricia de la Presa ◽  
Nicolas Mille ◽  
Julian Carrey ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Plasmonic Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Oxide Nanoparticles ◽  
Au Nanorods

The present manuscript reports the use of hybrid magneto-plasmonic nanoparticles (HMPNPs) based on iron oxide nanoparticles and Au nanorods as colloidal nanoheaters.

scholarly journals Synthesis and Characterization of Iron Oxide Derivatized Mutant Cowpea Mosaic Virus Hybrid Nanoparticles

2008 ◽  
Vol 20 (24) ◽  
pp. 4816-4820 ◽  
Author(s):  
Alfredo A. Martinez‐Morales ◽  
Nathaniel G. Portney ◽  
Yu Zhang ◽  
Giuseppe Destito ◽  
Gurer Budak ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mosaic Virus ◽  
Hybrid Nanoparticles ◽  
Synthesis And Characterization ◽  
Cowpea Mosaic Virus

Paclitaxel-induced formation of 3D nanocrystal superlattices within injectable protein-based hybrid nanoparticles

2018 ◽  
Vol 54 (82) ◽  
pp. 11586-11589
Author(s):  
Jeong Yu Lee ◽  
Ho Yeon Son ◽  
Jae Chul Park ◽  
Jongnam Park ◽  
Yoon Sung Nam
Keyword(s):  
Polyethylene Glycol ◽  
Iron Oxide ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Self Assembly ◽  
Three Dimensional ◽  
Superparamagnetic Iron Oxide ◽  
Hybrid Nanoparticles ◽  
Nanocrystal Superlattices

Self-assembly of monodisperse superparamagnetic iron oxide nanocrystals into a close-packed, three-dimensional (3D) superlattice is designed within cross-linked protein-based nanoparticles composed of human serum albumin and polyethylene glycol.

Fabrication and characterization of dual acting oleyl chitosan functionalised iron oxide/gold hybrid nanoparticles for MRI and CT imaging

2018 ◽  
Vol 112 ◽  
pp. 250-257 ◽  
Author(s):  
Thiagarajan Hemalatha ◽  
Periyathambi Prabu ◽  
Dharmalingam Nandagopal Gunadharini ◽  
Marichetti Kuppuswami Gowthaman
Keyword(s):  
Iron Oxide ◽  
Ct Imaging ◽  
Hybrid Nanoparticles ◽  
Fabrication And Characterization

Development and Scale-Up of Diversion Strategy for Twin Screw Granulation in Continuous Manufacturing

2020 ◽  
Vol 109 (11) ◽  
pp. 3439-3450 ◽  
Author(s):  
Pallavi Pawar ◽  
Don Clancy ◽  
Lee Gorringe ◽  
Steve Barlow ◽  
Alex Hesketh ◽  
...  
Keyword(s):  
Scale Up ◽  
Continuous Manufacturing ◽  
Twin Screw ◽  
Twin Screw Granulation

scholarly journals High Temperature Continuous Flow Syntheses of Iron Oxide Nanoflowers Using the Polyol Route in a Multi-Parametric Millifluidic Device

Nanomaterials ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 119
Author(s):  
Enzo Bertuit ◽  
Sophie Neveu ◽  
Ali Abou-Hassan
Keyword(s):  
High Temperature ◽  
Iron Oxide ◽  
Physical Properties ◽  
High Temperatures ◽  
Continuous Flow ◽  
Large Scale ◽  
Materials Science ◽  
Continuous Process ◽  
Scale Up ◽  
Chemical Yield

One of the most versatile routes for the elaboration of nanomaterials in materials science, including the synthesis of magnetic iron oxide nanoclusters, is the high-temperature polyol process. However, despite its versatility, this process still lacks reproducibility and scale-up, in addition to the low yield obtained in final materials. In this work, we demonstrate a home-made multiparametric continuous flow millifluidic system that can operate at high temperatures (up to 400 °C). After optimization, we validate its potential for the production of nanomaterials using the polyol route at 220 °C by elaborating ferrite iron oxide nanoclusters called nanoflowers (CoFe2O4, Fe3O4, MnFe2O4) with well-controlled nanostructure and composition, which are highly demanded due to their physical properties. Moreover, we demonstrate that by using such a continuous process, the chemical yield and reproducibility of the nanoflower synthesis are strongly improved as well as the possibility to produce these nanomaterials on a large scale with quantities up to 45 g per day.

Integrated continuous manufacturing in pharmaceutical industry: current evolutionary steps toward revolutionary future

2019 ◽  
Vol 8 (4) ◽  
pp. 139-161 ◽  
Author(s):  
Nada A Helal ◽  
Ola Elnoweam ◽  
Heba Abdullah Eassa ◽  
Ahmed M Amer ◽  
Mohamed Ashraf Eltokhy ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Process Development ◽  
State Of The Art ◽  
Scale Up ◽  
Pharmaceutical Products ◽  
Continuous Manufacturing ◽  
Monitoring And Control ◽  
Pharmaceutical Manufacturers ◽  
On Line ◽  
And Control

Continuous manufacturing (CM) has the potential to provide pharmaceutical products with better quality, improved yield and with reduced cost and time. Moreover, ease of scale-up, small manufacturing footprint and on-line/in-line monitoring and control of the process are other merits for CM. Regulating authorities are supporting the adoption of CM by pharmaceutical manufacturers through issuing proper guidelines. However, implementation of this technology in pharmaceutical industry is encountered by a number of challenges regarding the process development and quality assurance. This article provides a background on the implementation of CM in pharmaceutical industry, literature survey of the most recent state-of-the-art technologies and critically discussing the encountered challenges and its future prospective in pharmaceutical industry.

scholarly journals Advances in Magnetic Noble Metal/Iron-Based Oxide Hybrid Nanoparticles as Biomedical Devices

2019 ◽  
Vol 6 (3) ◽  
pp. 75 ◽  
Author(s):  
Laura M. Sanchez ◽  
Vera A. Alvarez
Keyword(s):  
Iron Oxide ◽  
Noble Metal ◽  
Biomedical Applications ◽  
Hybrid Nanoparticles ◽  
Noble Metal Nanoparticles ◽  
Iron Oxide Nanoparticle ◽  
Cooperative Effects ◽  
Catalytic Activities ◽  
Structure Morphology ◽  
Oxide Nanoparticle

The study of the noble metal magnetic hybrid nanoparticles is a really promising topic from both the scientific and the technological points of views, with applications in several fields. Iron oxide materials which are hybridized with noble metal nanoparticles (NPs) have attracted increasing interest among researchers because of their cooperative effects on combined magnetic, electronic, photonic, and catalytic activities. This review article contains a summary of magnetic noble metal/iron oxide nanoparticle systems potentially useful in practical biomedical applications. Among the applications, engineered devices for both medical diagnosis and treatments were considered. The preparation to produce different structures, as blends or core-shell structures, of several nanometric systems was also considered. Several characterization techniques available to describe the structure, morphology and different kinds of properties of hybrid nanoparticles are also included in this review.

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