Association of Serum Vitamin D Levels with Disease Activity in Male Patients with Ankylosing Spondylitis

Background:Axial spondyloarthritis (axSpA) is a chronic inflammatory disease predominantly involving the axial skeleton and sacroiliac joints. Although the exact aetiology remains largely unknown, there is thought to be an immune-driven element. Vitamin D deficiency has been associated with a number of autoimmune diseases and is thought to play an important role in modulating the immune system. Low vitamin D levels may contribute to the development and progression of axSpA1.Objectives:To study the possible associations between low vitamin D and disease activity in axSpA.Methods:A systematic literature search using Medline, Embase and Cochrane was performed using MESH search terms “ankylosing spondylitis”, “axial spondyloarthropathy” and “vitamin D”. Articles examining disease activity measured by BASDAI, ASDAS-CRP, ESR and CRP identified through title/abstract screening, were included in the study, with relevant information extracted.Results:Out of 495 articles identified from the initial search, 19 observational studies which were mostly (89%) cross-sectional studies were identified. There was considerable heterogeneity between studies, including in the definition of vitamin D deficiency, latitude where study took place and seasonal variation. Vitamin D levels were often lower in patients with axSpA compared to controls. Seventeen studies found no association with vitamin D deficiency and disease activity. The exceptions included one study which measured serum vitamin D receptor levels as opposed to serum 25 (OH) D or 1,25 (OH)2 D concentrations, and another study whose recruitment occurred over four years and therefore seasonal variation may conflict results. Patients taking NSAIDs or anti-TNF had no difference in vitamin D levels.Conclusion:Vitamin D deficiency is more prevalent in axSpA but does not seem to associate with increased disease activity. Longitudinal studies are required to better define these links.References:[1]Sizheng Z, et al. Systematic review of association between vitamin D levels and susceptibility and disease activity of ankylosing spondylitis. Rheumatology 2014; 53:1595-1603.Disclosure of Interests:None declared

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Rate of hypovitaminosis D and association of plasma concentration of 25(OH)D with indicators of disease activity in patients with rheumatoid arthritis

Doklady of the National Academy of Sciences of Belarus ◽

10.29235/1561-8323-2020-64-6-723-729 ◽

2020 ◽

Vol 64 (6) ◽

pp. 723-729

Author(s):

A. V. Rudenko ◽

T. D. Tyabut ◽

A. E. Buglova ◽

G. A. Babak ◽

P. M. Morozik ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Disease Activity ◽

Vitamin D Deficiency ◽

Activity Index ◽

Serum Vitamin ◽

Disease Activity Index ◽

Tender Joint Count ◽

Serum Vitamin D ◽

Vitamin D Levels

Vitamin D deficiency is an important environmental risk factor that influences the prevalence and severity of several autoimmune diseases, including rheumatoid arthritis (RA). The aim of this study was to determine the incidence of vitamin D insufficiency and deficiency in patients with RA, to establish the relationship between serum vitamin D levels and indicators of disease activity. 156 patients with RA were included in the study, mean age 60.2 ± 13.9 years. Assessment of clinical status was performed, serum concentrations of rheumatoid factor (RF), C-reactive protein (CRP), total vitamin D (25(OH)D), antibodies to cyclic citrullinated peptide (ACCP) were determined. RA disease activity was evaluated using DAS28 (disease activity score), SDAI (Simplified Disease Activity Index) и CDAI (Clinical Disease Activity Index) scores. Average levels of 25(OH)D in the surveyed sample were 25.2 ± 13.2 ng/ml. The results of the study indicate a high prevalence of vitamin D deficiency in patients with RA. Normal indicators of vitamin D, its insufficiency and deficiency were observed in 47 (30.3 %), 45 (28.7 %) and 64 (40.7 %) patients, respectively. Low level of serum 25(OH)D was associated with higher indices of RA activity according to DAS28, SDAI and CDAI, as well as with greater tender joint count. Vitamin D should be prescribed as an adjunctive therapy in patients with active RA due to its potential immunomodulatory effect, as well as for the prevention and treatment of bone metabolism disorders.

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Serum Vitamin D Levels in Male Blood Donors and Male Patients Coinfected With Human Immunodeficiency Virus and Tuberculosis: A Comparative Study

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqy092.159 ◽

2018 ◽

Vol 150 (suppl_1) ◽

pp. S64-S65

Author(s):

Carol Njeru

Keyword(s):

Vitamin D ◽

Human Immunodeficiency Virus ◽

Comparative Study ◽

Blood Donors ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Immunodeficiency Virus ◽

Male Patients

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Continuous Positive Airway Pressure Treatment Increases Serum Vitamin D Levels in Male Patients with Obstructive Sleep Apnea

Journal of Clinical Sleep Medicine ◽

10.5664/jcsm.4766 ◽

2015 ◽

Vol 11 (06) ◽

pp. 603-607 ◽

Cited By ~ 15

Author(s):

Claudio Liguori ◽

Andrea Romigi ◽

Francesca Izzi ◽

Nicola Biagio Mercuri ◽

Alberto Cordella ◽

...

Keyword(s):

Vitamin D ◽

Obstructive Sleep Apnea ◽

Airway Pressure ◽

Positive Airway Pressure ◽

Serum Vitamin ◽

Pressure Treatment ◽

Serum Vitamin D ◽

Obstructive Sleep ◽

Vitamin D Levels ◽

Male Patients

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Serum Vitamin D levels in Rheumatoid arthritis and Relationship with disease activity

Bulletin of Egyptian Society for Physiological Sciences ◽

10.21608/besps.2018.8206 ◽

2018 ◽

Vol 38 (2) ◽

pp. 175-184

Author(s):

Azza Elamir ◽

Tarek Ibrahim ◽

Nermeen Fouad ◽

Mohamed Masoud

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Disease Activity ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels

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Influence of Vitamin D Deficiency on Inflammatory Markers and Clinical Disease Activity in IBD Patients

Nutrients ◽

10.3390/nu11051059 ◽

2019 ◽

Vol 11 (5) ◽

pp. 1059 ◽

Cited By ~ 9

Author(s):

Pedro López-Muñoz ◽

Belén Beltrán ◽

Esteban Sáez-González ◽

Amparo Alba ◽

Pilar Nos ◽

...

Keyword(s):

Vitamin D ◽

Disease Activity ◽

Inflammatory Markers ◽

Intestinal Inflammation ◽

Serum Vitamin ◽

Clinical Disease ◽

Faecal Calprotectin ◽

Clinical Disease Activity ◽

Serum Vitamin D ◽

Vitamin D Levels

Vitamin D has recently been discovered to be a potential immune modulator. Low serum vitamin D levels have been associated with risk of relapse and exacerbation of clinical outcomes in Crohn’s disease (CD) and ulcerative colitis (UC). A retrospective, longitudinal study was conducted to determine the association between vitamin D levels and inflammatory markers and clinical disease activity in inflammatory bowel disease (IBD). In addition, circulating 25(OH)D3 progression was evaluated according to vitamin D supplementation. Participants were separated into three groups according to their vitamin D level: severe deficiency (SD), moderate deficiency (MD) and sufficiency (S). Serum 25(OH)D3 was inversely correlated with faecal calprotectin (FC) for CD and UC but was only correlated with C-reactive protein (CRP) for UC patients. In the multivariate analysis of FC, CRP and fibrinogen (FBG), we predicted the presence of a patient in the SD group with 80% accuracy. A deficiency of 25(OH)D3 was associated with increased hospitalisations, flare-ups, the use of steroids and escalating treatment. Supplemental doses of vitamin D were likely to be insufficient to reach adequate serum levels of 25(OH)D3. Vitamin D intervention studies are warranted to determine whether giving higher doses of vitamin D in IBD might reduce intestinal inflammation or disease activity.

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