The relationship of serum vitamin D receptor levels with disease activity and clinical parameters in patients with ankylosing spondylitis

Background and aims: Vitamin D deficiency is a known pandemic problem which has thousands of bad health outcomes. The aim of the current study was to investigate the effect of maternal vitamin D, Ca, and PO4 levels on growth indexes of newborns at birth and 1 month and 3 months after delivery in pregnant women admitted to Hajar hospital of Shahrekord, Iran in 2016. Materials and Methods: This descriptive-analytical study was conducted on 196 pregnant women admitted to the hospital. During pregnancy, 5 mL of mother’s blood and 5 mL of umbilical cord blood were taken. Serum calcium and phosphorus levels were determined immediately after sampling and then centrifuged. After collecting the samples, 25-OHD levels were measured by ELISA method. Neonatal growth indexes such as weight, height, and head circumference atbirth,1 month, and 3 months were measured. Data were analyzed using independent samples t test, ANOVA, and correlation coefficient by SPSS version 16.0. Results: Deficiency of vitamin D, phosphorus, and calcium was observed in 76%, 1%, and 25% of women, respectively. Moreover, deficiency of vitamin D, phosphorus, and calcium was reportedin56.1%, 15.8%, and 9.2% of newborns, respectively. There was a significant relationship between calcium level in newborns and their weight and height at birth, one month, and three months of age ( P<0.05). Levels of vitamin D, calcium and phosphorus of mother and newborns were significantly correlated ( P<0.05). Conclusion: More than two-thirds of mothers and more than half of the newborns were deficient in vitamin D. There was also a lack of calcium in one third of mothers and 9.2% of newborns, and phosphorus deficiency was observed only in 1% of mothers and 15.8% of newborns. Due to the low intake of these materials through nutrition, the supplementation of these substances, especially vitamin D and calcium, is required during pregnancy.

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Exploring the relationship between vitamin D and mania: correlations between serum vitamin D levels and disease activity

Nordic Journal of Psychiatry ◽

10.1080/08039488.2018.1424238 ◽

2018 ◽

Vol 72 (3) ◽

pp. 221-225 ◽

Cited By ~ 6

Author(s):

Neslihan Altunsoy ◽

Rabia Nazik Yüksel ◽

Merve Cingi Yirun ◽

Ayşegül Kılıçarslan ◽

Çiğdem Aydemir

Keyword(s):

Vitamin D ◽

Disease Activity ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Relationship

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Association of Serum Vitamin D Levels with Disease Activity in Male Patients with Ankylosing Spondylitis

Turkish Journal of Osteoporosis ◽

10.4274/tod.68736 ◽

2016 ◽

Vol 22 (3) ◽

pp. 125-128

Author(s):

Nilgün Mesci ◽

Duygu Geler Külcü ◽

Sevilay Çüçen Batıbay ◽

Pınar Duygu Eroğlu

Keyword(s):

Vitamin D ◽

Ankylosing Spondylitis ◽

Disease Activity ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Male Patients

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Evaluation of the relationship of serum vitamin D levels in COVID-19 patients with clinical course and prognosis

Tuberkuloz ve Toraks ◽

10.5578/tt.70027 ◽

2020 ◽

Vol 68 (3) ◽

pp. 227-235

Author(s):

Buğra Kerget ◽

Ferhan Kerget ◽

Ahmet Kızıltunç ◽

Abdullah Osman Koçak ◽

Ömer Araz ◽

...

Keyword(s):

Vitamin D ◽

Clinical Course ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Relationship Of ◽

The Relationship

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AB0673 SHINING LIGHT ON AXIAL SPONDYLOARTHRITIS: DISEASE ACTIVITY AND VITAMIN D. WHAT’S THE LINK?

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.4684 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1631.1-1632

Author(s):

G. A. Brown ◽

K. M. Torsney ◽

E. Nikiphorou

Keyword(s):

Vitamin D ◽

Seasonal Variation ◽

Ankylosing Spondylitis ◽

Disease Activity ◽

Vitamin D Deficiency ◽

Axial Spondyloarthritis ◽

Serum Vitamin ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels

Background:Axial spondyloarthritis (axSpA) is a chronic inflammatory disease predominantly involving the axial skeleton and sacroiliac joints. Although the exact aetiology remains largely unknown, there is thought to be an immune-driven element. Vitamin D deficiency has been associated with a number of autoimmune diseases and is thought to play an important role in modulating the immune system. Low vitamin D levels may contribute to the development and progression of axSpA1.Objectives:To study the possible associations between low vitamin D and disease activity in axSpA.Methods:A systematic literature search using Medline, Embase and Cochrane was performed using MESH search terms “ankylosing spondylitis”, “axial spondyloarthropathy” and “vitamin D”. Articles examining disease activity measured by BASDAI, ASDAS-CRP, ESR and CRP identified through title/abstract screening, were included in the study, with relevant information extracted.Results:Out of 495 articles identified from the initial search, 19 observational studies which were mostly (89%) cross-sectional studies were identified. There was considerable heterogeneity between studies, including in the definition of vitamin D deficiency, latitude where study took place and seasonal variation. Vitamin D levels were often lower in patients with axSpA compared to controls. Seventeen studies found no association with vitamin D deficiency and disease activity. The exceptions included one study which measured serum vitamin D receptor levels as opposed to serum 25 (OH) D or 1,25 (OH)2 D concentrations, and another study whose recruitment occurred over four years and therefore seasonal variation may conflict results. Patients taking NSAIDs or anti-TNF had no difference in vitamin D levels.Conclusion:Vitamin D deficiency is more prevalent in axSpA but does not seem to associate with increased disease activity. Longitudinal studies are required to better define these links.References:[1]Sizheng Z, et al. Systematic review of association between vitamin D levels and susceptibility and disease activity of ankylosing spondylitis. Rheumatology 2014; 53:1595-1603.Disclosure of Interests:None declared

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The Relationship of Serum Vitamin D Levels and the Framingham Risk Score among Male Workers in the Manufacturing Sector

Korean Journal of Occupational and Environmental Medicine ◽

10.35371/kjoem.2012.24.2.115 ◽

2012 ◽

Vol 24 (2) ◽

pp. 115 ◽

Cited By ~ 3

Author(s):

Seung-Hyun Park ◽

Young-Wook Kim ◽

Chang-Ho Chae ◽

Jun-Seok Son ◽

Chan-Woo Kim ◽

...

Keyword(s):

Vitamin D ◽

Risk Score ◽

Framingham Risk Score ◽

Manufacturing Sector ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Framingham Risk ◽

Vitamin D Levels ◽

Relationship Of ◽

The Relationship

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Serum Vitamin D and Pyridinoline Cross-Linked Carboxyterminal Telopeptide of Type I Collagen in Patients with Ankylosing Spondylitis

BioMed Research International ◽

10.1155/2015/543806 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Pingping Zhang ◽

Qiuxia Li ◽

Qiujing Wei ◽

Zetao Liao ◽

Zhiming Lin ◽

...

Keyword(s):

Vitamin D ◽

Ankylosing Spondylitis ◽

Disease Activity ◽

Activity Index ◽

Serum Vitamin ◽

Type I ◽

Mineral Density ◽

Serum Vitamin D ◽

Serum Ictp ◽

Hip Bmd

Objective. To assess the serum vitamin D and ICTP levels in patients with ankylosing spondylitis (AS) and investigate their relationship with disease activity and bone mineral density (BMD).Method. 150 patients and 168 controls were included. Serum 25(OH)D, ICTP, C-reaction protein (CRP), Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), and Hip BMD were assessed in patients. 25(OH)D and ICTP were detected in controls.Results. The serum 25(OH)D in AS was 57.92 ± 24.42 nmol/L, significantly lower than controls (91.24 ± 42.02 nmol/L). Serum ICTP in AS was 5.72 ± 3.88 ug/L, significantly higher than controls (3.69 ± 1.26 ug/L). ICTP level was higher in men than in women patients (6.07 ± 4.05 versus 3.84 ± 1.96 ug/L,P≤0.01); it was also higher in JAS than in AAS (9.52 ± 3.79 versus 5.27 ± 3.65 ug/L,P≤0.01). Furthermore, 25(OH)D was negatively correlated with ICTP. Low 25(OH)D and high ICTP were one of the reasons of AS patients’ low hip BMD. Besides, a significant relationship was found between serum ICTP and CRP.Conclusion. There was a high incidence of vitamin D inadequacy in AS. Serum ICTP level was elevated in AS, especially in JAS and male patients. 25(OH)D and ICTP seem to be valuable markers to detect bone loss in AS.

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