Analisis Korelasi Pre Eklampsia Dalam Kehamilan Dengan Kejadian Asfiksia Neonatorum

Asphyxia neonatorum is the failure of the newborn to breathe spontaneously and regularly, causing further disturbances. The onset of asphyxia in infants with pre-eclamptic mothers is due to high blood pressure causing reduced blood delivery to the placenta, this will reduce the supply of oxygen and food for the baby. As a result, the baby's development is slow, and intrauterine hypoxia occurs. The purpose of this study was to determine the correlation between pre-eclampsia in pregnancy and the incidence of asphyxia neonatorum in the NICU Room of the Mataram City Hospital, NTB in 2020. The research method used in this study was analytical correlational with a case control design with a retrospective time approach. The population is the data of all women giving birth in the NICU Room of Mataram City Hospital in 2020 as many as 1,098 people. The sampling technique used was systematic random sampling so that the number of samples obtained was 124 samples. The tools used are medical records. The statistical analysis used was the chi square test. The results showed that of the 124 samples studied, the neonatal asphyxia infants in mothers with pre-eclampsia were 39 (62.9%) compared to 23 (37.1%) non-preeclamptic mothers, the results of the probability value (p value) = 0.000 <α 0.05, by itself Ho is rejected, which means that there is a relationship between pre-eclampsia and newborn asphyxia at the Mataram City Hospital. So it can be concluded that, mothers who experience preeclampsia tend to have neonatal asphyxia. It is recommended that health workers at the Mataram City Hospital to further improve the quality of health services to the community, especially mothers giving birth, to keep their health checked at the health service place so that the risk of pre-eclampsia can be prevented.

Prevalence and determinants of asphyxia neonatorum among live births at Debre Tabor General Hospital, North Central Ethiopia: a cross-sectional study

Background: More than one third of the neonatal deaths at Neonatal Intensive Care Unit of Debre Tabor General Hos- pital (DTGH) are attributable to birth asphyxia. Most of these neonates are referred from maternity ward of the hospital. However, there is no recent evidence on the prevalence and specific determinants of birth asphyxia at DTGH. Besides, public health importance of factors like birth spacing weren’t addressed in the prior studies. Methods: A cross sectional study was conducted on a sample of 240 newborns at delivery ward. The collected data were cleaned, coded and entered into Epi -data version 4.2 and exported to Stata version 14. Binary logistic regression model was considered and statistical significance was declared at P< 0.05 using adjusted odds ratio. Results: The prevalence of asphyxia neonatorum was 6.7 % based on the fifth minute APGAR score. From multi-variable logistic regression analysis, antenatal obstetric complications (AOR = 2.63, 95% CI: 3.75, 14.29), fetal malpresentation (AOR = 3.17, 95% CI: 1.21, 15.20), premature rupture of fetal membranes (AOR = 6.56, 95% CI: 3.48, 18.12) and meconium stained amniotic fluid (AOR = 2.73, 95% CI: 1.76, 14.59) were significant predictors. Conclusion: The prevalence of fifth minute asphyxia neonatorum was relatively low. Fortunately, its predictors are modifi- able. Thus, we can mitigate the problem even with our limited resources such as enhancing the existing efforts of antenatal and intra-partum care, which could help early detection and management of any obstetric and neonatal health abnormality.” Keywords: Birth asphyxia; asphyxia neonatorum; prevalence; determinants; Ethiopia.

The Role Of Corticosteroid Administration On The Incidents Of Asphyxia Neonatorum Among Mothers With Preterm Delivery In Ponek Rsud Jombang

The causes of death for newborns 0-6 days in Indonesia are 36.9% respiratory disorders, 32.4% premature birth, 12% sepsis, 6.8% hypothermia, and 6.6% neonatal jaundice. A preliminary study in Comprehensive Emergency Services Neonatal Obstetric (PONEK) of Jombang Regional Public Hospital (RSUD Jombang) reported that the incidence of asphyxia neonatorum was 295 cases in 2016 and 341 cases in 2015. There were 98 cases of preterm delivery in 2016. This study aims to prove the effect of corticosteroid administration on neonatal asphyxia in mothers with preterm delivery. This study was an analytical study using a one-group after only design. The population was all women giving birth at RSUD Jombang with preterm labor diagnosis in January-May 2017, while the sample was 82. The instruments utilized questionnaires and checklists. The bivariate analysis applied the chi-square association test. Based on the results of the chi-square test χ2= 4.622> χ2 table; p = 0.009 <α (0.05). There was a correlation between corticosteroid administration and the incidence of asphyxia neonatorum in women with preterm delivery. This study's results could be an input for primary health care facilities to prevent neonatal asphyxia. Further research should develop other similar variables and increase the number of respondents.

Oral herbal medicine for women with intrahepatic cholestasis in pregnancy: a systematic review of randomized controlled trials

Background Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy complication whose range has been calculated to be between 0.01 and 15.6% all around the world. We wanted to systematically evaluate the effect and safety of oral herbal medicine on treatment for ICP. Methods Details of the methods could be found in the registered protocol on PROSPERO (CRD42018096013). Trials assessing the effectiveness of herbal medicine for ICP were searched from seven electronic databases from inception to 28th February 2020. RevMan 5.3 software was used to perform all statistical analysis. Meta-analysis, additional analysis, Trial Sequential Analysis (TSA) and Grading of Recommendations Assessment, Development and Evaluation (GRADE) were conducted if data permitted. Results Totally 43 randomized controlled trials with 3556 patients were included. Meta-analysis showed potential good adjunctive effect of herbal medicine on decreasing the pruritus scores (MD -0.58, 95% CI − 0.79 to − 0.36), the serum TBA scores (MD − 3.99 μmol/L, 95% CI − 4.24 to − 3.74) on the basis with Ursodesoxycholic acid. Compared to the medicine alone, significantly lower incidence of fetal distress (RR 0.41, 95% CI 0.32 to 0.51), asphyxia neonatorum (RR 0.35, 95%CI 0.25 to 0.49), cesarean section (RR 0.73, 95% CI 0.63 to 0.85), postpartum hemorrhage (RR 0.45, 95% CI 0.28 to 0.72) were observed in the combination group. But the comparison between herbal medicine and medicine showed inconsistent results among trials. Insufficient information could be used to evaluate the safety of herbal medicine for ICP. Conclusion This review found the current evidence may support the effectiveness of combination of herbal medicine and conventional medicine for decreasing the maternal pruritus scores, the serum TBA, and the number of fetal distress, or asphyxia neonatorum events related to this condition (which was supported by TSA results). Since there were obvious statistical and clinical heterogeneity among trials, and the methodological quality of the included studies was poor, the level of the evidence could only be defined as “very low” according to the GRADE criteria. Further high quality studies are still needed to testify the effectiveness and safety of herbal medicine for ICP.

Hubungan Antara Paritas Dan Partus Lama Dengan Kejadian Asfiksia Neonatorum Pada Bayi Baru Lahir Di Rumah Sakit Umum Daerah Kota Prabumulih Tahun 2019

Asphyxia Neonatorum is a failure to start and continue breathing spontaneously and regularly when a new baby is born or some time after birth. Babies may be born in asphyxia or may be able to breathe but then experience asphyxia some time after birth. The purpose of this study was to determine the relationship between parity and old parturition with the incidence of asphyxia neonatorum in the pre-Sumatran city general hospital in 2019. This study uses an Analytical Survey using a Cross Sectional approach. The population of this research is the babies born in the prehumulih city general hospital in 2019 amounted to 1763 people. The number of samples in this study were 326 respondents. In the univariate analysis it was found that from 326 respondents it was found that parity of high risk mothers was 168 respondents (51.5%) while parity of low risk mothers was 158 respondents (48.5%) and mothers who were diagnosed with prolonged labor were 149 respondents (45.7 %) while mothers who were not diagnosed with prolonged labor were 177 respondents (54.3%). Bivariate analysis shows parity has a significant relationship with the incidence of asphyxia neonatorum (p value 0,000) and old parturition has a significant relationship with the incidence of asphyxia neonatorum (p value 0,000). The conclusion of this study is that there is a relationship between parity and old parturition with the incidence of asphyxia neonatorum.

Prediction of Perinatal Outcome with Meconium-stained Liquor

Background & objective: Passage of meconium in the amniotic fluid during labor has long been considered as fetal compromise resulting from fetal hypoxia or increased vagal activity from cord compression. It is also a sign of normal gastrointestinal tract maturation under neuronal control. However, presence of meconium in the amniotic fluid is traditionally viewed as unfavorable perinatal outcome. So, the present study was contemplated to find the association between grade of meconium during labor and perinatal outcome. Methods: The present prospective study was conducted in the North Bengal Medical College, Sirajganj between January 2016 – April 2017. Based on predefined criteria, 53 singleton pregnant women with meconium-stained liquor (MSL) on spontaneous or artificial rupture of membrane after 37 completed weeks of gestation were included in the study. Meconium-stained liquor was graded as “Thick” if the fluid was dark green in colour, viscous, tenacious, opalescent or opaque containing large amount of particulate materials and “Thin” if the fluid was translucent, light yellow green in colour without particulate material. The perinatal outcome was evaluated in terms of APGAR score of neonates at 1 and at 5 minutes of birth, NICU admission, resuscitation needed, jaundice and respiratory distress syndrome (RDS) due to meconium aspiration. Asphyxia neonatorum was diagnosed if APGAR at birth and/or at 5 minutes was < 7. All the outcomes were then compared between mothers forming ‘Thick’ and ‘Thin’ meconium cohort. Result: Of the 53 meconium-stained liquor, nearly half (49%) was with ‘Thick’ meconium and the half (51%) was with ‘Thin’ meconium. Approximately 85% of the neonates were delivered by lower uterine caesarean section (LUCS) and 80% of the neonates were asphyxiated at birth which reduced to 15.1% at 5 minutes. More than three-quarters (75.5%) of the neonates required resuscitation and 28.3% had respiratory distress syndrome (RDS). The incidences of asphyxia neonatorum, resuscitation needed and RDS were significantly higher in ‘Thick’ meconium cohort than those in ‘Thin’ meconium cohort with risks of having these conditions in the former cohort being 6(95% CI = 1.1–31.2), 4.5(95% CI = 1.1–18.9) and 4.2(95% CI = 1.1–15.7) times higher respectively than those in the latter cohort (p = 0.021, p = 0.031 and p = 0.026 respectively). Conclusion: Majority of the neonates born of mothers with thick meconium cohort are asphyxiated, need resuscitation and/or develop RDS. Asphyxia neonatorum, need for resuscitation and RDS are significantly higher in ‘Thick’ meconium cohort than those in ‘Thin’ meconium cohort with risks of having these conditions in the former cohort being several times higher than those in the latter cohort. Ibrahim Card Med J 2019; 9 (1&2): 67-73