Inactivation of SARS- CoV 2 from different items like vegetables, fruits, parcels, coins, masks, personal protection equipment, etc used in domestic, office and hospital purposes is now very essential work to break transmission of this pandemic virus. Washing of the purchased materials from markets, our hands and washing of other items by water or soap water have increased many folds. For this purpose, an innovative machine (2ft length, 1.5ft breadth and 1.5 ft height) has been designed by multimodal approaches. The approaches includes UVC (254 nm), heat and copper metal treatment for inactivation of SARS CoV2. Machine includes two cycles, one UVC cycle and another heat cycle to inactivate or kill virus. Both cycles can be operated at one time or separately one after another. In this machine four UVC tubes (each 15 W) were fitted in different angles to irradiate maximum UVC to the items distantly located in the cabinet of machine. The dose of UVC, time of the exposure and maximum distance of the item were standardized in such as way that 99.999% inactivation of SARS- CoV2 occurred within 30 to 40 min The maximum dose was 18,331 J/m2 of UVC in this cabinet. SARS CoV2 isolate multiplied in Vero-E6 cell line and treated by UVC cycle at the maximum distance 9 inch and heat cycle at 50 to 600C temperature separately for 30 to 40 min. Infectivity of treated virus was tested in Vero E6 cell line by TCID 50 assay and this assay has confirmed that this treated virus has no infection capacity. In conclusion, this designed cabinet must serve our society as proper decontamination or SARS CoV2 inactivation in pandemic situation to break the transmission chain of this virus and save our precious water.