Memory Binding Test and Its Associations With Hippocampal Volume Across the Cognitive Continuum Preceding Dementia

Innovative memory paradigms have been introduced to capture subtle memory changes in early Alzheimer’s disease (AD). We aimed to examine the associations between different indexes of the challenging Memory Binding Test (MBT) and hippocampal volume (HV) in a sample of individuals with subjective cognitive decline (SCD; n = 50), amnestic mild cognitive impairment (aMCI) due to AD ( n = 31), and cognitively normal (CN) older adults ( n = 29) recruited from the Czech Brain Aging Study, in contrast to traditional verbal memory tests. Both MBT free and cued recall scores in immediate and delayed recall conditions were associated with lower HV in both SCD and aMCI due to AD, whereas in traditional verbal memory tests only delayed recall scores were associated with lower HV. In SCD, the associations with lower HV in the immediate recall covered specific cued recall indexes only. In conclusion, the MBT is a promising test for detecting subtle hippocampal-associated memory decline during the predementia continuum.

Survey participation among general practitioners: comparison between teaching physicians and a random sample

Objective Health scientists strive for a smooth recruitment of physicians for research projects like surveys. Teaching physicians are an easy to approach population that is already affiliated with a university by teaching students in their practice. How do response rates compare between a convenient online survey among teaching physicians and an elaborate postal survey in a random sample of unknown physicians? Data from the TMI-GP study on the use of memory tests in general practice were used. Results Physicians in the random sample responded to the postal survey more often than teaching physicians to the online survey (59.5% vs. 18.9%; odds ratio 7.06; 95% confidence interval 4.81–10.37; p < 0.001). Although it is unclear whether the sample, the survey mode (online vs. postal) or both account for this effect, it is noteworthy that even in such a convenience sample of known/committed physicians, an adequate response rate could not be reached without a tailored and elaborated survey technique. Responders in the two samples were comparable regarding a content-related item (use of memory tests; Χ2 (df = 1) = 3.07; p = 0.080).

The Memory-Undermining Effect of Simulated Crime-Related Amnesia and Its Legal Implications: a Review

Pretending to suffer from amnesia for a mock crime has been shown to lead to memory impairments. Specifically, when people are asked to give up their role of simulators, they typically recall fewer crime-relevant details than those who initially confess to a crime. In the current review, we amassed all experimental work on this subject and assessed the characteristics of the memory-undermining effect of simulated amnesia for a crime procedure (i.e., crime stimuli, simulating amnesia instructions, memory tests, and memory outcomes). We specifically focused on the effect that crime-related amnesia claims may have on offenders’ final memory reports. Our review showed that simulators who initially claimed amnesia might paradoxically experience some sort of forgetting pertaining to crime-related information. This issue could likely lead to legal complications that need be taken into account in crime-related amnesia cases.

Hidden Objective Memory Deficits Behind Subjective Memory Complaints in Patients With Temporal Lobe Epilepsy

Objective:To test the hypothesis that temporal lobe epilepsy (TLE) patients with subjective initial memory complaints (not confirmed by an objective standard assessment) and various phenotypes also show objective very long-term memory deficit with accelerated long-term forgetting. We tested TLE patients with two surprise memory tests after three weeks: the standard Free and Cued Selective Reminding Test (FCSRT), and Epireal, a new test specifically designed to capture more ecological aspects of autobiographical memory.Methods:47 TLE patients (12 hippocampal sclerosis, 12 amygdala enlargement, 11 extensive lesions, 12 normal MRI) who complained about their memory, but for whom the standard neuropsychological assessment did not reveal any memory impairment after a standard delay of 20 minutes, underwent two surprise memory tests after three weeks. They were compared to 35 healthy control subjects.Results:After three weeks, FCSRT and Epireal recall scores were significantly lower in patients than in controls (p<0.001). There was no significant correlation between FCSRT and Epireal scores (p=0.99). Seventy-six percent of TLE patients had objective impairment on at least one of these very long-term memory tests, regardless of the existence and type of lesion or response to antiseizure medication. Easily applicable, Epireal had a higher effect size, detected deficits in 28% more patients, and is a useful addition to the standard workup.Conclusion:Assessing long-term memory should be broadened to a wide spectrum of TLE patients with a memory complaint, regardless of the epileptic syndrome, whether or not associated with a lesion. This could lead to rethinking TLE nosology associated with memory.

Deficits in central auditory processing among migraine patients

Background Migraine is a neurological disease associated with abnormal excitability in visual, somatosensory, and motor cortex. This study aimed to verify and compare auditory processing performance in migraine patients with and without dizziness and healthy controls. Results Sixty subjects were divided into 3 groups: control group, twenty normal healthy subjects, and study group I (twenty subjects diagnosed with migraine) and study group II (twenty subjects diagnosed with vestibular migraine). They were evaluated using the Central Auditory Processing Questionnaire for adults, tympanometry, pure tone audiometry, Psychophysical Central Auditory Tests, including Arabic Speech Intelligibility in Noise Test for adults, Arabic Dichotic Digit Test [version II], Gap in Noise Test, Duration Pattern Test, and Arabic Memory Tests. No significant difference was found between the two study groups I and II, but the significant difference was found between the study groups and the control group in all central auditory test results. Statistically significant difference was found between the control group and study groups I and II regarding all memory tests. The highest percentage of abnormality was present in temporal resolution and selective auditory attention in both study groups. There was no significant statistical correlation between the number of attacks/month and central auditory test results. There was no significant statistical correlation between the frequency of attacks in VM patients and central auditory test results. Conclusions Patients with migraine and vestibular migraine had an inferior performance in all psychophysical central auditory tests when compared with control. Also, there was no significant difference between the 2 study groups regarding central auditory test results which may support that both migraine with and without dizziness have the same pathophysiology.

Age effects in autobiographical memory depend on the measure

Studies examining age effects in autobiographical memory have produced inconsistent results. This study examined whether a set of typical autobiographical memory measures produced equivalent results in a single participant sample. Five memory tests (everyday memory, autobiographical memory from the past year, autobiographical memory from age 11–17, word-cued autobiographical memory, and word-list recall) were administered in a single sample of young and older adults. There was significant variance in the tests’ sensitivity to age: word-cued autobiographical memory produced the largest deficit in older adults, similar in magnitude to word-list recall. In contrast, older adults performed comparatively well on the other measures. The pattern of findings was broadly consistent with the results of previous investigations, suggesting that (1) the results of the different AM tasks are reliable, and (2) variable age effects in the autobiographical memory literature are at least partly due to the use of different tasks, which cannot be considered interchangeable measures of autobiographical memory ability. The results are also consistent with recent work dissociating measures of specificity and detail in autobiographical memory, and suggest that specificity is particularly sensitive to ageing. In contrast, detail is less sensitive to ageing, but is influenced by retention interval and event type. The extent to which retention interval and event type interact with age remains unclear; further research using specially designed autobiographical memory tasks could resolve this issue.

Involvement Modulates the Effects of Deception on Memory in Daily Life

Previous studies have demonstrated that liars who adopt a false denial strategy often forget what they lied about, which has been labeled the denial-induced forgetting (DIF) effect. However, several investigations have not found such an effect. It has been suggested that involvement might play a role in the inconsistency. The present study was designed to directly determine whether involvement modulates the effects of deception on memory. Participants were assigned randomly to either high- or low-involvement conditions and were required to complete a mock shopping task. They were then asked to participate in an interview in which they were asked to respond honestly or deceptively. Two days later, final memory tests were given, and the participants were asked to give honest responses. We found a DIF effect in the high-involvement condition but not in the low-involvement condition. Moreover, the liars in the high-involvement condition created more non-believed memories in the source memory test and the destination memory test than the honest participants. In addition, liars in both the high- and low-involvement conditions forgot who they lied to. We conclude that the effects of deception on memory could be influenced by the degree of involvement.