Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults

Objective Recent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene (FTO) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated FTO rs1421085 association with body mass index (BMI), macronutrient intake, and fatty acid intake. The association was evaluated using linear regression analyses assuming co-dominant, dominant, recessive, over-dominant, and additive genetic models. Results Only individuals with the CC genotype had a considerably higher BMI (p < 0.001), which indicates a recessive genetic trait, but the incidence for this genotype is low (68 TT + TC vs. 3 CC). Individuals with the minor C allele had an estimated increase of fat intake by 3.45–4.06% across various genetic models (dominant: p < 0.010, over-dominant: p < 0.030, additive: p < 0.010). Subjects with TC/CC genotypes had increased dietary monounsaturated fatty acid (MUFA; 1.14%, p = 0.046) and saturated fatty acid (SAFA; 2.06%, p = 0.023) intakes, compared to those with the TT genotype. In conclusion, our study provided evidence for the association between FTO rs1421085 risk allele with higher BMI and individual preferences for consuming more fat, MUFA, and SAFA. This study highlights the important role of FTO gene in food preference, and its influence on body weight.

A Clinical Analysis of the Medicolegal Cases Presented at Khawaja Muhammad Safdar Medical College, Sialkot

Objective: To determine the clinical pattern of the medicolegal cases presented at Khawaja Muhammad Safdar Medical College, Sialkot Material and Methods: It was a retrospective Hospital based cross-sectional study, which was conducted at medicolegal clinic of government Khawaja Muhammad Safdar Medical College, Sialkot. All the cases those, who were presented at emergency department (medicolegal clinic) with history of industrial injuries, Road traffic accidents, burns, Assault, Falls and Poisoning and others with either of age and gender were included. This analysis was of one year from January 2020 to December 2020. All the data was recorded via self-made study proforma and analyzed by using SPSS version 20. Results: A total of 1079 medicolegal incidents were analysed. Out of all blunt injury, sharp weapon injury, poisoning, acid intake and road traffic incidences were found to be commonest as 27.20%, 20.60%, 15.60%, 12.40% and 10.20% respectively. Blunt injuries, sharp weapon injuries, gunshot injuries and alcohol intake incidences were significantly higher among males and poisoning and acid intake incidences were significantly high among females (p-<0.05). Blunt injuries, sharp weapon injuries, alcohol and poisoning events were seen significantly high almost during winter season from January to march (p-0.001). Conclusion: In the study conclusion, blunt injury, sharp weapon injury, poisoning, acid intake and road traffic incidences were observed to be the commonest medicolegal incidences. These events mostly observed during January to March duration. However blunt injuries, sharp weapon injuries, gunshot injuries and alcohol intake incidences were mostly observed among males, while poisoning and acid intake incidences among females. Keywords: Medicolegal events, gender, season

Total Fat and Fatty Acid Intake among 1–7-Year-Old Children from 33 Countries: Comparison with International Recommendations

This work reviews available data on dietary intakes of total fat, saturated fatty acids (SFA) and individual polyunsaturated fatty acids (PUFA) in children in different countries worldwide and for the first time, compares them with recent international recommendations. Studies published before June 2021 reporting total fat, total SFA and individual PUFA intakes in children aged 1–7 y were included. Observed intakes were evaluated against FAO/WHO and EFSA recommendations. 65 studies from 33 countries were included. Fat intake was too low in 88% of studies in young children (1–3 y). SFA intake was >10%E in 69–73% of children, especially in Europe. Linoleic acid intake was <3%E in 24% of studies in 1–2 y olds and within FAO/WHO recommendations among all other ages. Alpha-linolenic acid intake was <0.5%E in almost half of studies. Docosahexaenoic acid (DHA) or eicosapentaenoic acid + DHA intakes were below recommendations in most studies. In summary, while total fat intake was too low among younger children, SFA intake was above, especially in Europe and n-3 PUFA intake, especially DHA, were below recommendations for all ages. Intake of n-3 PUFA, especially DHA, is generally suboptimal. More data, particularly from developing countries, are required to refine these findings and guide implementation of adapted nutrition policies.

169Folic acid intake and dementia - a 27-year global longitudinal study

Background Folate deficiency increases serum homocysteine and may cause cognitive impairment. However, there have been no international longitudinal studies that examined the association between folic acid intake and dementia. We investigated the longitudinal association between folate intake and the prevalence of dementia using global data during 27 years. Methods Prevalence of Alzheimer’s disease and other dementias and folic acid intake by country were obtained from the Global Burden of Disease (GBD) 2017 database. The longitudinal associations between folic acid intake and prevalence of dementia was examined using linear mixed effect model during 27 years from 1990 to 2017 in 151countries with populations of 1 million or greater. The effects of folic acid, year and interaction of folic acid and year were estimated controlling for covariates including socio-economic variables and life-style variables. Results Fixed effects of folic acid was highly significant (mean and SE; -33.1±7.1, p &lt; 0.001) and interaction of folic acid and survey year was also significant (0.90±0.13, p &lt; 0.001). Slope of folic acid for dementia prevalence was significant in 1990 and the slope has decreased with the year and has become not significant after 2011. Conclusions Folic acid was associated with the prevalence of dementia, but weakened over the years. Key messages Although folic acid intake has been associated with the of dementia, the risk of dementia may be increasingly related to factors other than nutrition.