Resting-State Functional Connectivity Associated With Extraversion and Agreeableness in Adolescence

Although adolescence is a period in which developmental changes occur in brain connectivity, personality formation, and peer interaction, few studies have examined the neural correlates of personality dimensions related to social behavior within adolescent samples. The current study aims to investigate whether adolescents’ brain functional connectivity is associated with extraversion and agreeableness, personality dimensions linked to peer acceptance, social network size, and friendship quality. Considering sex-variant neural maturation in adolescence, we also examined sex-specific associations between personality and functional connectivity. Using resting-state functional magnetic resonance imaging (fMRI) data from a community sample of 70 adolescents aged 12–15, we examined associations between self-reported extraversion and agreeableness and seed-to-whole brain connectivity with the amygdala as a seed region of interest. Then, using 415 brain regions that correspond to 8 major brain networks and subcortex, we explored neural connectivity within brain networks and across the whole-brain. We conducted group-level multiple regression analyses with the regressors of extraversion, agreeableness, and their interactions with sex. Results demonstrated that amygdala connectivity with the postcentral gyrus, middle temporal gyrus, and the temporal pole is positively associated with extraversion in girls and negatively associated with extraversion in boys. Agreeableness was positively associated with amygdala connectivity with the middle occipital cortex and superior parietal cortex, in the same direction for boys and girls. Results of the whole-brain connectivity analysis revealed that the connectivity of the postcentral gyrus, located in the dorsal attention network, with regions in default mode network (DMN), salience/ventral attention network, and control network (CON) was associated with extraversion, with most connections showing positive associations in girls and negative associations in boys. For agreeableness, results of the within-network connectivity analysis showed that connections within the limbic network were positively associated with agreeableness in boys while negatively associated with or not associated with agreeableness in girls. Results suggest that intrinsic functional connectivity may contribute to adolescents’ individual differences in extraversion and agreeableness and highlights sex-specific neural connectivity patterns associated with the two personality dimensions. This study deepens our understanding of the neurobiological correlates of adolescent personality that may lead to different developmental trajectories of social experience.

Tractography of White Matter Fibers Using Diffusion MRI

To understand more about the human brain and how it works, it is vital to understand how the neural circuits connect different regions of the brain. The human brain is filled predominantly with water and the majority of the water molecules undergo diffusion which can be captured with the help of diffusion MRI. Diffusion weighted images enable us to reconstruct the neural circuits in a non-invasive manner, and this procedure is referred to as tractography. Tractography aids neurosurgeons to understand the neural connectivity of the patient. This chapter attempts to explain the procedure of tractography and different types of algorithms.

Opioid antagonism modulates wanting-related frontostriatal connectivity

Theoretical accounts distinguish between motivational ('wanting') and hedonic ('liking') dimensions of rewards. Previous animal and human research linked wanting and liking to anatomically and neurochemically distinct brain mechanisms, but it remains unknown how the different brain regions and neurotransmitter systems interact in processing distinct reward dimensions. Here, we assessed how pharmacological manipulations of opioid and dopamine receptor activation modulate the neural processing of wanting and liking in humans in a randomized, placebo-controlled, double-blind clinical trial. Reducing opioid receptor activation with naltrexone selectively reduced wanting of rewards, which on a neural level was reflected by stronger coupling between dorsolateral prefrontal cortex and the striatum under naltrexone compared with placebo. In contrast, reducing dopaminergic neurotransmission with amisulpride revealed no robust effects on behavior or neural activity. Our findings thus provide insights into how opioid receptors mediate neural connectivity related to specifically motivational, not hedonic, aspects of rewards.

A novel approach to understanding Parkinsonian cognitive decline using minimum spanning trees, edge cutting, and magnetoencephalography

Graph theory-based approaches are efficient tools for detecting clustering and group-wise differences in high-dimensional data across a wide range of fields, such as gene expression analysis and neural connectivity. Here, we examine data from a cross-sectional, resting-state magnetoencephalography study of 89 Parkinson’s disease patients, and use minimum-spanning tree (MST) methods to relate severity of Parkinsonian cognitive impairment to neural connectivity changes. In particular, we implement the two-sample multivariate-runs test of Friedman and Rafsky (Ann Stat 7(4):697–717, 1979) and find it to be a powerful paradigm for distinguishing highly significant deviations from the null distribution in high-dimensional data. We also generalize this test for use with greater than two classes, and show its ability to localize significance to particular sub-classes. We observe multiple indications of altered connectivity in Parkinsonian dementia that may be of future use in diagnosis and prediction.

Increased Connectivity of Thalamocortical Tract/Occipital Cortex Concurrent with Recovery of Impaired Consciousness in a Stroke Patient: A Diffusion Tensor Tractography Study: A Case Report

Background: Little has been reported about the role of the occipital cortex in the recovery from impaired consciousness. In this case report, we report on a stroke patient who showed increased connectivity of the thalamocortical tract (TCT), including the occipital cortex, on follow-up diffusion tensor tractography (DTT) that was concurrent with recovery of impaired consciousness. Case presentation: A 64-year-old male patient underwent craniectomy and hematoma removal for spontaneous intracerebral hemorrhage (ICH) in the left fronto-parieto-temporal lobes and extraventricular catheterization for intraventricular hemorrhage (IVH). When he started rehabilitation eight weeks after onset, he was in a minimally conscious state with a Coma Recovery Scale-Revised (CRS-R) score of 14. On 8-week DTT, decreased connectivity of the TCT between the thalamic intralaminar nuclei and the cerebral cortex was observed in both medial prefrontal cortices (mPFCs), the occipital cortex, and the left parietal cortex. By contrast, on 12-week DTT, TCT connectivity had increased to include both medial prefrontal cortices and the right occipital cortex. Conclusion: Increased neural connectivity of the TCT to the mPFC and the occipital cortex, as shown by DTT, contributed to the recovery of impaired consciousness in a stroke patient. The results suggest that increased neural connectivity to the occipital cortex might contribute to the recovery of impaired consciousness in stroke patients.