As of today, the principle of zero-waste production is not only a global trend, but also an effective mechanism for protecting and preserving the environment, as well as making fuller use of the resource potential of enterprises. The main idea of zero-waste manufacturing is the transformation of raw materials received by the enterprise, its residues, as well as waste obtained in the production process, into finished products that can generate income. In this regard, modern companies are making the transition from a linear to a circular economy in order to preserve the ecosystems of our planet. This transition is characterized by waste-free production as well as maximum use of raw materials and production capacity. Such an important step will not only save our planet and ultimately ourselves, but will also bring in the profits that companies simply lose by destroying waste. Ukraine lags far behind European countries in the field of waste management, and the volume of waste generated, the state of landfills and dumps indicate extreme risks to the environment and the population. Inefficient waste management in Ukraine is, in particular, a consequence of the existing linear economic model. Thus, the issue of developing zero-waste technologies and effective implementation of zero-waste manufacturing at Ukrainian enterprises, in particular with the involvement of European experience, becomes extremely important. Accordingly, the article analyzes the essence, key principles and principles of zero-waste manufacturing in the domestic and European areas in order to adopt the best experience of the EU, which is currently a leader in this aspect in the world. The key aspects, principles and features of zero-waste manufacturing were analyzed, as well as successful European and domestic practices of its application were demonstrated. These findings will be useful for individual domestic enterprises, industries, the country and civil society as a whole.