Meta-Analysis of the Correlation between TCM Syndromes of Lung Cancer and CT through Data Mining and Computer Software

To systematically evaluate the correlation between the traditional Chinese medicine (TCM) syndromes of lung cancer and the imaging manifestations of CT. Computer search of CNKI, Cochrane Library, PubMed, Springer, CBM, VIP, Wanfang database, Baidu library and other major databases. Collect the relevant literature on the TCM syndromes of lung cancer and CT imaging manifestation since the database was built until September 1, 2021. Two researchers collected literature and evaluated the quality of the literature, conducted data mining on the literature, and used the computer Revman 5.3 software to conduct a Meta-analysis of the included literature. The results showed that the phlegm dampness type lobular sign was higher than the burr sign, and there was no significant difference between vacuole sign and cavity sign; In Qi-Yin deficiency type, lobular sign was higher than burr sign, vacuole sign was higher than cavity sign; In Qi stagnation blood stasis type, lobular sign is higher than burr sign. The CT lobular sign of lung cancer are mainly phlegm dampness type, Qi-Yin deficiency type and Qi stagnation blood stasis type. Vacuole sign is mainly Qi-Yin deficiency type. Burr sign and cavity sign are less in the above three types. In this study, the combination of computer and meta-analysis technology has promoted the development of lung cancer micro-differentiation theory and assisted in improving the treatment level of lung cancer clinical syndrome differentiation.

Chief Physician Wang Defen’s Experience in Treating Thyroid Nodules based on Syndrome Differentiation

To summarize the experience of Chief Physician Wang Defen in the treatment of thyroid nodules. According to many years of clinical experience, Chief Physician Wang Defen believes that the occurrence of thyroid nodules is mostly affected by emotional factors. Qi stagnation, liver depression and fire, phlegm and Qi are the pathogenesis of the disease, which is closely related to liver Qi stagnation. Based on the basic treatment principle of Nourishing Yin, clearing heat, soothing liver and strengthening spleen, the prescription chose Danzhi Xiaoyao Powder plus or minus can often achieve good clinical efficacy.

Exploring biological basis of Syndrome differentiation in coronary heart disease patients with two distinct Syndromes by integrated multi-omics and network pharmacology strategy

Background Traditional Chinese Medicine (TCM) is distinguished by Syndrome differentiation, which prescribes various formulae for different Syndromes of same disease. This study aims to investigate the underlying mechanism. Methods Using a strategy which integrated proteomics, metabolomics study for clinic samples and network pharmacology for six classic TCM formulae, we systemically explored the biological basis of TCM Syndrome differentiation for two typical Syndromes of CHD: Cold Congealing and Qi Stagnation (CCQS), and Qi Stagnation and Blood Stasis (QSBS). Results Our study revealed that CHD patients with CCQS Syndrome were characterized with alteration in pantothenate and CoA biosynthesis, while more extensively altered pathways including D-glutamine and D-glutamate metabolism; alanine, aspartate and glutamate metabolism, and glyoxylate and dicarboxylate metabolism, were present in QSBS patients. Furthermore, our results suggested that the down-expressed PON1 and ADIPOQ might be potential biomarkers for CCQS Syndrome, while the down-expressed APOE and APOA1 for QSBS Syndrome in CHD patients. In addition, network pharmacology and integrated analysis indicated possible comorbidity differences between the two Syndromes, that is, CCQS or QSBS Syndrome was strongly linked to diabetes or ischemic stroke, respectively, which is consistent with the complication disparity between the enrolled patients with two different Syndromes. These results confirmed our assumption that the molecules and biological processes regulated by the Syndrome-specific formulae could be associated with dysfunctional objects caused by the Syndrome of the disease. Conclusion This study provided evidence-based strategy for exploring the biological basis of Syndrome differentiation in TCM, which sheds light on the translation of TCM theory in the practice of precision medicine.

Collection of Professor Lihong Zhu’s Experience in Treating Postpartum Hypogalactia of Blood Deficiency and Liver Depression Type

Professor Lihong Zhu proposed the syndrome type of “blood deficiency and liver depression” in the clinical treatment of postpartum hypogalactia, and discussed its main etiology and pathogenesis as Yin blood deficiency and liver Qi stagnation, with blood deficiency as the basis and liver depression as the standard. She self-made “Shugan Shengru prescription,” which was added and subtracted with symptoms, with remarkable clinical effect, and widened the thinking of diagnosis and treatment of postpartum hypogalactia.

Association of Qi-stagnation and Subjective Sleep Characteristics with Mild Cognitive Impairment Among Non-depressed Elderly in Community: A Cross-Sectional Study

Objective: Depression and sleep disturbance is commonly reported in patients with mild cognitive impairment (MCI). However, it remains unclear whether Qi-stagnation is still a risk factor for MCI before the older adults suffer from depression. The purpose of this study was to examine the association between Qi-stagnation and subjective sleep quality with MCI among non-depressed elderly in the Chinese community.Methods: A simple random sampling method was used to abstract research subjects from 34 community elderly day care centers in Fuzhou city based on their electronic health records from March 2019 to December 2020. Intensive face-to-face interviews were conducted using tools such as Montreal cognitive function assessment, AD8 dementia screening questionnaire, Pittsburgh Sleep Quality Index, and TCM constitution assessment scale, among others to analyze the proportion of older adults with MCI who suffer from sleep disturbance and Qi-stagnation in the community. Multi-factor logistical regression was employed to analyze the association among subjective sleep quality, TCM constitution, and MCI.Results: A total of 1,268 subjects were investigated and 1,071 cases were included in this study, among which 314 cases were of MCI patients, with a morbidity of 29.3%. The proportion of individuals having Qi-deficiency (12.4%) and Qi-stagnation (11.1%) was higher in MCI patients than in the controls with normal cognitive function (P<0.05). After adjusting for age, gender, and years of education, the probability of the old with Qi-deficiency and Qi-stagnation suffering from MCI was 1.559 times [95% confidence interval (CI): 1.009–2.407] and 1.706 times (95% CI: 1.078–2.700) higher than that of the older adults without Qi-deficiency and Qi-stagnation, respectively. In the Pittsburgh sleep quality index (PSQI) scale, individuals with MCI had poorer subjective sleep quality (Z=-3.404, P=0.001), longer sleep latency (Z=-3.398, P=0.001), shorter sleep duration (Z=-2.237, P=0.025), and aggravated daytime dysfunction (Z=-3.723, P<0.001) compared with those without MCI. The intergroup differences showed no statistical significance in the three dimensions including habitual sleep efficiency, sleep disturbance, and hypnotics between groups. The results of multi-factor logistical regression showed that sleep latency [odds ratio (OR)=1.168, 95% CI: 1.016–1.342], daytime dysfunction (OR=1.261, 95% CI: 1.087–1.463), and Qi-stagnation (OR=1.449, 95% CI: 1.022–2.055) were the risk factors for MCI; the OR for older adults with sleep disturbance and Qi-stagnation suffering from MCI was 2.581 (95% CI 1.706–3.907).Conclusion: MCI patients have a higher incidence of sleep disorders and Qi-stagnation, and may show specific changes in their daytime and nighttime sleep characteristics, with the specific manifestations such as difficulty in falling asleep, easily waking up at night/ early morning, and daytime dysfunction, among others.

Study of Scraping with Copper Stone Based on Theory of Midnight-Noon Ebb-Flow in Angina Pectoris with Coronary Heart Disease of Qi Stagnation and Blood Stasis

Angina pectoris (AP) with coronary heart disease (CHD) is one of the common cardiovascular diseases in clinical practice, which can be classified as “chest paralysis” in Chinese medicine according to its symptoms, and it is described in many ancient documents. Ancient Chinese medicine believes that the main pathogenesis of the disease is poor blood flow leading to paralysis of the heart and veins, so it is often treated by activating blood and removing blood stasis. In this study, 120 patients with AP of CHD of Qi stagnation and blood stasis type were randomly divided into the observation (n = 60) and the control group (n = 60). In the control group, basic care, conventional treatment, and unselected copper acupuncture scraping were used, while in the observation group, copper acupuncture scraping was performed at the right time of the heart meridian (11 : 00–13 : 00) on the basis of the control group, and all patients received the treatment for a total duration of 4 weeks. We collected data on the traditional Chinese medical (TCM) syndrome score, frequency and duration of angina attacks, nitroglycerin dosage, inflammatory factor levels, and hematological indices pretreatment and posttreatment in both groups. Patients’ adverse effects during treatment were recorded, and the clinical efficacy and ECG efficacy in both groups were evaluated after 4 weeks. We used SPSS.20 statistical software to statistically analyze the above data, and the results showed that the clinical efficacy and ECG efficacy of the observation group were significantly higher than the control group posttreatment. After treatment, the TCM symptom score, angina attack frequency, attack duration and nitroglycerin dosage, serum interleukin-8 (IL-8), hypersensitive C-reactive protein (hs-CRP), and tumor necrosis factor-α (TNF-α) levels, whole blood viscosity (WBV), plasma viscosity (PV), fibrinogen (FIB), and hematocrit (Hct) were significantly lower in both groups compared with those posttreatment. And the observation group showed a greater decrease when compared with the control group. The results also showed that the overall incidence of adverse reactions was lower in both groups during the treatment period. The above results indicate that while ensuring high safety, the copper stone based on theory of midnight-noon ebb-flow can more effectively improve the symptoms and inflammatory response of the body and reduce the viscosity of the blood in AP with CHD of Qi stagnation and blood stasis, and it has better therapeutic effects.

Efficacy and safety of Suxiao Jiuxin Pill in the treatment of stable angina (Qi stagnation and blood stasis syndrome): study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial

Background Coronary heart disease (CHD) has become one of the biggest health problems in the world. Stable angina is a common clinical type of CHD with poor prognosis and high mortality. Although there are various interventions for stable angina, none of them can significantly reduce mortality. Both basic and clinical research have shown that Suxiao Jiuxin Pill (SJP) can relieve the symptoms of angina pectoris and improve the clinical efficacy, but there is a lack of high-quality clinical research to provide research-based evidence. We design a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of SJP for stable angina. Methods/design This is a prospective, randomized, double-blind, placebo-controlled, and multicenter trial. The trial will enroll 324 participants with chronic stable angina (Qi Stagnation and Blood Stasis syndrome). All participants will have received the conventional therapy of chronic stable angina. Participants will be randomized into two groups, conventional therapy plus SJP group and conventional therapy plus placebo group. Eligible participants will receive either SJP or placebo (five pills administered orally, three times daily) in addition to conventional treatment for 24 weeks. The primary outcomes are the symptom improvement rate of angina from baseline to 4 weeks after inclusion and major adverse cardiovascular events (MACE). The secondary outcomes are angina classification (CCS), improvement of traditional Chinese medicine (TCM) syndromes, Seattle Angina Scale score, the dosage of emergency drugs and the stopping rate, and electrocardiogram (EKG) efficacy. Adverse events will be monitored throughout the trial. Discussion Integrated traditional Chinese and Western Medicine is commonly used for angina in China. This study will evaluate the clinical effectiveness and safety of SJP for angina. The results of the trial will provide high-level clinical research-based evidence for the application of SJP instable angina. Trial registration This study protocol was registered on 14 March 2019. The registration number is ChiCTR1900021876 on the Chinese Clinical Trial Registry.

Application of Multigroup Technology in Non-Small-Cell Lung Cancer with Qi Stagnation and Blood Stasis Syndrome

Objective. To explore the basic characteristics of intestinal flora, metabolomics, and proteomics of non-small cell lung cancer (NSCLC) in patients with Qi stagnation and blood stasis syndrome. Methods. Twelve NSCLC patients with Qi stagnation and blood stasis syndrome were selected for the QZXY group and 15 healthy volunteers were selected for the control group. Fecal samples from the two groups were collected to evaluate intestinal microecology using the 16s rDNA technique. Serum samples were collected to compare the differences in metabolomics and proteomics between the two groups using liquid chromatography-mass spectrometry (LC-MS). Another 34 NSCLC patients with other syndromes were selected for the nQZXY group and their serum samples were collected. Metabolomics differences between the QZXY and nQZXY groups were compared using LC-MS, and four metabolites with the most obvious differences were selected for receiver operation characteristic curve representation. Finally, multigroup results were analyzed using the WGCNA software. Results. There were two significantly different types of bacteria (Aerococcaceae and Abiotrophia), 11 different proteins (six upregulated and five downregulated), and 38 different metabolites (nine upregulated, 29 downregulated) between the QZXY and control groups. There was a correlation between differential bacteria, proteins, and metabolites. The conjoint analysis found that the different substances were related to MAPK, PI3K/Akt, Ras signaling pathway, cancer pathways, and cytokine-cytokine receptor interaction. There were four significant differences in metabolites (Pseudouridine, phenlacetyl-C0A, L-glutamic, and phospho-anandamide) between the QZXY and nQZXY groups. Conclusions. NSCLC with Qi stagnation and blood stasis syndrome had specific intestinal flora and protein and metabolites, which were closely related to the occurrence and development of tumors.

Ameliorative Effects of Component Chinese Medicine From Curcumae Rhizoma and Sparganii Rhizoma, a Traditional Herb Pair, on Uterine Leiomyoma in a Rat Model

Uterine leiomyoma (UL), common benign tumors in women of child-bearing age, are believed to be caused mainly by Qi stagnation and blood stasis, according to a theory of traditional Chinese medicine. Curcumae Rhizoma and Sparganii Rhizoma (CRSR) is a classical herb pair that activates blood circulation to dissipate blood stasis. The purpose of this study was to explore the prevention and treatment effects of CRSR component compatibility on UL in rats. We randomly assigned adult female non-pregnant rats into three groups: a normal control (NC) group, a UL model group, and a CRSR treatment group. We administered to the UL and CRSR groups oral gavage diethylstilbestrol and injected them with progesterone (P) to establish UL for 5 weeks. The CRSR group received a CRSR medicinal solution after daily modeling. The uterus morphology of the UL group showed significantly more swelling than did that of the NC group, and we found no significant abnormalities in the morphology of the CRSR group. The pathological changes associated with UL were relieved in the CRSR group. CRSR improved the related parameters of the uterus and ovarian coefficients, significantly reducing the concentrations of P in the serum and the concentrations of estradiol, P, estrogen receptor, and P receptor in the uterus and ovary. In addition, CRSR significantly improved the abnormal blood conditions of UL, shown by decreases in plasma viscosity, the erythrocyte sedimentation rate equation K value, and erythrocyte aggregation index. Therefore, CRSR component compatibility may prevent and cure UL through the above ways.