The Ocular drug delivery system (ODDS) is the prominently challenging system faced by pharmaceutical researchers. Ophthalmic
preparations are available in buffered, sterile and isotonic solutions. For the ocular delivery of drugs, various types of dosage forms
are prepared and dispensed. As the drops are easier for the administration likewise more prescribed dosage form is the eye drop
solution. For obtaining prolonged therapeutic effect ointment, suspensions and gelled systems are also used. The presence of various
barriers as anatomical, physiological and physiochemical barriers makes difficulties in delivery of drugs in at the intended sites.
Scientists invented alternate delivery routes to direct access at intended target sites. Second invention involves development of novel
drug delivery systems providing better permeability, treatability and controlled release at target site. The liposomal delivery is
beneficial because they have the ability of envelopment and both hydrophobic and hydrophilic drugs are suitable for delivery to both
the anterior and posterior segment of the eye. Therefore, the uses of this alternative approach become quite a necessary. This
formulation of novel devices will definitely help to the overcome ocular barriers and side effects with conventional topical drops.
Current reviews on the conventional formulations of ocular delivery and their advancements followed by current nanotechnology
based on the formulation developments. The recent incident with other ocular drug delivery planning consists of in situ gels, implants,
contact lens and nano wafers are discussed. Drug delivery at ophthalmic route has been proven significant advancement for the
future perspectives.