The liver is the key organ for maintaining the body’s internal environment and it plays a very significant role in the metabolism of various compounds like carbohydrate, proteins and fats, it also controls the flow of nutrients, it's maintaining body authenticity. It is useful in, dispose of exogenous toxins or beneficial agent, biochemical reaction. As its performances the numerous functions it has more risk for hepatotoxicity. The hepatotoxicity is generally created due to chemicals like artificial chemical includes CCl4, Galactosamine, Lithocholic acid and Anti-TB drugs, apart from artificial some Natural like microcystins and Herbal remedies such as Cascara Sagrada can also induce hepatotoxicity. In this, we provide the information regarding various plants and their extract studies for the protective effect on the liver against hepatotoxicity along with their specified isolated compounds like colchicine, kolaviron,indigtona,rubiadin, baicalin,wogonin, punicalin, for their hepatoprotective activity Keywords: Hepatoprotective, liver disease, Hepatocytes