Student game design and play represent a powerful means for encouraging advanced interactivity, development of critical thinking, and deeper learning in the classroom. Orchestrating the details, milestones, examples, and teams in the online setting can be challenging. Through clearly presented game models, tight integration with course content, and class coordination created specifically for design teams, the Game Design Methodology (GDM) provides a solid framework for teachers and learners to progress through the game making process and successfully achieve course outcomes. Through the use of case studies, this book chapter will outline the tools, techniques, and performance outcomes that instructors need to plan, implement, and facilitate the use of GDM in their online classes.