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OCL ◽  
2022 ◽  
Vol 29 ◽  
pp. 1
Author(s):  
Camille Dumont

Therapeutic peptides can treat a wide variety of diseases with selective and potent action. Their oral bioavailability is strongly limited by an important proteolytic activity in the intestinal lumen and poor permeation across the intestinal border. We have evaluated the capacity of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) to overcome both oral bioavailability limiting aspects, using leuprolide (LEU) as model peptide. Lipidization of LEU by formation of a hydrophobic ion pair (HIP) with sodium docusate enables a significant increase of peptide encapsulation efficiency in both SLN and NLC. The nanocarriers, obtained by high-pressure homogenization, measured 120 nm and were platelet shaped. Regarding the protective effect towards proteolytic degradation, only NLC maintained LEU integrity in presence of trypsin. Intestinal transport, evaluated on Caco-2 (enterocyte-like model) and Caco-2/HT29-MTX (mucin-secreting model) monolayers, showed nanocarriers internalization by enterocytes but no improvement of LEU permeability. Indeed, the combination of nanoparticles platelet-shape with the poor stability of the HIP in the transport medium induces a high burst release of the peptide, limiting nanoparticles capacity to transport LEU across the intestinal border. Stability of peptide lipidization needs to be improved to withstand biorelevant medium to benefit from the advantages of encapsulation in solid lipid nanocarriers and consequently improve their oral bioavailability.


OCL ◽  
2022 ◽  
Vol 29 ◽  
pp. 6
Author(s):  
Patrick Carré

In a context where the search for naturalness, the need to reduce the carbon footprint and the development of a decentralized crushing sector are intensifying, mechanical extraction is a technology that is regaining major importance for the industry. The performance of this technique remains far below what is desirable, while the understanding of the main phenomena involved in screw presses remains insufficient. This article, after a brief presentation of the state of the art of this discipline, presents a new model centered on the notions of pressure generation and plasticity. According to this approach, plasticity can account for parameters such as the water and oil content of oilseeds, their temperature, and their possible dehulling. Plasticity in turn would explain both the compressibility of the cake and its ability to resist the thrust of the screws, and consequently to generate pressure or to creep or flow backward depending on the geometry of the screw and the cage. The model must also incorporate the notions of compression velocity, friction, and the complexity of the interactions between these parameters and the impact of the succession of screw segments and cone rings. It has been built on observation and experience and gives an understanding of the need to work simultaneously on the conditioning and geometry of the presses to achieve improved performance in terms of energy, efficiency, and reduction of the temperatures experienced by the proteins and oils


OCL ◽  
2022 ◽  
Vol 29 ◽  
pp. 5
Author(s):  
Meriem Tekaya ◽  
Mguidich Belhaj Amel ◽  
Beligh Mechri ◽  
Mohamed Ayadi ◽  
Manel Ben Slamia Aouina ◽  
...  

Blends of olive oils obtained from four cultivars (Olea europaea L. cv. Chemlali, Chetoui, Oueslati and Koroneiki) were produced by two different methods of blending: processing fruit mixtures or mixing monovarietal oils, using the same proportions of selected cultivars. The obtained blends were biochemically characterized to evaluate quality, and the two methods were compared. The results indicated that the most successful formulations are mainly F8 (60% Chemlali × 20% Oueslati × 20% Koroneiki) characterized by the highest contents of phenols and an elevated oxidative stability, and F5 (50% Chemlali × 50% Koroneiki) containing the highest MUFA level and the highest oxidative stability. The effect of the blending process on pigments and volatiles cannot be easily regulated, unlike phenols, fatty acid composition and OS, all of which positively correlated to the fruit mass ratio in the blend. Results suggest that processing fruit mixtures of different cultivars resulted in a better oil quality than that of oils obtained by the common oil blending method. This blending procedure offers a possibility to modulate the contents of antioxidants, fatty acids and volatile compounds in virgin olive oil, and therefore, its quality and sensorial characteristics.


OCL ◽  
2022 ◽  
Vol 29 ◽  
pp. 4
Author(s):  
Cécile Le Gall ◽  
Vincent Lecomte ◽  
Dominique Wagner

The development of organic agriculture in France was steady since 2010 but became stronger since 2014. Like other crops, the cultivated areas of organic soybean and sunflower doubled from 2014 to 2018. With a view to better characterize cultural practices in organic production, Terres Inovia and ITAB (in collaboration with Agence Bio) conducted in 2016 and 2017 a national farmers’ survey. These surveys reveal that sunflower was mainly cultivated over the same types of soil than in conventional production but were integrated in more diversified rotations. The main differences between organic and conventional systems concern sowing date and weed control. Organic sunflower was sown very lately compared to conventional one, which impacted the yield severely. Weed were controlled through ploughing, mechanical weeding and crop rotation and weed control was judged as satisfying by a major part of producers. Concerning soybean, a great difference is the use of irrigation which is almost systematic in conventional but concerned only 50% of cultivated area in organic production. Contrary to sunflower, soybean is integrated in short crop rotation, particularly when it was irrigated. This demonstrated the high profitability of soybean in organic systems. Like for sunflower, weed control done through ploughing, mechanical weeding, and crop rotation and weed control was also judged satisfying; nevertheless, criteria on harvest impurities are more severe and to respect them, organic farmers also use hand weeding in complement. These surveys will be reconducted over the years to be able to follow the changes of cultural practices over the years.


OCL ◽  
2022 ◽  
Vol 29 ◽  
pp. 2
Author(s):  
Elina Hishamuddin ◽  
Mei Huey Saw

Incorporation of oils from non-conventional sources into palm olein through the blending process generates a sustainable source of novel oleins with improved physicochemical and functional properties. The objective of this study was to evaluate the effects of blending winged bean (Psophocarpus tetragonolobus) seed oil (WBSO) and palm olein (POo) on the physicochemical properties of the blends. Blends of WBSO (25, 50 and 75% w/w) with POo were prepared and changes in fatty acid (FA) and triacylglycerol (TAG) compositions, iodine value (IV), cloud point and thermal behaviour were studied. Reductions in palmitic (C16:0) and oleic (C18:1) acids with concomitant increases in linoleic (C18:2) and behenic (C22:0) acids were observed as the amount of WBSO increased in the blends. Blending WBSO and POo at 75:25 increased the unsaturated FA content from 56% in palm olein to 64% in the blend, producing the highest IV of 70.5 g I2/100g. At higher WBSO ratios, triunsaturated and diunsaturated TAG species within the blends increased while disaturated TAG species decreased. The lowest cloud point (8.8 °C) was obtained in the oil blend containing 50% WBSO, while the cloud point further increased with increasing amount of WBSO in the blends. This was possibly attributed to increased trisaturated TAG with very long-chained saturated FA (C20 to C24) inherently present in WBSO within the blends. Thermal behaviour analysis by differential scanning calorimetry of the oil blends showed higher onset temperatures for crystallisation with increasing proportions of WBSO in POo, with melting thermograms correspondingly showing decreasing onset melting temperatures. These findings showed that blending WBSO with POo enhanced the physicochemical characteristics of the final oil blends, resulting in higher unsaturation levels and improved cloudiness resistance.


OCL ◽  
2022 ◽  
Vol 29 ◽  
pp. 3
Author(s):  
Mohammad Mahdi Taghvaei ◽  
Habibollah Samizadeh Lahiji ◽  
Mohammad Mohsenzadeh Golfazani

Rapeseed is the third-largest source of plant oil and one of the essential oil plants worldwide. Cold stress is one of the critical factors that affect plant yield. Therefore, improving cold stress tolerance is necessary for yield increase. The present study investigated BnCAT1 and BnCSD1 genes’ expression behavior in a tolerant and sensitive cultivar under cold stress (4 °C). Besides, protein-protein interaction networks of CATs and CSDs enzymes, and their association with other antioxidant enzymes were analyzed. Moreover, the microRNAs targeting BnCAT1 and BnCSD1 genes were predicted. This study indicated many direct and indirect interactions and the association between the components of the plant antioxidant system. However, not only did the CATs and CSDs enzymes have a relationship with each other, but they also interacted directly with ascorbate peroxidase and glutathione reductase enzymes. Also, 23 and 35 effective microRNAs were predicted for BnCAT1 and BnCSD1 genes, respectively. The gene expression results indicated an elevated expression of BnCAT1 and BnCSD1 in both tolerant and sensitive cultivars. However, this increase was more noticeable in the tolerant cultivar. Thus, the BnCSD1 gene had the highest expression in the early hour of cold stress, especially in the 12th h, and the BnCAT1 gene showed the highest expression in the 48th h. This result may indicate a functional relationship between these enzymes.


OCL ◽  
2021 ◽  
Vol 28 ◽  
pp. 30
Author(s):  
Viktória Kapcsándi ◽  
Erika Hanczné Lakatos ◽  
Beatrix Sik ◽  
László Ádám Linka ◽  
Rita Székelyhidi

In this study, we examined the yield and oil quality of eight different grape varieties. For the experiments, the grape seeds were obtained from the Benedictine Pannonhalma Archabbey in the northwestern region of Hungary. The aim of the studies was to determine the oil yield obtained by extraction and to examine the differences between the fatty acid composition, antioxidant capacity, and total polyphenol content of the oils of different grape varieties. Based on the results, the oil content of the grape seeds varied between 99.91 g/kg and 126.74 g/kg. The grape seed oils analysed contained significant amounts of stearic acid (3.42–9.93%), palmitic acid (7.81–10.66%), oleic acid (14.29–19.92%), and linoleic acid (66.85–72.47%). Besides, the grape seed oils tested contained several other fatty acids in small amounts. There were significant differences in the total antioxidant and total polyphenol content of the oils. Total polyphenol content ranged from 0.24 to 1.13 mg GAE/g, while the total antioxidant content changed between 0.12 and 0.78 μg TEAC/g. The results show that the studied varieties are suitable for the production of table grape seed oil based on their oil yield, and the oils have favourable, health-protecting properties in terms of their quality.


OCL ◽  
2021 ◽  
Vol 28 ◽  
pp. 36
Author(s):  
Toluwase Hezekiah Fatoki ◽  
Cecilia O. Akintayo ◽  
Omodele Ibraheem

Olive oil possesses medicinal properties which include antimicrobial, antioxidant and anti-inflammatory, anti-diabetes, and anti-cardiovascular diseases. Oleic acid is the most abundant (95%) constituent of olive oil and others include linoleic acid, oleuropein, oleanolic acid, maslinic acid, melatonin, and others. The objective of this study is to predict the molecular targets and properties of key bioactive components of olive oil in human. Bioinformatics methods, which involved pharmacokinetics prediction, target prediction and gene network analyses, were used. The results showed that oleic acid has similar targets with linoleic acid, and showed significant probability of binding to several targets such as fatty acid-binding proteins in the adipose, epidermal, liver and muscle as well as alpha, delta and gamma peroxisome proliferator-activated receptors (PPARs). Carbonic anhydrase showed to be the only significant target of tyrosol, while protein-tyrosine phosphatase 1B, and CD81 antigen were targeted by maslinic acid and oleanolic acid. This study has applauded oleic acid, linoleic acid and tyrosol as olive oil bioactive constituents that have several potential pharmacological effects in humans that modulate several enzymes, receptors and transcription factors. The future work will be to investigate the effects of oleic acid on fatty acid-binding proteins and telomerase reverse transcriptase; melatonin on quinone reductase 2; tyrosol on carbonic anhydrase II; maslinic acid and oleanolic acid on protein-tyrosine phosphatase 1B.


OCL ◽  
2021 ◽  
Vol 28 ◽  
pp. 9
Author(s):  
Marie-Caroline Michalski ◽  
Mélanie Le Barz ◽  
Cécile Vors

The metabolic impact of dietary lipids needs to be considered beyond the fatty acid profile and energetic value of such lipids. Fatty acids are the building blocks of the different lipid molecules, including triacylglycerols and phospholipids, which are organized within various supramolecular structures such as emulsion droplets. These structures can also be naturally present or incorporated a posteriori in different food matrices. Gut health including its barrier function and microbiota is now recognized as a major player in cardiometabolic health. Even if more than 95% of dietary lipids are absorbed by the intestine to reach the bloodstream within the chylomicrons, a small proportion that is not absorbed is however able to interact with the microbiota and the cells of the distal intestine. The present non-exhaustive review will summarize briefly recent work on the impact of dietary lipids on absorption and their metabolic fate in the intestine, in particular on endotoxemia and low-grade inflammation related to obesity. Functional lipids are important ingredients used in food formulation and recent work has revealed the potential impact of some food emulsifiers on metabolism and inflammation in rodents in line with intestinal effects. Of particular interest in this review will be also recent findings on the benefits of dairy polar lipids on human lipid metabolism and their beneficial effects on metabolic inflammation in preclinical models. The review will also address the underlying mechanisms related to the metabolic fate of specific lipids such as sphingomyelin in the distal intestine, the microbiota and some actors of the intestinal barrier. Finally, these recent findings will be considered in the concept of the “food matrix effect” opening perspectives in the nutritional management of metabolic disorders.


OCL ◽  
2021 ◽  
Vol 28 ◽  
pp. 58
Author(s):  
Sergey Gontcharov ◽  
Natalya Goloschapova

Downy mildew is one of the most important diseases of sunflower crop around the world caused by Plasmopara halstedii (Farl.) Berl.et de Toni. The aim of our study was to evaluate the horizontal resistance of elite and prospective lines to downy mildew in field conditions. Experiments were conducted at All-Russia Research Institute of Oil Crops (VNIIMK) in 2016–2020. Released and prospective sunflower lines bred at VNIIMK were studied, divided into four groups on the base of their race-specific resistance in laboratory tests. Experimental design was randomized blocks with two replications. Evaluation was made by recording all the recognizable symptoms of downy mildew from emergence till flowering. The results obtained allowed us to identify the lines with the highest race non-specific resistance to downy mildew: VK 678 (5.3%), VK 653 (7.3%), VA 760 (3.3%), VA 93 (2.0%) and VK 732 (6.3%). The final aim is the development of sunflower hybrids with the most durable resistance to downy mildew, combining one parental line with the major gene (Pl15) most effective for the specific location and the second parental line with a high level of horizontal resistance to downy mildew.


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