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Published By Springer-Verlag

1573-6903, 0364-3190

Author(s):  
Dandan Yan ◽  
Na Wang ◽  
Jianling Yao ◽  
Xu Wu ◽  
Jingping Yuan ◽  
...  
Keyword(s):  

Author(s):  
Hongxia Yu ◽  
Jianhong Shi ◽  
Yiyou Lin ◽  
Yehui Zhang ◽  
Qihang Luo ◽  
...  

Author(s):  
Xiang-Xin Chen ◽  
Tao Tao ◽  
Sen Gao ◽  
Han Wang ◽  
Xiao-Ming Zhou ◽  
...  

Author(s):  
Faheem Ullah ◽  
Rashmi Gamage ◽  
Monokesh K. Sen ◽  
Erika Gyengesi

Author(s):  
Nobuyuki Takei ◽  
Daisaku Yokomaku ◽  
Takaho Yamada ◽  
Tadasato Nagano ◽  
Akiyoshi Kakita ◽  
...  
Keyword(s):  

Author(s):  
Dongyong Zhu ◽  
Bo He ◽  
Mengdi Zhang ◽  
Yixuan Wan ◽  
Ruibin Liu ◽  
...  

AbstractProlonged exposure to high altitudes above 2500 m above sea level (a.s.l.) can cause cognitive and behavioral dysfunctions. Herein, we sought to investigate the effects of chronic exposure to plateau hypoxia on the hippocampus in a rat model by using voxel-based morphometry, creatine chemical exchange saturation transfer (CrCEST) and dynamic contrast-enhanced MR imaging techniques. 58 healthy 4-week-old male rats were randomized into plateau hypoxia rats (H group) as the experimental group and plain rats (P group) as the control group. H group rats were transported from Chengdu (500 m a.s.l.), a city in a plateau located in southwestern China, to the Qinghai–Tibet Plateau (4250 m a.s.l.), Yushu, China, and then fed for 8 months there, while P group rats were fed in Chengdu (500 m a.s.l.), China. After 8 months of exposure to plateau hypoxia, open-field and elevated plus maze tests revealed that the anxiety-like behavior of the H group rats was more serious than that of the P group rats, and the Morris water maze test revealed impaired spatial memory function in the H group rats. Multimodal MR imaging analysis revealed a decreased volume of the regional gray matter, lower CrCEST contrast and higher transport coefficient Ktrans in the hippocampus compared with the P group rats. Further correlation analysis found associations of quantitative MRI parameters of the hippocampus with the behavioral performance of H group rats. In this study, we validated the viability of using noninvasive multimodal MR imaging techniques to evaluate the effects of chronic exposure to a plateau hypoxic environment on the hippocampus.


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