ВИЗНАЧЕННЯ ГІГІЄНІЧНИХ ВЛАСТИВОСТЕЙ ВКЛАДНИХ ІНДИВІДУАЛЬНИХ ЗАСОБІВ З ВСТАВКАМИ РОСЛИННОЇ СИРОВИНИ У ВЗУТТЯ

Purpose: To conduct experimental studies of embedded hygienic installed insoles with tableted plant inserts in footwearMethodology. The properties of embedded hygienic insoles have been studied for vapor permeability and moisture content according to the methods of GOST 22900-78. The solid inserts were ground and extracted with distilled water for a week to obtain aqueous extracts for microbiological studies. Determination of antimicrobial activity was performed using a culture of S.aureus ATCC 25923 in microtiter 96-well plates in liquid nutrient medium NB spectrophotometrically by optical density (Hipo MPP-96, Biosan, λ = 620 nm, control medium – by the location of a non-sterile sample with (30 × 30 mm) on the surface of sterile NA medium.Findings. To improve the hygienic characteristics of the inner space of the shoe, the research presents embedded hygienic products with solid inserts in the form of tablets from the plant raw materials of medicinal thyme and sage. The technological characteristics of tableted inserts from vegetable raw materials are given. The results of vapor permeability and moisture content in the studied samples are obtained, which correspond to the normative values according to GOST 940-81 and are safe for human feet.Originality. Determination of indicators of vapor permeability and moisture content of embedded hygienic installed insoles with tableted plant inserts and establishing their compliance with regulatory requirements. Determined the regularities of inhibitory effect of aqueous extracts of thyme on the growth of biomass of gram-negative bacteria in planktonic culture.Practical value. Another advantage of custom-made shoes is the ability to consider the customer's preferences regarding shoe care products during the operation. At the same time, an important task is to ensure the hygiene of the inner space of the shoe through the use of insoles containing elements obtained from medicinal plant materials.

ВПЛИВ РОЗМІРУ ПОР ТА МОРФОЛОГІЇ МЕЗОПОРИСТОГО КРЕМНІЮ НА ВИВІЛЬНЕННЯ МЕТОПРОЛОЛУ ТАРТРАТУ

Purpose. Study pore size effect and morphology of mesoporous silica on metoprolol tartrate release.Methodology. A sample of hollow mesoporous silicon dioxide with amino-functional groups containing 12.7 wt. % metoprolol tartrate has been investigated as potential carriers for the controlled release of active substance. Studies of the release profiles of metoprolol tartrate were performed under the following conditions: dissolution medium was buffer solution with a pH of 7.4 (phosphate buffer); sampling time: from 0.5 h before 18 h. The metoprolol concentration in the liquid phase was evaluated by a UV-Vis spectrophotometer (Persee TU-190, Beijing, China) by use of quartz cuvettes with an optical path length of 1 cm at a maximum wavelength of 274 nm.Findings. In this work we have studied mesoporous silica as possible carrier to controlled release of metoprolol tartrate, a drug used in the treatment of some diseases of the cardiovascular system. The material for research was a sample of hollow mesoporous silicon dioxide with amino-functional groups 200–400 nm in size and 20–30 nm in shell thickness. A calibrated curve to determine the amount of metoprolol was constructed by determining the absorption dependence of the concentration of metoprolol in the range from 10 to 300 ppm. The same drug concentration was obtained as calculated from the drug release test formula, which concludes that the release of metoprolol is controlled.Originality. The controlled release of a sample of hollow spheres of mesoporous silicon dioxide filled with metoprolol tartrate was studied, which was synthesized by the School of Chemistry and Chemical Engineering, Qilu University of Technology, using a new technology, where hollow spheres of mesoporous silicon dioxide with amino groups were synthesized using CO2 gas bubbles as templates.Practical value. The metoprolol release amount could achieve a 50% release amounts within 1 hour and 90% within 5 hours, indicating that the synthesized mesoporous hollow sphere could achieve controlled drug release, and shows the potential of carriers with stimulus response and targeted therapy.

РОЗРОБЛЕННЯ ПРОГРАМНОГО ЗАБЕЗПЕЧЕННЯ ДЛЯ ОЦІНЮВАННЯ ОДНОРІДНОСТІ РОЗПОДІЛУ НАПОВНЮВАЧА В ПОЛІМЕРНІЙ МАТРИЦІ

Purpose. Creation of software for evaluating the uniformity of distribution of the filler in a polyethylene matrix.Methodology. Software development was carried out using the Python programming language and libraries: PIL, Numpy, Matplotlib, Xlsxwriter. The suitability of the developed software for use was determined by verifying it. During this verification, polyethylene compositions filled with colloidal graphite in the form of compressed films were evaluated. To obtain these compositions, we chose P6006AD grade polyethylene and C-1 colloidal graphite. Samples of polyethylene compositions were obtained in two stages: 1) obtaining a strand by extrusion; 2) additional mixing of the composition on a disc mixer and pressing the obtained compositions into a film.Findings. The software has been developed to assess the uniformity of the distribution of the filler in the polyethylene matrix. The data were established on the dependence of the coefficient of heterogeneity of polyethylene compositions on the content of colloidal graphite with use of the developed software. The increase in the content of the filler leads to a decrease in its heterogeneity. It is shown that this effect can be explained by the structuring of the filler in the polyethylene matrix. Despite the formation of aggregates in polyethylene compositions, a significant amount of small colloidal particles of graphite is located between the aggregate space. This leads to a certain leveling of the concentration in the film and reduces its inhomogeneity.Scientific novelty. The influence of the content of colloidal graphite on the homogeneity of polyethylene compositions is determined. It is shown that with an increase in the graphite content from 0 to 20% vol. the coefficient of heterogeneity of the composition decreases from 5.3% to 3.9%, which is due to the structuring of the filler in the polyethylene matrix.Practical value. Software that makes it possible to evaluate the uniformity of the distribution of filler particles in a polymer matrix, and can be used to study the quality of mixing of polymer composite materials has been developed.

ОЦІНКА ЯКОСТІ ПИТНИХ ВОД З РІЗНИХ ДЖЕРЕЛ ВОДОПОСТАЧАННЯ

Purpose. Monitor different sources of water supply in a particular region of Ukraine. Methodogy. To monitor the drinking water of the selected settlement of Cherkasy region, water from the water supply network (10 samples), water from the pump room (1 sample) and water from wells (26 samples) were selected and analyzed for 20 main chemical indicators in accordance with the requirements of DSanPiN 2.2.4-171-10 and DSTU 7525: 2014. Findings. It was found that tap water has a slight excess of iron and turbidity in 5 samples. The water does not contain aluminum, ammonium ions, nitrates, nitrites, residual amounts of free and bound chlorine and chlorination by-products. The sample of water from the pump room has a slight excess of silicon and salts of general hardness – calcium and magnesium ions. Water from the pump room in chemical composition (pH, dry matter, alkalinity, chlorides, sulfates, sodium) and the content of microcomponents is very similar to tap water, it has a slightly higher "color" and "turbidity", but the content of petroleum products and iron does not exceed drinking standards. water – 0.1 mg / dm3 and 0.2 mg / dm3, respectively. In this case, well water is the most unsuitable for drinking purposes. It was found that the largest excess of normalized values in these waters was observed when determining the dry residue (up to 4 standards), hardness (up to 5 standards), nitrate concentration (up to 9 standards).Originality. Monitoring of drinking water in the selected settlement of Cherkasy region and the analysis of the suitability of tap water, pump room water and well water for drinking needs.Practical value. The peculiarities of the chemical composition of drinking water supply facilities of this settlement have been established, in particular, much attention is paid to the determination of microelements and persistent organic toxicants at the level of their maximum permissible concentrations. The analysis of the obtained results testifies that the quality of tap water and pump room meets the current hygienic standards in terms of organoleptic parameters, general mineralization, hardness, alkalinity, content of organic components, and water in almost all wells does not meet.

ДОЦІЛЬНІСТЬ ЗАСТОСУВАННЯ СТЕРИЧНО УСКЛАДНЕНИХ АЦЕНАФТЕНОВИХ СПОЛУК У СКЛАДІ ПРОТИКОРОЗІЙНОЇ КОМПОЗИЦІЇ

Goal. Synthesis and study of the effect of the inhibitory component – sterically complicated acenaphthene compounds – on the effectiveness of the protective composition to prevent corrosion of metal products during the period of temporary preservation.Method. Coke-chemical acenaphthylene was isolated from the absorbing and anthracene fractions of coal tar, the bromination of which led to 1,2-dibromocenaphthene. Subsequent alkylation of azine bases with 1,2-dibromacenaphthene yielded a number of sterically complex acenaphthene compounds. In the conditions of simulation aggressiveness of NSS environment the influence of synthesized additives on efficiency of anticorrosive composition is investigated (ISO 9227:2017). Research methods: chromatography, synthesis, elemental analysis, IR spectroscopy, corrosion tests.Results. On the basis of low-demand, available and inexpensive components of coke production, a number of substances with high anti-corrosion properties were synthesized – Quaternary azine salts with acenaphthene fragment. It was determined that the greatest resistance to the destructive effects of corrosive NSS environment according to the results of accelerated atmospheric corrosion tests was demonstrated by a composite coating containing an inhibitory additive – 1-(2-bromo-1,2-dihydroacenaphthylen-1-yl) quinoline bromide. The dominant role of the structure of the inhibitory additive on the manifestation of anticorrosive properties of the protective composition is shown. The influence of the ratio of components of paints and varnishes on their technological and anti-corrosion properties has been studied. The obtained results allow to create a new formulation of the domestic competitive protective composition to prevent corrosion of the metal for the period of temporary preservation.Scientific novelty. The role of 1,2-dibromacenaphthene as a promising alkylating agent in the synthesis of inhibitory additives - sterically complicated acenaphthene compounds has been determined.Practical significance. The optimal content of inhibitory components – Quaternary azine salts with acenaphthene fragment – for the development of a formulation of an effective anti-corrosion composition for the period of temporary preservation of metal products.

ОЦІНЮВАННЯ ГЕОМЕТРИЧНИХ ПАРАМЕТРІВ ПОЛЮСНОЇ СИСТЕМИ МАТРИЦІ ЕЛЕКТРОМАГНІТНОГО СЕПАРАТОРА

Purpose. The choice of the geometric dimensions ratios of system of matrix poles of electromagnetic polygradient separator to increase productivity with maintaining the reliability of extracting of ferromagnetic impurities from bulk material.Methodology. To solve the dynamic problem of motion of a ferromagnetic body in the working gap of pole system of matrix of polygradient separator under the influence of an external magnetic field the known methods of solving linear inhomogeneous differential equations are used. To confirm the reliability of obtained results the method of experimental research is used.Findings. The formulation of dynamic problem of movement of ferromagnetic body in the working gap of plate pole system of matrix of polygradient separator is carried out. Parametric equation for the trajectory of ferromagnetic body removal and a calculated relation connecting the main geometric dimensions of the system of matrix poles are obtained. The calculation results are confirmed experimentally and by operating practice of known magnetic separating devices.Originality. The mathematical description of working process of a polygradient electromagnetic separator with a plate matrix was further developed, which made it possible to obtain an analytical expression that takes into account the main geometric dimensions of the working space of matrix of separator.Practical value. Accounting of obtained analytical dependences between the length of separation zone and air gap, which characterizes the thickness of the separated material layer through which the ferromagnetic body must pass during the separation process, will ensure the necessary purity and productivity of separation.

РОЗРОБКА МЕДИЧНОЇ ІНФОРМАЦІЙНОЇ СИСТЕМИ ДЛЯ МЕДИЧНИХ ЗАКЛАДІВ ПЕРВИННОЇ ЛАНКИ

Purpose. Development of a web application with a functional module for conducting prescriptions according to the ICPC2 standard for primary care facilities.Methodology. The C # 8.0 language and the ASP.Net Core 5.0 framework were chosen to implement a server application with the RESTful architecture. The MySql database is selected as the database. HTML5 SASS, JavaScript, React and Redux were used to develop the client part.Findings. Theoretical bases and business processes of medical information systems are investigated. The basic principles of building a modern information system are studied. A medical information system with a high rate of reliability and speed has been designed and implemented. Developed a web application with a client-server architectureOriginality. Features of modern applied medical information systems are revealed. Possibilities of medical information as the main means of medical data storage are considered. The process of conducting medical reception according to the ICPC2 standard for primary care facilities has been worked out. Theoretical bases of construction of software information system for polyclinic and outpatient clinic are investigated.Practical value. A medical information system with a high level of reliability and speed, an interface understandable for all age groups of users has been designed and implemented. Developed a web application with client-server architecture.

ПОРІВНЯННЯ ПОЛІОЛІВ ЯК КАРБОНІЗУЮЧИХ АГЕНТІВ ВОГНЕЗАХИСНИХ КОМПОЗИЦІЙ ІНТУМЕСЦЕНТНОГО ТИПУ

Purpose. To study the influence of the carbonizing agent structure on the formation of thermal insulating char layer of intumescent system acid donor/polyol and on the fire protection efficiency of the system at high temperatures. Methodology. A fire retardant mixture of an acid donor (phosphates ammonium, urea, melamine)/ polyol was chosen as a model intumescent system. Dispersion of vinyl acetate copolymer with ethylene was used as a polymeric component. The study applied the characteristics of the char layer of the intumescent composition at a certain temperature. The volumetric intumescent coefficient (K, cm3/g), mass of char residue (m, %), structure and density of the char layer are proposed as the main estimated parameters of flame retardant effect. IR spectroscopy was used to identify products of thermolysis of intumescent systems. Determination of fire protection efficiency of intumescent coatings was carried out in a mini-oven under standard fire conditions. Findings. The influence of polyol structure on the formation of thermal insulating char layer of intumescent acid donor/polyol system and the prediction of fire protection efficiency of this system under high temperature conditions has been investigated. It has been shown that under conditions of thermal shock the fire protection efficiency is more dependent on the nucleophilic reactivity of the polyol towards the unsaturated phosphorus atom of the acid donor than on its thermal stability. It has been found that pentaerythritol, dipentaerythritol, starch, dextrin, xylitol and sorbitol are the most effective carbonizing agents, regardless of the structure of the acid donor. It has been proved by infrared spectroscopy that at high temperatures as a result of the decomposition of pentaerythritol one of the reaction products is the aldehydes interacting with pentaerythritol with the formation of oligomeric compounds with a simple ether bond C-O-C. At the same time, pentaerythritol can be considered as a universal source of carbon framework for intumescent flame retardants regardless of the phosphate structure used. Originality. It has been shown that an important factor to increase the fire protection efficiency of intumescent systems is the use of polyols with an increased nucleophilicity in the esterification between polyol and phosphoric acid.Practical value. The optimal polyols as carbonizing agents for formulation of intumescent coatings with enhanced fire protection properties have been determined.

ВИЗНАЧЕННЯ ПАРАМЕТРІВ ФОТОЕЛЕКТРИЧНОЇ СИСТЕМИ З АКУМУЛЯТОРОМ ДЛЯ ПОТРЕБ ЛОКАЛЬНОГО ОБ’ЄКТУ

Purpose. Improving the methodology for determining the parameters of a photoelectric system with a battery for the needs of a local object using archival data of the generation of a photoelectric battery with planning the cost of energy consumption from the network for all seasons of the year.Methodology. Using an archive of data on the power generation of a photoelectric battery and analysis of energy processes in a photoelectric system with a battery using computer simulation.Findings. Calculated according to the archive data for five years, the average monthly values of photoelectric battery generation power for time intervals during the day determined according to tariff zones. Dependencies to determine the recommended average value load power of a local object at time intervals.Originality. It is proposed to determine the base schedule of the local facility and the parameters of the photoelectric system based on the average monthly values of photoelectric battery generation in the transition seasons – October, March and the expected cost of energy consumed from the grid during the year. The recalculation of the base value of power during the year is substantiated taking into account the duration of daylight. A method for determining the recommended load schedule of a local object with the formation of the battery charge according to the average monthly value of the photoelectric battery generation power at time intervals during the day, which are determined by archival data for the object location.Practical value. The obtained solutions are the basis for designing photoelectric systems with a battery to meet the needs of local objects.

РОЗРОБКА ІНФОРМАЦІЙНОЇ МОДЕЛІ МОНІТОРИНГУ ЕКОСИСТЕМИ

Goal. Development of an information model for monitoring ecosystem data obtained from facilities to identify deviations from the standard, in real time, at a distance and make decisions to eliminate themMethodology. The development of the system was based on the Minimum viable product with minimal functionality. and the minimum cost of resources. The concept of system development is considered on the example of a reasonable dormitory, where one of the components of the system is the Internet of Things technology, in which different device connect to the Internet and interact with each other. The sensors allow the device to send data to a computer program that will collect and analyze it. This will allow you to effectively identify the problem in the event of deviations from the standard during the operation of s and will facilitate the prediction of possible accidents, malfunctions and their elimination.Results. Based on the analysis of the characteristics of microcontrollers and sensors, a wireless communication module installed in the device of the monitoring system was selected, and types of sensors were selected for collecting and further analysis of ecosystem indicators The structural elements of the subsystem and the code for the example of the board for the sensor have been developed. To implement the task, the open programming language Processing and development tools were chosen that would satisfy all the requirements and have the necessary functionality. TelegramBot was chosen as the interface for the ecosystem's automated storage database concepts. To connect hardware devices, APIs and Internet services, Node-RED was chosen as the programming tool. To write the bot, the RedBot package for NodeRED was used.Scientific novelty. An original solution is proposed for the development of an information model of ecosystem indicators in premises based on the element base of the selected monitoring module, communication protocols and an interface for interacting with the user through a chat bot.Practical significance. The system was tested on data obtained in the hostel KNUTD in may 2021. This environment is hosted on Amazon Web Services (AWS) EC2The test results showed the system's operability, the ability to receive and analyze information in real time and quickly respond to dangerous situations. All this will improve the life of students in the hostel and ensure themselves and their health from the influence of negative factors.