This chapter details some basic economics on how a sellers’ cartel sets its prices and volumes, and the losses these generate. In any damage action, the claimant must quantify the prices and volumes in the absence of the cartel. These are referred to as the ‘counterfactual’, ‘but for’, or to use the term in the Damages Directive, the ‘non-infringement’ prices and volumes. Overcharge, volume, and efficiency losses depend on demand and supply conditions, market structure, cost structure, and barriers to entry. The size of the overcharge and volume effect depends on the assumed counterfactual or non-infringement benchmark. If the benchmark is a competitive market, the losses will be largest. However, if the non-infringement situation are prices that would have been charged in a more concentrated market, then the overcharge and volume effects will be smaller.