ChemInform Abstract: SOLID-PHASE SYNTHESIS AND SOME PHARMACOLOGICAL PROPERTIES OF 4-THREONINE ANALOGS OF VASOPRESSINS AND VASOTOCIN AND OF ARGININE-VASOPRESSIN AND ARGININE-VASOTOCIN

1973 ◽  
Vol 4 (38) ◽  
pp. no-no
Author(s):  
M. MANNING ◽  
E. J. COY ◽  
W. H. SAWYER ◽  
M. ACOSTA
Keyword(s):  
Arginine Vasopressin ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Arginine Vasotocin ◽  
Pharmacological Properties ◽  
Phase Synthesis

Synthesis of [1-β-mercaptopropionic acid, 8-D-arginine]vasopressin (DDAVP) in solid phase. Simple optimalization

1979 ◽  
Vol 44 (4) ◽  
pp. 1173-1178 ◽  
Author(s):  
Viktor Krchňák ◽  
Milan Zaoral
Keyword(s):  
Arginine Vasopressin ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Experimental Conditions ◽  
Phase Synthesis ◽  
Mercaptopropionic Acid ◽  
Better Than

A series of solid-phase syntheses of the protected precursor II of DDAVP was carried out. Experimental conditions were developed under which practically pure II can reproducibly be obtained in yields better than 60%. The protected precursors of DDAVP obtained by liquid- and solid-phase synthesis and DDAVP samples obtained from these precursors were undistinguishable by conventional analytical or pharmacological assays.

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