ChemInform Abstract: Enantioselective Synthesis of β-Blockers via Hydrolytic Kinetic Resolution of Terminal Oxiranes by Using Bimetallic Chiral {{2,2′-[Cyclohexane-1,2-diylbis(nitrilomethylidyne)]bis [phenolato]}(2-)}cobalt ([Co(salen)])-Type Complexes.

ChemInform ◽  
2008 ◽  
Vol 39 (25) ◽  
Author(s):  
Rahul B. Kawthekar ◽  
Geon-Joong Kim
Keyword(s):  
Kinetic Resolution ◽  
Enantioselective Synthesis ◽  
Hydrolytic Kinetic Resolution ◽  
Β Blockers

A new and efficient enantioselective synthesis of both enantiomers of the calcium channel blocker bepridil

2017 ◽  
Vol 41 (2) ◽  
pp. 824-829 ◽  
Author(s):  
Mohammad Mujahid ◽  
Jambu Subramanian ◽  
Viswanadh Nalla ◽  
Murugesan Sasikumar ◽  
Sunita Sharad Kunte ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Kinetic Resolution ◽  
Channel Blocker ◽  
Enantioselective Synthesis ◽  
Mitsunobu Reaction ◽  
Hydrolytic Kinetic Resolution ◽  
Key Steps

We report a simple enantioselective synthesis of bepridil enantiomers employing hydrolytic kinetic resolution and the Mitsunobu reaction as key steps.

Concise synthesis of β-blockers (S)-metoprolol and (S)-betaxolol using hydrolytic kinetic resolution

Tetrahedron ◽  
2007 ◽  
Vol 63 (8) ◽  
pp. 1872-1876 ◽  
Author(s):  
M. Muthukrishnan ◽  
Dinesh R. Garud ◽  
R.R. Joshi ◽  
R.A. Joshi
Keyword(s):  
Kinetic Resolution ◽  
Hydrolytic Kinetic Resolution ◽  
Β Blockers
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