Arylboronate Ester Protected Amino Acids as Orthogonal Building Blocks for Fmoc Solid-Phase Peptide Synthesis

2017 ◽  
Vol 2017 (39) ◽  
pp. 5916-5920 ◽  
Author(s):  
Chao Liu ◽  
Yan Zou ◽  
Hui Song ◽  
Yuan-Ye Jiang ◽  
Hong-Gang Hu
Keyword(s):  
Amino Acids ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Building Blocks

scholarly journals Caged O-phosphorothioyl amino acids as building blocks for Fmoc-based solid phase peptide synthesis

Tetrahedron ◽  
2007 ◽  
Vol 63 (27) ◽  
pp. 6185-6190 ◽  
Author(s):  
Andreas Aemissegger ◽  
Christina N. Carrigan ◽  
Barbara Imperiali
Keyword(s):  
Amino Acids ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Building Blocks

ChemInform Abstract: 4-Methoxybenzyloxycarbonyl Amino Acids in Solid Phase Peptide Synthesis.

ChemInform ◽  
1988 ◽  
Vol 19 (16) ◽  
Author(s):  
S. S. WANG ◽  
S. T. CHEN ◽  
K. T. WANG ◽  
R. B. MERRIFIELD
Keyword(s):  
Amino Acids ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis

scholarly journals Reinvestigation of a Critical Reductive Amination Step Leads to an Optimized Protocol for the Synthesis of N-2-Hydroxybenzylcysteine Peptide Crypto-Thioesters

2020 ◽  
Author(s):  
Skander Abboud ◽  
Vincent AUCAGNE
Keyword(s):  
Peptide Synthesis ◽  
Reaction Mechanisms ◽  
Reductive Amination ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Building Blocks ◽  
Native Chemical Ligation ◽  
Chemical Ligation ◽  
Optimized Protocol ◽  
Depth Study

An in-depth study of the Fmoc-based solid phase peptide synthesis of N-Hnb-Cys crypto-thioester peptides, advantageous building blocks for the native chemical ligation-based synthesis of proteins, led to the identification of epimerized and imidazolidinone side products formed during a key reductive amination step. The understanding of the underlying reaction mechanisms was crucial for the developement of an automatable optimized synthetic protocol.

On the use of s-t-butylsulphenyl group for protection of cysteine in solid-phase peptide synthesis using fmoc-amino acids

Tetrahedron ◽  
1987 ◽  
Vol 43 (12) ◽  
pp. 2675-2680 ◽  
Author(s):  
Ramon Eritja ◽  
J.Paige Ziehler-Martin ◽  
Peter A. Walker ◽  
Terry D. Lee ◽  
Kassu Legesse ◽  
...  
Keyword(s):  
Amino Acids ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis

Solid-phase peptide synthesis using Nα-trityl-amino acids

2001 ◽  
Vol 8 (6) ◽  
pp. 331-338
Author(s):  
Beatriz G. de la Torre ◽  
Miguel A. Marcos ◽  
Ramon Eritja ◽  
Fernando albericio
Keyword(s):  
Amino Acids ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis

scholarly journals Development of oxetane modified building blocks for peptide synthesis

2020 ◽  
Vol 18 (28) ◽  
pp. 5400-5405 ◽  
Author(s):  
Stefan Roesner ◽  
Jonathan D. Beadle ◽  
Leo K. B. Tam ◽  
Ina Wilkening ◽  
Guy J. Clarkson ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Building Blocks

The synthesis and use of oxetane modified dipeptide building blocks in solution and solid-phase peptide synthesis (SPPS) is reported.

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