Effects of Conversion From Calcineurin Inhibitors to Sirolimus or Everolimus on Renal Function and Possible Mechanisms in Liver Transplant Recipients

2018 ◽  
Vol 59 (3) ◽  
pp. 326-334 ◽  
Author(s):  
Kai-Fan Tsai ◽  
Lung-Chih Li ◽  
Chien-Ning Hsu ◽  
Chih-Che Lin ◽  
Yu-Hung Lin ◽  
...  
Keyword(s):  
Renal Function ◽  
Liver Transplant ◽  
Calcineurin Inhibitors ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

scholarly journals The effect of early everolimus administration on the renal function while reducing the dosage of calcineurin inhibitors in liver transplant recipients in a long-term follow-up

2021 ◽  
Vol 13 (2) ◽  
pp. 121-129
Author(s):  
V. E. Syutkin ◽  
A. A. Salienko ◽  
O. D. Olisov ◽  
S. V. Zhuravel ◽  
M. S. Novruzbekov
Keyword(s):  
Liver Transplantation ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Liver Transplant ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Calcineurin Inhibitors ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

Introduction. The lifelong use of calcineurin inhibitors in liver transplant recipients leads to an increased incidence of chronic kidney disease.Objective. To compare the changes in glomerular filtration rate over five years in liver transplant recipients between those on everolimus with a reduced exposure to calcineurin inhibitors and those on standard doses of calcineurin inhibitors.Material and methods. Fourteen liver transplant recipient switched to everolimus with a minimization of calcineurin inhibitors exposure in the first months after liver transplantation from February 2009 to February 2015 who had received that therapy continuously for at least 60 months were included in the case-control study. Twenty eight liver transplant recipients (matched by sex, etiology of the underlying disease, calcineurin inhibitors) who were followed-up for at least 60 months after liver transplantation, who had received no dose of everolimus, in whom the glomerular filtration rate could be calculated at all points of analysis were selected as a comparison group (1:2). Glomerular filtration rate was calculated immediately before liver transplantation; 12, 24, 36, 48, and 60 months after liver transplantation. The glomerular filtration rate after liver transplantation was also calculated for liver transplant recipients from the main group immediately before the conversion to everolimus.Results. Before liver transplantation, the median of glomerular filtration rate in the main group of liver transplant recipients was lower (81.2 ml/min) than in the comparison group (97.5 ml/min, p=0.01). After liver transplantation, the renal function worsened in both groups of patients. In a pairwise comparison, the medians of glomerular filtration rate were statistically significantly lower after 12 months, 24 months, 36 months, 48 months after liver transplantation, than before liver transplantation. The median of glomerular filtration rate at the time of immunosuppression conversion was 44.3 ml/min. After the conversion of immunosuppression, the median of glomerular filtration rate gradually increased, and after 36 months the differences in glomerular filtration rate reached statistical significance compared with the level before conversion (69.4 ml/min;p=0.048). These differences still increased after 60 months after conversion (72.3 ml/min; p=0.041).Conclusion. Long-term administration of everolimus with minimization of calcineurin inhibitors exposure with the early conversion to this immunosuppression regime provides a steady improvement in renal function in liver transplant recipients with a low glomerular filtration rate in the preoperative and early post-transplant period.

Long-term renal function in liver transplant recipients and impact of immunosuppressive regimens (calcineurin inhibitors alone or in combination with mycophenolate mofetil): The TRY study

2009 ◽  
Vol 15 (9) ◽  
pp. 1083-1091 ◽  
Author(s):  
Svetlana Karie-Guigues ◽  
Nicolas Janus ◽  
Faouzi Saliba ◽  
Jerome Dumortier ◽  
Christophe Duvoux ◽  
...  
Keyword(s):  
Renal Function ◽  
Mycophenolate Mofetil ◽  
Liver Transplant ◽  
Calcineurin Inhibitors ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

scholarly journals Long-Term Renal Function in Liver Transplant Recipients After Conversion From Calcineurin Inhibitors to mTOR Inhibitors

2015 ◽  
Vol 20 ◽  
pp. 707-713 ◽  
Author(s):  
Anna Hüsing ◽  
Martina Schmidt ◽  
Susanne Beckebaum ◽  
Vito R. Cicinnati ◽  
Raphael Koch ◽  
...  
Keyword(s):  
Renal Function ◽  
Liver Transplant ◽  
Calcineurin Inhibitors ◽  
Mtor Inhibitors ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

Rapamycin for treatment of renal insufficiency related to calcineurin inhibitors in liver transplant recipients

2001 ◽  
Vol 120 (5) ◽  
pp. A92-A92
Author(s):  
A HABIB ◽  
B BACON ◽  
A BEFELER ◽  
S RAMRAKHIANI ◽  
S RAMRAKHIANI
Keyword(s):  
Renal Insufficiency ◽  
Liver Transplant ◽  
Calcineurin Inhibitors ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

Non-HLA Autoantibodies at 1 Year Negatively Affect 5-Year Native Renal Function in Liver Transplant Recipients

2021 ◽  
Vol 53 (3) ◽  
pp. 1019-1024
Author(s):  
Jacqueline G. O’Leary ◽  
Aurélie Philippe ◽  
Robert Freeman ◽  
Harald Heidecke ◽  
Linda W. Jennings ◽  
...  
Keyword(s):  
Renal Function ◽  
Liver Transplant ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

scholarly journals Effect of Early Everolimus-Facilitated Reduction of Tacrolimus on Efficacy and Renal Function in De Novo Liver Transplant Recipients

2017 ◽  
Vol 101 (2) ◽  
pp. 341-349 ◽  
Author(s):  
William C. Chapman ◽  
Robert S. Brown ◽  
Kenneth D. Chavin ◽  
Debra Sudan ◽  
Baburao Koneru ◽  
...  
Keyword(s):  
Renal Function ◽  
Liver Transplant ◽  
De Novo ◽  
Transplant Recipients ◽  
Liver Transplant Recipients
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