Renal excretion of emtricitabine I: Effects of organic anion, organic cation, and nucleoside transport inhibitors on emtricitabine excretion

2008 ◽  
Vol 97 (12) ◽  
pp. 5401-5410 ◽  
Author(s):  
Tomoko Nakatani‐Freshwater ◽  
David R. Taft
Keyword(s):  
Organic Cation ◽  
Renal Excretion ◽  
Organic Anion ◽  
Nucleoside Transport ◽  
Nucleoside Transport Inhibitors ◽  
Transport Inhibitors

Organ culture as a model for investigating the effects of antimetabolites and nucleoside transport inhibitors on rodent colonic mucosa

1991 ◽  
Vol 27 (11) ◽  
pp. 873-877
Author(s):  
M. Moorghen ◽  
P. Ince ◽  
Karen J. Finney ◽  
A. J. Watson ◽  
A. L. Harris
Keyword(s):  
Organ Culture ◽  
Colonic Mucosa ◽  
Nucleoside Transport ◽  
Nucleoside Transport Inhibitors ◽  
Transport Inhibitors

Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011

2002 ◽  
Vol 13 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Christopher R Boyer ◽  
Patricia L Karjian ◽  
Geoffrey M Wahl ◽  
Mark Pegram ◽  
Saskia TC Neuteboom
Keyword(s):  
Antitumor Activity ◽  
Nucleoside Transport ◽  
Nucleoside Transport Inhibitors ◽  
Transport Inhibitors

scholarly journals Effects of Organic Anion, Organic Cation, and Dipeptide Transport Inhibitors on Cefdinir in the Isolated Perfused Rat Kidney

2003 ◽  
Vol 47 (2) ◽  
pp. 689-696 ◽  
Author(s):  
Christopher S. Lepsy ◽  
Robert J. Guttendorf ◽  
Alan R. Kugler ◽  
David E. Smith
Keyword(s):  
Organic Cation ◽  
Rat Kidney ◽  
Organic Anion ◽  
Renal Elimination ◽  
Renal Transport ◽  
Transport Mechanisms ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney ◽  
Transport Inhibitors ◽  
Dipeptide Transport

ABSTRACT Cefdinir (Omnicef; Abbott Laboratories) is a cephalosporin antibiotic primarily eliminated by the kidney. Nonlinear renal elimination of cefdinir has been previously reported. Cefdinir renal transport mechanisms were studied in the erythrocyte-free isolated perfused rat kidney. Studies were performed with drug-free perfusate and perfusate containing cefdinir alone to establish the baseline physiology and investigate cefdinir renal elimination characteristics. To investigate cefdinir renal transport mechanisms, inhibition studies were conducted by coperfusing cefdinir with inhibitors of the renal organic anion (probenecid), organic cation (tetraethylammonium), or dipeptide (glycylsarcosine) transport system. Cefdinir concentrations in biological samples were determined using reversed-phase high-performance liquid chromatography. Differences between treatments and controls were evaluated using analysis of variance and Dunnett's test. The excretion ratio (ER; the renal clearance corrected for the fraction unbound and glomerular filtration rate) for cefdinir was 5.94, a value indicating net renal tubular secretion. Anionic, cationic, and dipeptide transport inhibitors all significantly affected the cefdinir ER. With probenecid, the ER was reduced to 0.59, clearly demonstrating a significant reabsorptive component to cefdinir renal disposition. This finding was confirmed by glycylsarcosine studies, in which the ER was elevated to 7.95, indicating that reabsorption was mediated, at least in part, by the dipeptide transporter system. The effects of the organic cation tetraethylammonium, in which the ER was elevated to 7.53, were likely secondary in nature. The anionic secretory pathway was found to be the predominant mechanism for cefdinir renal excretion.

Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters

2014 ◽  
Vol 443 (2) ◽  
pp. 505-510 ◽  
Author(s):  
Masahiro Kaneko ◽  
Fumihiko Hakuno ◽  
Hiroyasu Kamei ◽  
Daisuke Yamanaka ◽  
Kazuhiro Chida ◽  
...  
Keyword(s):  
Steroid Hormones ◽  
Nucleoside Transport ◽  
Nucleoside Transport Inhibitors ◽  
Transport Inhibitors

Comparative Pharmacology of Nucleoside Transport Inhibitors

1991 ◽  
Vol 10 (5) ◽  
pp. 975-982 ◽  
Author(s):  
H. Van Belle ◽  
P. A. J. Janssen
Keyword(s):  
Nucleoside Transport ◽  
Nucleoside Transport Inhibitors ◽  
Transport Inhibitors

Novel Nucleoside Transport Inhibitors of Natural Origin

1995 ◽  
pp. 779-782 ◽  
Author(s):  
Yong-Su Zhen ◽  
Jian Su ◽  
Yu-Chuan Xue ◽  
Chang-Qing Qi ◽  
Ji-Lan Hu
Keyword(s):  
Nucleoside Transport ◽  
Natural Origin ◽  
Nucleoside Transport Inhibitors ◽  
Transport Inhibitors

scholarly journals Antihyperalgesic activity of nucleoside transport inhibitors in models of inflammatory pain in guinea pigs

2012 ◽  
pp. 391 ◽  
Author(s):  
Sabine Maes ◽  
Pype ◽  
Hoffmann ◽  
Theo Meert ◽  
Maria Biermans
Keyword(s):  
Guinea Pigs ◽  
Inflammatory Pain ◽  
Nucleoside Transport ◽  
Nucleoside Transport Inhibitors ◽  
Transport Inhibitors
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