Combination antifungal therapy for Scedosporium species in cystic fibrosis

2020 ◽  
Vol 55 (8) ◽  
pp. 1993-1995
Author(s):  
Siân Bentley ◽  
Jane C. Davies ◽  
Siobhán B. Carr ◽  
Ian M. Balfour‐Lynn
Keyword(s):  
Cystic Fibrosis ◽  
Antifungal Therapy ◽  
Scedosporium Species

Fungal epidemiology in cystic fibrosis patients with a special focus on Scedosporium species complex

2019 ◽  
Vol 129 ◽  
pp. 168-175 ◽  
Author(s):  
Mohammad T. Hedayati ◽  
Mahin Tavakoli ◽  
Maedeh Maleki ◽  
Somaye Heidari ◽  
Vida Mortezaee ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Species Complex ◽  
Special Focus ◽  
Scedosporium Species

Characteristics of pathogenic fungi and antifungal therapy in cystic fibrosis

2010 ◽  
Vol 8 (8) ◽  
pp. 957-964 ◽  
Author(s):  
Frank-Michael C Müller ◽  
Marc Seidler
Keyword(s):  
Cystic Fibrosis ◽  
Antifungal Therapy ◽  
Pathogenic Fungi

scholarly journals Use of Nebulized Amphotericin B in the Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
M. Proesmans ◽  
F. Vermeulen ◽  
M. Vreys ◽  
K. De Boeck
Keyword(s):  
Cystic Fibrosis ◽  
Amphotericin B ◽  
Antifungal Therapy ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Lung Infection ◽  
Steroid Withdrawal ◽  
Successful Therapy ◽  
Lipid Complex ◽  
Safety And Efficacy ◽  
Systemic Corticosteroids

Background. Systemic steroids and adjunctive antifungal therapy are the cornerstone in treating allergic bronchopulmonary aspergillosis (ABPA) in the context of CF.Aim. Evaluate the use of inhaled amphotericin B (iAMB) as antifungal agent in this context.Methods. Report of 7 CF patients with recurrent or difficult to treat ABPA and failure to taper systemic corticosteroids treated with AMB deoxycholate (AMB-d) (Fungizone 25 mg 3× a week) or AMB lipid complex (ABLC) (Abelcet 50 mg twice weekly). Successful therapy was defined as steroid withdrawal without ABPA relapse within 12 months.Results. Therapy was successful in 6 of 7 patients treated with iAMB. In 5/6, lung function improved. The patient with treatment failure has concomitant MAC lung infection.Conclusion. Inhaled AMB may be an alternative to commonly used adjunctive antifungal therapy in the treatment of ABPA. More data are needed on safety and efficacy.

scholarly journals Reverse line blot hybridisation screening of Pseudallescheria/Scedosporium species in patients with cystic fibrosis

Mycoses ◽  
2011 ◽  
Vol 54 ◽  
pp. 5-11 ◽  
Author(s):  
Q. Lu ◽  
A. H. G. Gerrits van den Ende ◽  
G. S. de Hoog ◽  
R. Li ◽  
I. Accoceberry ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Reverse Line Blot ◽  
Blot Hybridisation ◽  
Scedosporium Species

scholarly journals Abundance of Pseudallescheria/Scedosporium species in the Australian urban environment suggests a possible source for scedosporiosis including the colonization of airways in cystic fibrosis

2010 ◽  
Vol 48 (O1) ◽  
pp. S70-S76 ◽  
Author(s):  
Azian Harun ◽  
Felix Gilgado ◽  
Sharon C-A. Chen ◽  
Wieland Meyer
Keyword(s):  
Cystic Fibrosis ◽  
Urban Environment ◽  
Scedosporium Species

scholarly journals P162 Evaluation of the selective culture medium Scedo-Select III for Scedosporium species isolation from sputa from patients with cystic fibrosis

2019 ◽  
Vol 18 ◽  
pp. S103-S104
Author(s):  
S. Le Gal ◽  
J. Chauvet ◽  
S. Ramel ◽  
A. Dirou ◽  
A. Marot ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Culture Medium ◽  
Species Isolation ◽  
Selective Culture Medium ◽  
Scedosporium Species

scholarly journals Prevalence of Scedosporium species and Lomentospora prolificans in patients with cystic fibrosis in a multicenter trial by use of a selective medium

2015 ◽  
Vol 14 (2) ◽  
pp. 237-241 ◽  
Author(s):  
L. Sedlacek ◽  
B. Graf ◽  
C. Schwarz ◽  
F. Albert ◽  
S. Peter ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Multicenter Trial ◽  
Selective Medium ◽  
Scedosporium Species

scholarly journals In vitro susceptibilities to amphotericin B, itraconazole, and miconazole of filamentous fungi isolated from patients with cystic fibrosis.

1997 ◽  
Vol 41 (9) ◽  
pp. 2064-2066 ◽  
Author(s):  
C Hennequin ◽  
N Benailly ◽  
C Silly ◽  
M Sorin ◽  
P Scheinmann ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Amphotericin B ◽  
Filamentous Fungi ◽  
Antimicrobial Activities ◽  
Aspergillus Species ◽  
Microdilution Method ◽  
Scedosporium Species

The antimicrobial activities of amphotericin B, itraconazole, and miconazole against 101 filamentous fungi from patients with cystic fibrosis were tested by a reproducible microdilution method. Itraconazole was very active against Aspergillus species and Scedosporium species (MIC at which 90% of the isolates were inhibited [MIC90], 0.06 to 0.5 mg/liter), whereas amphotericin B was less effective (MIC90, 0.5 to 8 mg/liter).

scholarly journals Direct detection of Exophiala and Scedosporium species in sputa of patients with cystic fibrosis

2017 ◽  
Vol 56 (6) ◽  
pp. 695-702 ◽  
Author(s):  
Min Chen ◽  
Nahid Kondori ◽  
Shuwen Deng ◽  
A H G Gerrits van den Ende ◽  
M Lackner ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Direct Detection ◽  
Scedosporium Species

scholarly journals Combined antifungal therapy is superior to monotherapy in pulmonary scedosporiosis in cystic fibrosis

2019 ◽  
Vol 18 (2) ◽  
pp. 227-232 ◽  
Author(s):  
Carsten Schwarz ◽  
Claudia Brandt ◽  
Volker Melichar ◽  
Christoph Runge ◽  
Eberhard Heuer ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Antifungal Therapy
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