Structure-Activity Relationships in a Peptidic α7 Nicotinic Acetylcholine Receptor Antagonist

Nicotinic Acetylcholine ◽

Structure–activity relationships of N-substituted ligands for the α7 nicotinic acetylcholine receptor

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.11.023 ◽

2010 ◽

Vol 20 (1) ◽

pp. 104-107 ◽

Cited By ~ 4

Author(s):

Kathleen H. Mortell ◽

Michael R. Schrimpf ◽

William H. Bunnelle ◽

David J. Anderson ◽

Jens Halvard Gronlien ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Discovery, Synthesis, and Structure Activity of a Highly Selective α7 Nicotinic Acetylcholine Receptor Antagonist†

Biochemistry ◽

10.1021/bi7004202 ◽

2007 ◽

Vol 46 (22) ◽

pp. 6628-6638 ◽

Cited By ~ 65

Author(s):

Paul Whiteaker ◽

Sean Christensen ◽

Doju Yoshikami ◽

Cheryl Dowell ◽

Maren Watkins ◽

...

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure–Activity Relationship and Preclinical Characterization

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b01569 ◽

2019 ◽

Vol 63 (3) ◽

pp. 944-960 ◽

Cited By ~ 4

Author(s):

Neelima Sinha ◽

Navnath P. Karche ◽

Mahip Kalyan Verma ◽

Sameer S. Walunj ◽

Prashant B. Nigade ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Nicotinic Acetylcholine ◽

Structure-activity relationships of acetylcholine derivatives withLucilia cuprinanicotinic acetylcholine receptor α1 and α2 subunits in chicken β2 subunit hybrid receptors in comparison with chicken nicotinic acetylcholine receptor α4/β2

Insect Molecular Biology ◽

10.1111/imb.12014 ◽

2013 ◽

Vol 22 (2) ◽

pp. 183-198 ◽

Cited By ~ 10

Author(s):

H. Dederer ◽

M. Berger ◽

T. Meyer ◽

M. Werr ◽

T. Ilg

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2006.09.019 ◽

2006 ◽

Vol 14 (24) ◽

pp. 8219-8248 ◽

Cited By ~ 63

Author(s):

Daniel P. Walker ◽

Donn G. Wishka ◽

David W. Piotrowski ◽

Shaojuan Jia ◽

Steven C. Reitz ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Nicotinic Acetylcholine ◽

Design Synthesis ◽

Receptor Agonists ◽

Quantitative structure-activity relationships of nicotine analogues as neuronal nicotinic acetylcholine receptor ligands

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(96)00233-7 ◽

1996 ◽

Vol 4 (12) ◽

pp. 2211-2217 ◽

Cited By ~ 13

Author(s):

Ki Hwan Kim ◽

Nan-Horng Lin ◽

David J. Anderson

Keyword(s):

Acetylcholine Receptor ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Quantitative Structure ◽

Receptor Ligands ◽

Nicotinic Acetylcholine ◽

Quantitative Structure Activity Relationships

Structure Activity ◽

Discovery ofN-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship

Journal of Medicinal Chemistry ◽

10.1021/jm0602413 ◽

2006 ◽

Vol 49 (14) ◽

pp. 4425-4436 ◽

Cited By ~ 141

Author(s):

Donn G. Wishka ◽

Daniel P. Walker ◽

Karen M. Yates ◽

Steven C. Reitz ◽

Shaojuan Jia ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Cognitive Deficits ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Potential Treatment ◽

Nicotinic Acetylcholine ◽

The endogenous α7 nicotinic acetylcholine receptor antagonist kynurenic acid modulates amyloid-β-induced inflammation in BV-2 microglial cells

Journal of the Neurological Sciences ◽

10.1016/j.jns.2014.06.032 ◽

2014 ◽

Vol 344 (1-2) ◽

pp. 94-99 ◽

Cited By ~ 11

Author(s):

Levke Steiner ◽

Maike Gold ◽

David Mengel ◽

Richard Dodel ◽

Jan-Philipp Bach

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Kynurenic Acid ◽

Amyloid Β ◽

Microglial Cells ◽

Nicotinic Acetylcholine

Old and New Pharmacology: Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor by the 5-Hydroxytryptamine2B/C Receptor Antagonist SB-206553 (3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b′]di pyrrole-1(2H)-carboxamide)

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.108.146514 ◽

2008 ◽

Vol 328 (3) ◽

pp. 766-776 ◽

Cited By ~ 55

Author(s):

John Dunlop ◽

Tim Lock ◽

Brian Jow ◽

Fabrizio Sitzia ◽

Steven Grauer ◽

...

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Allosteric Modulation ◽

Nicotinic Acetylcholine

Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(98)00019-5 ◽

1998 ◽

Vol 8 (3) ◽

pp. 249-254 ◽

Cited By ~ 36

Author(s):

Nan-Horng Lin ◽

David E Gunn ◽

Yihong Li ◽

Yun He ◽

Hao Bai ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Nicotinic Acetylcholine ◽