Biological Learning: Synaptic Plasticity, Hebb Rule and Spike TimingDependent Plasticity

2011 ◽  
pp. 111-132
Author(s):  
Paul Munro ◽  
Hannu Toivonen ◽  
Geoffrey I. Webb ◽  
Wray Buntine ◽  
Peter Orbanz ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Hebb Rule ◽  
Biological Learning

Multiplicative Synaptic Normalization and a Nonlinear Hebb Rule Underlie a Neurotrophic Model of Competitive Synaptic Plasticity

2002 ◽  
Vol 14 (6) ◽  
pp. 1311-1322 ◽  
Author(s):  
T. Elliott ◽  
N. R. Shadbolt
Keyword(s):  
Synaptic Plasticity ◽  
Activity Patterns ◽  
Competitive Dynamics ◽  
Hebb Rule

Synaptic normalization is used to enforce competitive dynamics in many models of developmental synaptic plasticity. In linear and semilinear Hebbian models, multiplicative synaptic normalization fails to segregate afferents whose activity patterns are positively correlated. To achieve this, the biologically problematic device of subtractive synaptic normalization must be used instead. Our own model of competition for neurotrophic support, which can segregate positively correlated afferents, was developed in part in an attempt to overcome these problems by removing the need for synaptic normalization altogether. However, we now show that the dynamics of our model decompose into two decoupled subspaces, with competitive dynamics being implemented in one of them through a nonlinear Hebb rule and multiplicative synaptic normalization. This normalization is “emergent” rather than imposed. We argue that these observations permit biologically plausible forms of synaptic normalization to be viewed as abstract and general descriptions of the underlying biology in certain scaleless models of synaptic plasticity.

A four day course of Lovastatin improves synaptic plasticity in patients with NF-1

2011 ◽  
Vol 42 (S 01) ◽  
Author(s):  
F Mainberger ◽  
N Jung ◽  
M Zenker ◽  
I Delvendahl ◽  
U Wahlländer-Danek ◽  
...  
Keyword(s):  
Synaptic Plasticity
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