scholarly journals Structural Coverage for Lotos

2000 ◽  
pp. 19-34 ◽  
Author(s):  
Daniel Amyot ◽  
Luigi Logrippo
Keyword(s):  
Structural Coverage

scholarly journals Structural coverage of the proteome for pharmaceutical applications

2017 ◽  
Vol 22 (12) ◽  
pp. 1792-1799 ◽  
Author(s):  
Joseph C. Somody ◽  
Stephen S. MacKinnon ◽  
Andreas Windemuth
Keyword(s):  
Pharmaceutical Applications ◽  
Structural Coverage

Satisfying DO-178C Structural Coverage Objectives

2018 ◽  
Vol 44 (1) ◽  
pp. 43-50
Author(s):  
V. P. Kozyrev ◽  
M. A. Saburov
Keyword(s):  
Structural Coverage

scholarly journals Thera-SAbDab: the Therapeutic Structural Antibody Database

2019 ◽  
Author(s):  
Matthew I. J. Raybould ◽  
Claire Marks ◽  
Alan P. Lewis ◽  
Jiye Shi ◽  
Alexander Bujotzek ◽  
...  
Keyword(s):  
Sequence Data ◽  
Data Bank ◽  
World Health Organisation ◽  
Variable Domain ◽  
World Health ◽  
Sequence Identity ◽  
Single File ◽  
Domain Sequence ◽  
Structural Coverage ◽  
New Protein

The Therapeutic Structural Antibody Database (Thera-SAbDab; http://opig.stats.ox.ac.uk/webapps/therasabdab) tracks all antibody- and nanobody-related therapeutics recognised by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab) with near-exact or exact variable domain sequence matches. Thera-SAbDab is synchronised with SAbDab to update weekly, reflecting new Protein Data Bank entries and the availability of new sequence data published by the WHO. Each therapeutic summary page lists structural coverage (with links to the appropriate SAbDab entries), alignments showing where any near-matches deviate in sequence, and accompanying metadata, such as intended target and investigated conditions. Thera-SAbDab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence - returning all therapeutics that are within a specified sequence identity over a specified region of the query. The sequences of all therapeutics listed in Thera-SAbDab (461 unique molecules, as of 5th August 2019) are downloadable as a single file with accompanying metadata.

scholarly journals Genome Pool Strategy for Structural Coverage of Protein Families

Structure ◽  
2008 ◽  
Vol 16 (11) ◽  
pp. 1659-1667 ◽  
Author(s):  
Lukasz Jaroszewski ◽  
Lukasz Slabinski ◽  
John Wooley ◽  
Ashley M. Deacon ◽  
Scott A. Lesley ◽  
...  
Keyword(s):  
Protein Families ◽  
Structural Coverage

Structural Coverage Analysis Methods

2019 ◽  
pp. 36-63
Author(s):  
Parnasi Retasbhai Patel ◽  
Chintan M. Bhatt
Keyword(s):  
Execution Time ◽  
Source Code ◽  
Second Phase ◽  
Coverage Criteria ◽  
Analysis Methods ◽  
Coverage Analysis ◽  
Structural Coverage ◽  
Test Suit

Structural coverage analysis for any code is a very common approach to measure the quality of any test suit. Structural coverage determines which structure of the software or which portion is not exercised. This chapter describes two different phases to achieve structural coverage analysis using DO-178B/C standards. Statement coverage is the very basic coverage criteria which involves execution of all the executable statements in the source code at least once. Analysis of structural coverage can be done by capturing the amount of code that is covered by the airborne software. The first phase contains the instrumentation procedure which instruments the source code at execution time, and the second phase is generating a report that specifies which portion of source code is executed and which one is not in the form of a percentage.

scholarly journals Thera-SAbDab: the Therapeutic Structural Antibody Database

2019 ◽  
Vol 48 (D1) ◽  
pp. D383-D388 ◽  
Author(s):  
Matthew I J Raybould ◽  
Claire Marks ◽  
Alan P Lewis ◽  
Jiye Shi ◽  
Alexander Bujotzek ◽  
...  
Keyword(s):  
Sequence Data ◽  
Data Bank ◽  
World Health Organisation ◽  
Variable Domain ◽  
World Health ◽  
Sequence Identity ◽  
Single File ◽  
Domain Sequence ◽  
Structural Coverage ◽  
New Protein

Abstract The Therapeutic Structural Antibody Database (Thera-SAbDab; http://opig.stats.ox.ac.uk/webapps/therasabdab) tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab) with near-exact or exact variable domain sequence matches. Thera-SAbDab is synchronized with SAbDab to update weekly, reflecting new Protein Data Bank entries and the availability of new sequence data published by the WHO. Each therapeutic summary page lists structural coverage (with links to the appropriate SAbDab entries), alignments showing where any near-matches deviate in sequence, and accompanying metadata, such as intended target and investigated conditions. Thera-SAbDab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence - returning all therapeutics that are within a specified sequence identity over a specified region of the query. The sequences of all therapeutics listed in Thera-SAbDab (461 unique molecules, as of 5 August 2019) are downloadable as a single file with accompanying metadata.

Sign in / Sign up

Export Citation Format

Share Document