Computers accelerate our ability to achieve scientific breakthroughs. As technology evolves and new research needs come to light, the role for cyberinfrastructure as “knowledge” infrastructure continues to expand. In essence, cyberinfrastructure can be thought of as the integration of supercomputers, data resources, visualization, and people that extends the impact and utility of information technology. This article discusses cyberinfrastructure, the related topics of science gateways and campus bridging, and identifies future challenges and opportunities in cyberinfrastructure.